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Immt Gene Detail
Summary
  • Symbol
    Immt
  • Name
    inner membrane protein, mitochondrial
  • Synonyms
    1700082C19Rik, D830041H16Rik, HMP, Micos60, mitofilin, P87, P87/89, P89
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923864
    NCBI Gene: 76614
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:71806200-71852250 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 32.21 cM, cytoband C3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1121 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923864
 protein coding gene Chr6:71806200-71854372 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030864
 protein coding gene Chr6:72337501-72386247 (+)
A/J MGP_AJ_G0030834
 protein coding gene Chr6:69550950-69599467 (+)
AKR/J MGP_AKRJ_G0030763
 protein coding gene Chr6:71566370-71616789 (+)
BALB/cJ MGP_BALBcJ_G0030845
 protein coding gene Chr6:69580739-69627399 (+)
C3H/HeJ MGP_C3HHeJ_G0030867
 protein coding gene Chr6:112632009-112683142 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031303
 protein coding gene Chr6:74241456-74288669 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028492
 protein coding gene Chr6:68718627-68765677 (+)
CAST/EiJ MGP_CASTEiJ_G0029953
 protein coding gene Chr6:71435754-71489419 (+)
CBA/J MGP_CBAJ_G0030532
 protein coding gene Chr6:77213901-77269981 (+)
DBA/2J MGP_DBA2J_G0030684
 protein coding gene Chr6:68932986-68979940 (+)
FVB/NJ MGP_FVBNJ_G0030637
 protein coding gene Chr6:68314867-68363587 (+)
LP/J MGP_LPJ_G0030763
 protein coding gene Chr6:72254356-72302115 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030672
 protein coding gene Chr6:80679966-80730002 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031329
 protein coding gene Chr6:71394233-71440459 (+)
PWK/PhJ MGP_PWKPhJ_G0029669
 protein coding gene Chr6:67829938-67879270 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029497
 protein coding gene Chr6:70113036-70162718 (+)
WSB/EiJ MGP_WSBEiJ_G0030035
 protein coding gene Chr6:71753185-71800435 (+)



Homology
more
  • Human Ortholog
    IMMT, inner membrane mitochondrial protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IMMT, inner membrane mitochondrial protein
  • Synonyms
    HMP, Mic60, MICOS60, MINOS2, P87, P87/89, P89, PIG4, PIG52
  • Links
    NCBI Gene ID: 10989
    neXtProt AC: NX_Q16891
    UniProt: Q16891

  • Chr Location
    2p11.2; chr2:86143932-86195472 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    37 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Embryos homozygous for a gene trapped allele show decreased size, massive apoptosis and complete embryonic lethality during organogenesis. Heterozygotes exhibit progressive neurological defects, altered brain structure, neuron loss, impaired mitochondrial structure and function, oxidative stress, and metabolic alterations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    863
  • Tissues
    22
  • cDNA Data
    22
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 76614 NCBI Gene Model | MGI Sequence Detail 46051 C57BL/6J ±  kb
    transcript NM_029673 RefSeq | MGI Sequence Detail 2777 C57BL/6  
    polypeptide Q8CAQ8 UniProt | EBI | MGI Sequence Detail 757 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      16 Sequences
    • Protein Ontology
      PR:000009014 MICOS complex subunit MIC60
      (term hierarchy)
    • InterPro Domains
      IPR019133 MICOS complex subunit MIC60
    • GlyGen
      Q8CAQ8 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 25
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2441994
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 2
      Gene Ontology 11
      Phenotypes 14
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:344896 Dong T, et al., Mic60 is essential to maintain mitochondrial integrity and to prevent encephalomyopathy. Brain Pathol. 2023 Jul;33(4):e13157
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory