Lrmda Gene Detail

Summary

• Symbol
  Lrmda
• Name
  leucine rich melanocyte differentiation associated
• Synonyms
  1700112E06Rik, 2700009F18Rik, Oca7

• Feature Type
  protein coding gene
• IDs
  MGI:1923883
  NCBI Gene: 76633
• Alliance
  gene page
• Transcription Start Sites
  105 TSS

Location &
Maps

• Sequence Map
  Chr14:22069780-23106153 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 14, 12.03 cM, cytoband B
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  25066 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1923883	protein coding gene	Chr14:22069567-23106161 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021059	protein coding gene	Chr14:14868160-15942365 (+)
A/J	MGP_AJ_G0021008	protein coding gene	Chr14:14482448-15517753 (+)
AKR/J	MGP_AKRJ_G0020985	protein coding gene	Chr14:15052296-16097638 (+)
BALB/cJ	MGP_BALBcJ_G0021011	protein coding gene	Chr14:14583694-15635576 (+)
C3H/HeJ	MGP_C3HHeJ_G0020795	protein coding gene	Chr14:14976432-16052236 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021444	protein coding gene	Chr14:15355539-16461045 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019012	protein coding gene	Chr14:14796555-15816438 (+)
CAST/EiJ	MGP_CASTEiJ_G0020319	protein coding gene	Chr14:14795653-15868558 (+)
CBA/J	MGP_CBAJ_G0020761	protein coding gene	Chr14:16143706-17287196 (+)
DBA/2J	MGP_DBA2J_G0020884	protein coding gene	Chr14:14308394-15344739 (+)
FVB/NJ	MGP_FVBNJ_G0020867	protein coding gene	Chr14:14198355-15217313 (+)
LP/J	MGP_LPJ_G0020960	protein coding gene	Chr14:15086705-16167632 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020893	protein coding gene	Chr14:15878525-17042645 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021477	protein coding gene	Chr14:14832950-15904282 (+)
PWK/PhJ	MGP_PWKPhJ_G0020068	protein coding gene	Chr14:13913588-14952567 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019890	protein coding gene	Chr14:14655946-15712431 (+)
WSB/EiJ	MGP_WSBEiJ_G0020375	protein coding gene	Chr14:14831803-15906471 (+)

Homology

• Human Ortholog
  LRMDA, leucine rich melanocyte differentiation associated

• Vertebrate Orthologs
  2

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  LRMDA, leucine rich melanocyte differentiation associated
  
• Synonyms
  C10orf11, CDA017
• Links
  HGNC:23405

  NCBI Gene ID: 83938

  neXtProt AC: NX_Q9H2I8

  UniProt: Q9H2I8

  
  
• Chr Location
  10q22.2-q22.3; chr10:75431624-76560168 (+)  GRCh38

---

• MGI Vertebrate Homology
  Lrmda stringent orthology
  1 human;1 mouse;1 zebrafish
  
• HCOP
  vertebrate homology predictions: LRMDA
• Gene Tree
  Lrmda
  

Human Diseases

• Diseases
  1 with human LRMDA associations

				Human Disease	Mouse Models
				oculocutaneous albinism type VII IDs oculocutaneous albinism type VII       DOID:0070100 OMIM:615179

Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  2 phenotypes from 1 allele in 1 genetic background
  8 phenotype references
  

• All Mutations and Alleles
  11
• Endonuclease-mediated
  2
• Gene trapped
  7
• Targeted
  2
• Incidental Mutations
  APF
• Find Mice (IMSR)
  20 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Gene Ontology
(GO)
Classifications

• All GO Annotations
  3
• GO References
  3

Expression

• Assay Results
  707
• Tissues
  1
• cDNA Data
  6
• Literature Summary
  1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase lrmda

Sequences &
Gene Models

• All Sequences
  57
• RefSeq
  14
• UniProt
  5
• CCDS
  CCDS49415.1

• Ensembl
  ENSMUSG00000063458 (Evidence)
• NCBI Gene
  76633

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000063458	Ensembl Gene Model | MGI Sequence Detail	1036374	C57BL/6J
transcript	ENSMUST00000075639	Ensembl | MGI Sequence Detail	908	Not Applicable
polypeptide	ENSMUSP00000075065	Ensembl | MGI Sequence Detail	229	Not Applicable

