Faf2 MGI Mouse Gene Detail - MGI:1923827 - Fas associated factor family member 2

Symbol

Faf2
Name

Fas associated factor family member 2
Synonyms

2210404D11Rik, mKIAA0887, Ubxd8

Feature Type

protein coding gene
IDs

MGI:1923827
NCBI Gene: 76577
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr13:54769597-54811876 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 28.88 cM
Mapping Data

2 experiments

SNPs within 2kb

1009 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1923827	protein coding gene	Chr13:54769597-54811876 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020575	protein coding gene	Chr13:54027936-54073416 (+)
A/J	MGP_AJ_G0020529	protein coding gene	Chr13:52047276-52089403 (+)
AKR/J	MGP_AKRJ_G0020507	protein coding gene	Chr13:53576760-53625837 (+)
BALB/cJ	MGP_BALBcJ_G0020525	protein coding gene	Chr13:52280635-52326032 (+)
C3H/HeJ	MGP_C3HHeJ_G0020324	protein coding gene	Chr13:53402250-53449402 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020959	protein coding gene	Chr13:55685978-55733813 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018541	protein coding gene	Chr13:50043924-50090067 (+)
CAST/EiJ	MGP_CASTEiJ_G0019838	protein coding gene	Chr13:53485041-53530579 (+)
CBA/J	MGP_CBAJ_G0020284	protein coding gene	Chr13:57802752-57848570 (+)
DBA/2J	MGP_DBA2J_G0020407	protein coding gene	Chr13:51615752-51658045 (+)
FVB/NJ	MGP_FVBNJ_G0020386	protein coding gene	Chr13:51063183-51106282 (+)
LP/J	MGP_LPJ_G0020483	protein coding gene	Chr13:54304188-54349876 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020415	protein coding gene	Chr13:57300307-57345281 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021002	protein coding gene	Chr13:53172570-53218923 (+)
PWK/PhJ	MGP_PWKPhJ_G0019594	protein coding gene	Chr13:51603058-51648135 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019421	protein coding gene	Chr13:52086459-52134142 (+)
WSB/EiJ	MGP_WSBEiJ_G0019900	protein coding gene	Chr13:53510712-53553646 (+)

Human Ortholog

FAF2, Fas associated factor family member 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FAF2, Fas associated factor family member 2
Synonyms

ETEA, UBXD8, UBXN3B
Links

HGNC:24666

NCBI Gene ID: 23197

neXtProt AC: NX_Q96CS3

UniProt: Q96CS3
Chr Location

5q35.2; chr5:176447628-176510074 (+) GRCh38

MGI Vertebrate Homology

Faf2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FAF2
Gene Tree

Faf2

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References

1 with disease annotations

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Phenotype Summary

32 phenotypes from 2 alleles in 2 genetic backgrounds
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

25
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

19
Targeted

2
Transgenic

1
Genomic Mutations

2 involving Faf2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

24 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a conditional allele activated in the liver exhibit high-fat diet-induced periportal steatosis with reduced circulating lipid levels and ApoB secretion.

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All GO Annotations

27
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

172

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase faf2

ZFIN faf2

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All Sequences

73
RefSeq

16
UniProt

6
CCDS

CCDS36668.1

Ensembl

ENSMUSG00000025873 (Evidence)
NCBI Gene

76577

			Length	Strain/Species	Flank
genomic	76577	NCBI Gene Model \| MGI Sequence Detail	42280	C57BL/6J	± kb
transcript	NM_178397	RefSeq \| MGI Sequence Detail	4322	C57BL/6
polypeptide	Q3TDN2	UniProt \| EBI \| MGI Sequence Detail	445	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000007322 FAS-associated factor 2

(term hierarchy)
InterPro Domains

IPR049483 Fas-associated factor 1/2-like, UAS domain

IPR036249 Thioredoxin-like superfamily

IPR006577 UAS

IPR009060 UBA-like superfamily

IPR029071 Ubiquitin-like domain superfamily

IPR001012 UBX domain

IPR050730 UBX domain-containing protein
GlyGen

Q3TDN2 1 site, 1 N-linked glycan (1 site)

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All nucleic 174

Genomic 1

cDNA 173

Microarray probesets 5

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MGI:2145252

Summaries

All 49

Diseases 1

Gene Ontology 8

Phenotypes 17
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:354634 Geng T, et al., UBXN3B is crucial for B lymphopoiesis. EBioMedicine. 2024 Jul 16;106:105248

TSS for Faf2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr119883	Chr13:54769593-54769606 (+)	3 bp
Tssr119884	Chr13:54769614-54769654 (+)	37 bp
Tssr119885	Chr13:54781110-54781114 (+)	11,515 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24