Rbmxl2 MGI Mouse Gene Detail - MGI:1923822 - RNA binding motif protein, X-linked-like 2

Symbol

Rbmxl2
Name

RNA binding motif protein, X-linked-like 2
Synonyms

1700012H05Rik

Feature Type

protein coding gene
IDs

MGI:1923822
NCBI Gene: 76572
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr7:106808652-106810123 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 56.10 cM
Mapping Data

1 experiment

SNPs within 2kb

46 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1923822	protein coding gene	Chr7:106808652-106810123 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032794	protein coding gene	Chr7:110551516-110555768 (+)
A/J	MGP_AJ_G0032775	protein coding gene	Chr7:107803737-107805212 (+)
AKR/J	MGP_AKRJ_G0032707	protein coding gene	Chr7:110512529-110514004 (+)
BALB/cJ	MGP_BALBcJ_G0032781	protein coding gene	Chr7:107507598-107509073 (+)
C3H/HeJ	MGP_C3HHeJ_G0032490	protein coding gene	Chr7:110525885-110527360 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033286	protein coding gene	Chr7:115113437-115114908 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030264	protein coding gene	Chr7:109480832-109482308 (+)
CAST/EiJ	MGP_CASTEiJ_G0031821	protein coding gene	Chr7:102127872-102129343 (+)
CBA/J	MGP_CBAJ_G0032465	protein coding gene	Chr7:118906005-118907480 (+)
DBA/2J	MGP_DBA2J_G0032616	protein coding gene	Chr7:105936989-105938500 (+)
FVB/NJ	MGP_FVBNJ_G0032568	protein coding gene	Chr7:105776629-105778100 (+)
LP/J	MGP_LPJ_G0032708	protein coding gene	Chr7:112140702-112142177 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032602	protein coding gene	Chr7:120543740-120545265 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033305	protein coding gene	Chr7:109569798-109571273 (+)
PWK/PhJ	MGP_PWKPhJ_G0031527	protein coding gene	Chr7:98815239-98816730 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031377	protein coding gene	Chr7:96175202-96176677 (+)
WSB/EiJ	MGP_WSBEiJ_G0031936	protein coding gene	Chr7:110309765-110311240 (+)

Human Ortholog

RBMXL2, RBMX like 2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RBMXL2, RBMX like 2
Synonyms

HNRNPG-T, HNRNPGT, HNRPGT
Links

HGNC:17886

NCBI Gene ID: 27288

neXtProt AC: NX_O75526

UniProt: O75526
Chr Location

11p15.4; chr11:7088998-7091148 (+) GRCh38

MGI Vertebrate Homology

Rbmxl2 stringent orthology
1 human;1 mouse;1 zebrafish
HCOP

vertebrate homology predictions: RBMXL2
Gene Tree

Rbmxl2

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

1
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Rbmxl2
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

11 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit male infertility and azoospermia due to arrested male meiosis, male germ cell apoptosis and mis-splicing in testes cells.

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All GO Annotations

3
GO References

1

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

728
Tissues

22
cDNA Data

6
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas

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All Sequences

27
RefSeq

2
UniProt

1
CCDS

CCDS21689.1

Ensembl

ENSMUSG00000073894 (Evidence)
NCBI Gene

76572

			Length	Strain/Species	Flank
genomic	76572	NCBI Gene Model \| MGI Sequence Detail	1472	C57BL/6J	± kb
transcript	NM_029660	RefSeq \| MGI Sequence Detail	1472	C57BL/6
polypeptide	NP_083936	RefSeq \| MGI Sequence Detail	385	C57BL/6

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UniProt

1 Sequence
InterPro Domains

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR012604 RBM1CTR

IPR035979 RNA-binding domain superfamily

IPR050441 RNA-binding motif

IPR000504 RNA recognition motif domain

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All nucleic 7

cDNA 6

Primer pair 1

Microarray probesets 3

Summaries

All 29

Developmental Gene Expression 1

Gene Ontology 1

Phenotypes 12
Earliest

J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
Latest

J:275203 Ehrmann I, et al., An ancient germ cell-specific RNA-binding protein protects the germline from cryptic splice site poisoning. Elife. 2019 Jan 24;8:e39304

TSS for Rbmxl2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr68407	Chr7:106808374-106808384 (+)	-273 bp
Tssr68408	Chr7:106808389-106808406 (+)	-254 bp
Tssr68409	Chr7:106808584-106808590 (+)	-65 bp
Tssr68410	Chr7:106808591-106808611 (+)	-51 bp
Tssr68411	Chr7:106808646-106808658 (+)	0 bp
Tssr68412	Chr7:106808675-106808691 (+)	31 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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