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Styxl1 Gene Detail
Summary
  • Symbol
    Styxl1
  • Name
    serine/threonine/tyrosine interacting-like 1
  • Synonyms
    1700011C14Rik, Dusp24
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923821
    NCBI Gene: 76571
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:135776074-135807239 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 75.38 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    889 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923821
 protein coding gene Chr5:135776074-135807277 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030189
 protein coding gene Chr5:140330088-140363055 (-)
A/J MGP_AJ_G0030157
 protein coding gene Chr5:134303757-134333973 (-)
AKR/J MGP_AKRJ_G0030090
 protein coding gene Chr5:138649610-138683287 (-)
BALB/cJ MGP_BALBcJ_G0030167
 protein coding gene Chr5:135655006-135685773 (-)
C3H/HeJ MGP_C3HHeJ_G0029883
 protein coding gene Chr5:139232195-139267162 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030620
 protein coding gene Chr5:145556789-145593144 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027843
 protein coding gene Chr5:128587412-128622656 (-)
CAST/EiJ MGP_CASTEiJ_G0029293
 protein coding gene Chr5:138639428-138674141 (-)
CBA/J MGP_CBAJ_G0029853
 protein coding gene Chr5:151220576-151254451 (-)
DBA/2J MGP_DBA2J_G0030004
 protein coding gene Chr5:134197451-134228935 (-)
FVB/NJ MGP_FVBNJ_G0029959
 protein coding gene Chr5:133344888-133376499 (-)
LP/J MGP_LPJ_G0030093
 protein coding gene Chr5:140760299-140797589 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029991
 protein coding gene Chr5:154228822-154270385 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030660
 protein coding gene Chr5:138437281-138470030 (-)
PWK/PhJ MGP_PWKPhJ_G0029007
 protein coding gene Chr5:133258152-133289820 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028842
 protein coding gene Chr5:135968858-136012341 (-)
WSB/EiJ MGP_WSBEiJ_G0029366
 protein coding gene Chr5:139160477-139195907 (-)



Homology
more
  • Human Ortholog
    STYXL1, serine/threonine/tyrosine interacting like 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    STYXL1, serine/threonine/tyrosine interacting like 1
  • Synonyms
    DUSP24, MK-STYX, MKSTYX
  • Links
    NCBI Gene ID: 51657
    neXtProt AC: NX_Q9Y6J8
    UniProt: Q9Y6J8

  • Chr Location
    7q11.23; chr7:75996337-76048004 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 3 alleles in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display male infertility with oligoasthenoteratozoospermia, with defects in axoneme microtubule formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000019178 Ensembl Gene Model | MGI Sequence Detail 31166 C57BL/6J ±  kb
    transcript ENSMUST00000111163 Ensembl | MGI Sequence Detail 1276 Not Applicable  
    polypeptide ENSMUSP00000106793 Ensembl | MGI Sequence Detail 321 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • InterPro Domains
      IPR000340 Dual specificity phosphatase, catalytic domain
      IPR020422 Dual specificity protein phosphatase domain
      IPR029021 Protein-tyrosine phosphatase-like
      IPR001763 Rhodanese-like domain
      IPR036873 Rhodanese-like domain superfamily
      IPR053272 Serine/threonine/tyrosine-interacting-like protein
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 7

      Microarray probesets 2
    References
    more
    • Summaries
      All 25
      Gene Ontology 2
      Phenotypes 7
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:351148 Chen Y, et al., STYXL1 regulates CCT complex assembly and flagellar tubulin folding in sperm formation. Nat Commun. 2024 Jan 2;15(1):44
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory