Aoc1 MGI Mouse Gene Detail - MGI:1923757 - amine oxidase, copper-containing 1

Symbol

Aoc1
Name

amine oxidase, copper-containing 1
Synonyms

1600012D06Rik, Abp1

Feature Type

protein coding gene
IDs

MGI:1923757
NCBI Gene: 76507
Alliance

gene page
Transcription Start Sites

17 TSS

Sequence Map

Chr6:48872189-48886122 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 23.78 cM
Mapping Data

3 experiments

SNPs within 2kb

417 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1923757	protein coding gene	Chr6:48849830-48886122 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030715	protein coding gene	Chr6:47843615-47887235 (+)
A/J	MGP_AJ_G0030686	protein coding gene	Chr6:45664242-45700659 (+)
AKR/J	MGP_AKRJ_G0030611	protein coding gene	Chr6:47274662-47313215 (+)
BALB/cJ	MGP_BALBcJ_G0030696	protein coding gene	Chr6:45999354-46036288 (+)
C3H/HeJ	MGP_C3HHeJ_G0030409	protein coding gene	Chr6:47279037-47319479 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031151	protein coding gene	Chr6:48983345-49017651 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028358	protein coding gene	Chr6:43277703-43315325 (+)
CAST/EiJ	MGP_CASTEiJ_G0029813	protein coding gene	Chr6:47002731-47048670 (+)
CBA/J	MGP_CBAJ_G0030384	protein coding gene	Chr6:50991233-51040987 (+)
DBA/2J	MGP_DBA2J_G0030533	protein coding gene	Chr6:45580650-45618428 (+)
FVB/NJ	MGP_FVBNJ_G0030485	protein coding gene	Chr6:45217166-45254087 (+)
LP/J	MGP_LPJ_G0030618	protein coding gene	Chr6:47830481-47869032 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030519	protein coding gene	Chr6:53794878-53833106 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031180	protein coding gene	Chr6:47136042-47174112 (+)
PWK/PhJ	MGP_PWKPhJ_G0029525	protein coding gene	Chr6:45113091-45149956 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029361	protein coding gene	Chr6:46489109-46524259 (+)
WSB/EiJ	MGP_WSBEiJ_G0029890	protein coding gene	Chr6:47138266-47175123 (+)

Human Ortholog

AOC1, amine oxidase copper containing 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

AOC1, amine oxidase copper containing 1
Synonyms

ABP, ABP1, DAO, DAO1, KAO, KDAO
Links

HGNC:80

NCBI Gene ID: 26

neXtProt AC: NX_P19801

UniProt: P19801
Chr Location

7q36.1; chr7:150824627-150861504 (+) GRCh38

MGI Vertebrate Homology

Aoc1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: AOC1
Gene Tree

Aoc1

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

4
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

60 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

31
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

710
Tissues

2
cDNA Data

46
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase aoc1

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All Sequences

53
RefSeq

8
UniProt

5
CCDS

CCDS51767.1

Ensembl

ENSMUSG00000029811 (Evidence)
NCBI Gene

76507

			Length	Strain/Species	Flank
genomic	76507	NCBI Gene Model \| MGI Sequence Detail	13934	C57BL/6J	± kb
transcript	NM_001161621	RefSeq \| MGI Sequence Detail	2831	C57BL/6
polypeptide	Q8JZQ5	UniProt \| EBI \| MGI Sequence Detail	751	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000003588 amiloride-sensitive amine oxidase [copper-containing]

(term hierarchy)
EC

1.4.3.-, 1.4.3.22
InterPro Domains

IPR000269 Copper amine oxidase

IPR015798 Copper amine oxidase, catalytic domain

IPR036460 Copper amine oxidase, catalytic domain superfamily

IPR049947 Copper amine oxidase, copper-binding site

IPR015800 Copper amine oxidase, N2-terminal

IPR015802 Copper amine oxidase, N3-terminal

IPR016182 Copper amine oxidase, N-terminal

IPR049948 Copper amine oxidase, TPQ-binding site
GlyGen

Q8JZQ5 4 sites

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All nucleic 48

Genomic 1

cDNA 46

Primer pair 1

Microarray probesets 3

Summaries

All 43

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 9
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Aoc1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr56240	Chr6:48872148-48872167 (+)	-31 bp
Tssr56241	Chr6:48872177-48872198 (+)	-1 bp
Tssr56242	Chr6:48881894-48881907 (+)	9,712 bp
Tssr56243	Chr6:48881913-48881925 (+)	9,730 bp
Tssr56244	Chr6:48882067-48882077 (+)	9,883 bp
Tssr56245	Chr6:48883016-48883027 (+)	10,833 bp
Tssr56246	Chr6:48883029-48883046 (+)	10,849 bp
Tssr56247	Chr6:48883090-48883101 (+)	10,907 bp
Tssr56248	Chr6:48883468-48883480 (+)	11,285 bp
Tssr56249	Chr6:48884599-48884602 (+)	12,412 bp
Tssr56250	Chr6:48884610-48884615 (+)	12,424 bp
Tssr56251	Chr6:48884641-48884650 (+)	12,457 bp
Tssr56252	Chr6:48884662-48884689 (+)	12,487 bp
Tssr56253	Chr6:48884731-48884740 (+)	12,547 bp
Tssr56254	Chr6:48884746-48884755 (+)	12,562 bp
Tssr56255	Chr6:48885769-48885779 (+)	13,585 bp
Tssr56256	Chr6:48885781-48885803 (+)	13,603 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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