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Ly6k Gene Detail
Summary
  • Symbol
    Ly6k
  • Name
    lymphocyte antigen 6 family member K
  • Synonyms
    2410015A16Rik, 3110035B01Rik, mLy-6K
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923736
    NCBI Gene: 76486
  • Member of
    Ly6 cluster
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:74668723-74671817 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 34.28 cM, cytoband E1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    122 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923736
 protein coding gene Chr15:74668723-74671835 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021939
 protein coding gene Chr15:74582916-74586641 (-)
A/J MGP_AJ_G0021898
 protein coding gene Chr15:71925337-71928449 (-)
AKR/J MGP_AKRJ_G0021880
 protein coding gene Chr15:73762163-73765275 (-)
BALB/cJ MGP_BALBcJ_G0021905
 protein coding gene Chr15:71931627-71934670 (-)
C3H/HeJ MGP_C3HHeJ_G0021678
 protein coding gene Chr15:73916272-73919384 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022345
 protein coding gene Chr15:77393278-77396390 (-)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0021197
 protein coding gene Chr15:74737343-74740411 (-)
CBA/J MGP_CBAJ_G0021644
 protein coding gene Chr15:79935978-79939090 (-)
DBA/2J MGP_DBA2J_G0021769
 protein coding gene Chr15:71518092-71521204 (-)
FVB/NJ MGP_FVBNJ_G0021751
 protein coding gene Chr15:70565971-70569083 (-)
LP/J MGP_LPJ_G0021841
 protein coding gene Chr15:74644175-74647287 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021774
 protein coding gene Chr15:85243716-85248632 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022366
 protein coding gene Chr15:74153102-74156214 (-)
PWK/PhJ MGP_PWKPhJ_G0020938
 protein coding gene Chr15:71627005-71630854 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020779
 protein coding gene Chr15:74035362-74038474 (-)
WSB/EiJ MGP_WSBEiJ_G0021249
 protein coding gene Chr15:74163341-74166456 (-)



Homology
more
  • Human Ortholog
    LY6K, lymphocyte antigen 6 family member K
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LY6K, lymphocyte antigen 6 family member K
  • Synonyms
    CT97, HSJ001348, ly-6K, URLC10
  • Links
    NCBI Gene ID: 54742
    neXtProt AC: NX_Q17RY6
    UniProt: Q17RY6

  • Chr Location
    8q24.3; chr8:142700111-142705127 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit male infertility associated with impaired sperm migration into the oviduct.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    843
  • Tissues
    57
  • cDNA Data
    4
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 76486 NCBI Gene Model | MGI Sequence Detail 3095 C57BL/6J ±  kb
    transcript NM_029627 RefSeq | MGI Sequence Detail 773 C57BL/6  
    polypeptide Q9CWP4 UniProt | EBI | MGI Sequence Detail 154 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • InterPro Domains
      IPR016054 Ly-6 antigen/uPA receptor-like
      IPR045860 Snake toxin-like superfamily
      IPR052874 Sperm-binding zona pellucida regulatory protein
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 5
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1920400
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 8
      Phenotypes 28
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:307968 He Y, et al., Single-cell RNA-Seq reveals a highly coordinated transcriptional program in mouse germ cells during primordial follicle formation. Aging Cell. 2021 Jul;20(7):e13424
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory