Got1l1 MGI Mouse Gene Detail - MGI:1923865 - glutamic-oxaloacetic transaminase 1-like 1

Symbol

Got1l1
Name

glutamic-oxaloacetic transaminase 1-like 1
Synonyms

1700083M11Rik

Feature Type

protein coding gene
IDs

MGI:1923865
NCBI Gene: 76615
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr8:27687487-27713856 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 15.92 cM, cytoband A3
Mapping Data

3 experiments

SNPs within 2kb

909 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1923865	protein coding gene	Chr8:27687487-27713872 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0033504	protein coding gene	Chr8:25386359-25391482 (-)
A/J	MGP_AJ_G0033484	protein coding gene	Chr8:24418407-24423493 (-)
AKR/J	MGP_AKRJ_G0033409	protein coding gene	Chr8:25239701-25244797 (-)
BALB/cJ	MGP_BALBcJ_G0033480	protein coding gene	Chr8:24587825-24592908 (-)
C3H/HeJ	MGP_C3HHeJ_G0033194	protein coding gene	Chr8:25448870-25453965 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0033996	protein coding gene	Chr8:26366756-26371841 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030946	protein coding gene	Chr8:21666861-21672269 (-)
CAST/EiJ	MGP_CASTEiJ_G0032520	protein coding gene	Chr8:24940388-24945510 (-)
CBA/J	MGP_CBAJ_G0033169	protein coding gene	Chr8:27414168-27419242 (-)
DBA/2J	MGP_DBA2J_G0033324	protein coding gene	Chr8:24387865-24392957 (-)
FVB/NJ	MGP_FVBNJ_G0033268	protein coding gene	Chr8:24198174-24203252 (-)
LP/J	MGP_LPJ_G0033413	protein coding gene	Chr8:25344708-25349789 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033311	protein coding gene	Chr8:26851204-26856318 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034015	protein coding gene	Chr8:25212254-25217366 (-)
PWK/PhJ	MGP_PWKPhJ_G0032231	protein coding gene	Chr8:24048812-24053965 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0032065	protein coding gene	Chr8:24592487-24597670 (-)
WSB/EiJ	MGP_WSBEiJ_G0032636	protein coding gene	Chr8:25399359-25404446 (-)

Human Ortholog

GOT1L1, glutamic-oxaloacetic transaminase 1 like 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GOT1L1, glutamic-oxaloacetic transaminase 1 like 1
Links

HGNC:28487

NCBI Gene ID: 137362

neXtProt AC: NX_Q8NHS2

UniProt: Q8NHS2
Chr Location

8p11.23; chr8:37934281-37940124 (-) GRCh38

MGI Vertebrate Homology

Got1l1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GOT1L1
Gene Tree

Got1l1

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

1
Gene trapped

6
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

23 strains or lines available

Mice homozygous for a null allele exhbit slight decreased glutamate and glutamine levels in the hippocampus.

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All GO Annotations

9
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

7

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

42
RefSeq

10
UniProt

2
CCDS

CCDS22212.1

Ensembl

ENSMUSG00000039720 (Evidence)
NCBI Gene

76615

			Length	Strain/Species	Flank
genomic	ENSMUSG00000039720	Ensembl Gene Model \| MGI Sequence Detail	26370	C57BL/6J	± kb
transcript	ENSMUST00000038174	Ensembl \| MGI Sequence Detail	1356	Not Applicable
polypeptide	ENSMUSP00000041337	Ensembl \| MGI Sequence Detail	404	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000031376 putative aspartate aminotransferase, cytoplasmic 2

(term hierarchy)
EC

2.6.1.1
InterPro Domains

IPR004839 Aminotransferase, class I/classII

IPR000796 Aspartate/other aminotransferase

IPR015424 Pyridoxal phosphate-dependent transferase

IPR015421 Pyridoxal phosphate-dependent transferase, major domain

IPR015422 Pyridoxal phosphate-dependent transferase, small domain

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All nucleic 7

cDNA 7

Microarray probesets 2

Summaries

All 29

Gene Ontology 5

Phenotypes 6
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:301627 Tanaka-Hayashi A, et al., Is D-aspartate produced by glutamic-oxaloacetic transaminase-1 like 1 (Got1l1): a putative aspartate racemase?. Amino Acids. 2015 Jan;47(1):79-86

TSS for Got1l1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr80791	Chr8:27713842-27713861 (-)	4 bp
Tssr80790	Chr8:27713812-27713826 (-)	37 bp
Tssr80789	Chr8:27692595-27692609 (-)	21,254 bp
Tssr80788	Chr8:27692570-27692585 (-)	21,278 bp
Tssr80787	Chr8:27692552-27692563 (-)	21,298 bp
Tssr80786	Chr8:27692506-27692509 (-)	21,348 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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