Protein
Information

• UniProt
  5 Sequences
• Protein Ontology
  PR:000060074 leucine-rich melanocyte differentiation-associated protein
  (term hierarchy)
• InterPro Domains
  IPR043313 Leucine-rich melanocyte differentiation-associated protein
  IPR001611 Leucine-rich repeat
  IPR032675 Leucine-rich repeat domain superfamily

Molecular
Reagents

• All nucleic 6

  cDNA 6

  
  

  Microarray probesets 5

Other
Accession IDs

MGI:1919796, MGI:5883028

References

• Summaries
  All 34

  Developmental Gene Expression 1

  Gene Ontology 3

  Phenotypes 8
• Earliest
  J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
• Latest
  J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Lrmda:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr4341	Chr14:22069709-22069712 (+)	-69 bp
Tssr124464	Chr14:22069859-22069876 (+)	88 bp
Tssr124465	Chr14:22069877-22069900 (+)	109 bp
Tssr124466	Chr14:22069901-22069924 (+)	133 bp
Tssr124467	Chr14:22072774-22072778 (+)	2,996 bp
Tssr124470	Chr14:22114118-22114142 (+)	44,350 bp
Tssr124471	Chr14:22129861-22129889 (+)	60,095 bp
Tssr124472	Chr14:22129915-22129944 (+)	60,150 bp
Tssr124473	Chr14:22141267-22141274 (+)	71,491 bp
Tssr124474	Chr14:22150714-22150727 (+)	80,941 bp
Tssr124475	Chr14:22150820-22150831 (+)	81,046 bp
Tssr124476	Chr14:22151004-22151025 (+)	81,235 bp
Tssr124477	Chr14:22163514-22163522 (+)	93,738 bp
Tssr124478	Chr14:22164396-22164398 (+)	94,617 bp
Tssr124479	Chr14:22170502-22170513 (+)	100,728 bp
Tssr124480	Chr14:22172231-22172242 (+)	102,457 bp
Tssr124481	Chr14:22172501-22172521 (+)	102,731 bp
Tssr124482	Chr14:22172906-22172920 (+)	103,133 bp
Tssr124483	Chr14:22173296-22173308 (+)	103,522 bp
Tssr124484	Chr14:22173369-22173388 (+)	103,599 bp
Tssr124485	Chr14:22173845-22173859 (+)	104,072 bp
Tssr124486	Chr14:22173941-22173958 (+)	104,170 bp
Tssr124487	Chr14:22185795-22185797 (+)	116,016 bp
Tssr124488	Chr14:22190238-22190251 (+)	120,465 bp
Tssr124489	Chr14:22190325-22190353 (+)	120,559 bp
Tssr124490	Chr14:22190401-22190412 (+)	120,627 bp
Tssr124491	Chr14:22190929-22190952 (+)	121,161 bp
Tssr124492	Chr14:22191571-22191616 (+)	121,814 bp
Tssr124493	Chr14:22193194-22193206 (+)	123,420 bp
Tssr124494	Chr14:22208794-22208831 (+)	139,033 bp
Tssr124495	Chr14:22209151-22209163 (+)	139,377 bp
Tssr124496	Chr14:22209175-22209189 (+)	139,402 bp
Tssr124497	Chr14:22213524-22213546 (+)	143,755 bp
Tssr124498	Chr14:22214167-22214196 (+)	144,402 bp
Tssr124499	Chr14:22214973-22214998 (+)	145,206 bp
Tssr124500	Chr14:22215002-22215021 (+)	145,232 bp
Tssr124501	Chr14:22215039-22215071 (+)	145,275 bp
Tssr124502	Chr14:22229001-22229007 (+)	159,224 bp
Tssr124503	Chr14:22230404-22230409 (+)	160,627 bp
Tssr124504	Chr14:22231763-22231765 (+)	161,984 bp
Tssr124505	Chr14:22234553-22234576 (+)	164,785 bp
Tssr124506	Chr14:22235193-22235201 (+)	165,417 bp
Tssr124507	Chr14:22236013-22236020 (+)	166,237 bp
Tssr124508	Chr14:22236629-22236636 (+)	166,853 bp
Tssr124509	Chr14:22245933-22245949 (+)	176,161 bp
