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Zdhhc5 Gene Detail
Summary
  • Symbol
    Zdhhc5
  • Name
    zinc finger, DHHC domain containing 5
  • Synonyms
    1110032A17Rik, Zisp
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923573
    NCBI Gene: 228136
  • Alliance
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:84518314-84545524 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 2, 49.45 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    500 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923573
protein coding gene Chr2:84518264-84545524 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025906
protein coding gene Chr2:85370113-85403101 (-)
A/J MGP_AJ_G0025880
protein coding gene Chr2:82073665-82100975 (-)
AKR/J MGP_AKRJ_G0025850
protein coding gene Chr2:84183213-84212786 (-)
BALB/cJ MGP_BALBcJ_G0025877
protein coding gene Chr2:82204976-82234180 (-)
C3H/HeJ MGP_C3HHeJ_G0025636
protein coding gene Chr2:84430377-84459857 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026323
protein coding gene Chr2:88020033-88048884 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023725
protein coding gene Chr2:78898091-78927135 (-)
CAST/EiJ MGP_CASTEiJ_G0025097
protein coding gene Chr2:84952619-84986340 (-)
CBA/J MGP_CBAJ_G0025617
protein coding gene Chr2:91167015-91196794 (-)
DBA/2J MGP_DBA2J_G0025748
protein coding gene Chr2:81611181-81639678 (-)
FVB/NJ MGP_FVBNJ_G0025711
protein coding gene Chr2:80862411-80892050 (-)
LP/J MGP_LPJ_G0025836
protein coding gene Chr2:85172661-85200794 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025741
protein coding gene Chr2:93486573-93522861 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026379
protein coding gene Chr2:84412442-84440378 (-)
PWK/PhJ MGP_PWKPhJ_G0024841
protein coding gene Chr2:81449289-81479983 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024645
protein coding gene Chr2:84561388-84590866 (-)
WSB/EiJ MGP_WSBEiJ_G0025167
protein coding gene Chr2:85092181-85121859 (-)



Homology
more
  • Human Ortholog
    ZDHHC5, zinc finger DHHC-type palmitoyltransferase 5
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZDHHC5, zinc finger DHHC-type palmitoyltransferase 5
  • Synonyms
    DHHC5, ZNF375
  • Links
    NCBI Gene ID: 25921
    neXtProt AC: NX_Q9C0B5
    UniProt: Q9C0B5

  • Chr Location
    11q12.1; chr11:57667747-57701182 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 4 alleles in 4 genetic backgrounds
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a hypomorphic allele exhibit partial prenatal lethality and impaired contextual conditioning. Mice homozygous for a conditional allele activated in adipocytes exhibit impaired fatty acid uptake and impairedadaptive thermogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034075 Ensembl Gene Model | MGI Sequence Detail 27211 C57BL/6J ±  kb
    transcript ENSMUST00000035840 Ensembl | MGI Sequence Detail 4706 Not Applicable  
    polypeptide ENSMUSP00000048198 Ensembl | MGI Sequence Detail 715 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 14
      Primer pair 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2138961
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 2
      Gene Ontology 11
      Phenotypes 25
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:352419 Balasubramanian A, et al., The palmitoylation of gasdermin D directs its membrane translocation and pore formation during pyroptosis. Sci Immunol. 2024 Apr 12;9(94):eadn1452

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    12/10/2024
    MGI 6.24
    The Jackson Laboratory