Tssr124510	Chr14:22251994-22252005 (+)	182,220 bp
Tssr124511	Chr14:22252260-22252276 (+)	182,488 bp
Tssr124512	Chr14:22252278-22252292 (+)	182,505 bp
Tssr124513	Chr14:22253273-22253276 (+)	183,495 bp
Tssr124514	Chr14:22262550-22262598 (+)	192,794 bp
Tssr124515	Chr14:22264277-22264282 (+)	194,500 bp
Tssr124516	Chr14:22264358-22264381 (+)	194,590 bp
Tssr124517	Chr14:22264387-22264425 (+)	194,626 bp
Tssr124518	Chr14:22270696-22270699 (+)	200,918 bp
Tssr124519	Chr14:22272388-22272408 (+)	202,618 bp
Tssr124520	Chr14:22274675-22274687 (+)	204,901 bp
Tssr124521	Chr14:22275088-22275119 (+)	205,324 bp
Tssr124522	Chr14:22290733-22290742 (+)	220,958 bp
Tssr124523	Chr14:22291045-22291056 (+)	221,271 bp
Tssr124524	Chr14:22296918-22296932 (+)	227,145 bp
Tssr124525	Chr14:22297083-22297090 (+)	227,307 bp
Tssr124526	Chr14:22303015-22303037 (+)	233,246 bp
Tssr124527	Chr14:22308906-22308939 (+)	239,143 bp
Tssr124528	Chr14:22325258-22325269 (+)	255,484 bp
Tssr124529	Chr14:22358291-22358293 (+)	288,512 bp
Tssr124530	Chr14:22358335-22358338 (+)	288,557 bp
Tssr124531	Chr14:22360801-22360815 (+)	291,028 bp
Tssr124532	Chr14:22360894-22360909 (+)	291,122 bp
Tssr124533	Chr14:22360944-22360962 (+)	291,173 bp
Tssr124534	Chr14:22361009-22361042 (+)	291,246 bp
Tssr124535	Chr14:22368503-22368522 (+)	298,733 bp
Tssr124536	Chr14:22368739-22368750 (+)	298,965 bp
Tssr124537	Chr14:22368778-22368791 (+)	299,005 bp
Tssr124538	Chr14:22368796-22368820 (+)	299,028 bp
Tssr124539	Chr14:22370742-22370752 (+)	300,967 bp
Tssr124540	Chr14:22375477-22375486 (+)	305,702 bp
Tssr124541	Chr14:22380745-22380768 (+)	310,977 bp
Tssr124542	Chr14:22380972-22381020 (+)	311,216 bp
Tssr124543	Chr14:22399824-22399845 (+)	330,055 bp
Tssr124544	Chr14:22400689-22400700 (+)	330,915 bp
Tssr124545	Chr14:22415202-22415213 (+)	345,428 bp
Tssr124546	Chr14:22415277-22415335 (+)	345,526 bp
Tssr124547	Chr14:22415399-22415423 (+)	345,631 bp
Tssr124548	Chr14:22419387-22419389 (+)	349,608 bp
Tssr124549	Chr14:22421770-22421782 (+)	351,996 bp
Tssr124550	Chr14:22421913-22421961 (+)	352,157 bp
Tssr124551	Chr14:22422015-22422021 (+)	352,238 bp
Tssr124552	Chr14:22428235-22428240 (+)	358,458 bp
Tssr124553	Chr14:22444317-22444325 (+)	374,541 bp
Tssr124554	Chr14:22455531-22455534 (+)	385,753 bp
Tssr124555	Chr14:22478814-22478824 (+)	409,039 bp
Tssr124556	Chr14:22483109-22483122 (+)	413,336 bp
Tssr124557	Chr14:22488735-22488746 (+)	418,961 bp
Tssr124558	Chr14:22488764-22488779 (+)	418,992 bp
Tssr124559	Chr14:22505959-22505964 (+)	436,182 bp
Tssr124560	Chr14:22516409-22516431 (+)	446,640 bp
Tssr124561	Chr14:22518933-22518958 (+)	449,166 bp
Tssr124562	Chr14:22597421-22597427 (+)	527,644 bp
Tssr124563	Chr14:22666445-22666463 (+)	596,674 bp
Tssr124564	Chr14:22745108-22745119 (+)	675,334 bp
Tssr124565	Chr14:22772475-22772485 (+)	702,700 bp
Tssr124566	Chr14:22792806-22792811 (+)	723,029 bp
Tssr124567	Chr14:22822860-22822863 (+)	753,082 bp
Tssr124568	Chr14:22879436-22879442 (+)	809,659 bp
Tssr124569	Chr14:22987511-22987522 (+)	917,737 bp