About   Help   FAQ
Upp2 Gene Detail
Summary
  • Symbol
    Upp2
  • Name
    uridine phosphorylase 2
  • Synonyms
    1700124F02Rik, UDRPASE2, UP2, UPASE2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923904
    NCBI Gene: 76654
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:58457310-58682983 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 33.16 cM, cytoband C3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6046 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923904
 protein coding gene Chr2:58456329-58685858 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025751
 protein coding gene Chr2:58112179-58353708 (+)
A/J MGP_AJ_G0025727
 protein coding gene Chr2:55883160-56094684 (+)
AKR/J MGP_AKRJ_G0025697
 protein coding gene Chr2:57421181-57646163 (+)
BALB/cJ MGP_BALBcJ_G0025722
 protein coding gene Chr2:55996798-56218498 (+)
C3H/HeJ MGP_C3HHeJ_G0025483
 protein coding gene Chr2:57519091-57748155 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026169
 protein coding gene Chr2:59866735-60099917 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023574
 protein coding gene Chr2:53478830-53697037 (+)
CAST/EiJ MGP_CASTEiJ_G0024948
 protein coding gene Chr2:57542710-57771378 (+)
CBA/J MGP_CBAJ_G0025463
 protein coding gene Chr2:62099850-62351520 (+)
DBA/2J MGP_DBA2J_G0025594
 protein coding gene Chr2:55504227-55730598 (+)
FVB/NJ MGP_FVBNJ_G0025556
 protein coding gene Chr2:55037492-55259021 (+)
LP/J MGP_LPJ_G0025682
 protein coding gene Chr2:57985257-58214298 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025587
 protein coding gene Chr2:63812673-64039883 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026226
 protein coding gene Chr2:57432950-57662803 (+)
PWK/PhJ MGP_PWKPhJ_G0024689
 protein coding gene Chr2:55326295-55543322 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024495
 protein coding gene Chr2:57528316-57746914 (+)
WSB/EiJ MGP_WSBEiJ_G0025015
 protein coding gene Chr2:57711160-57940964 (+)



Homology
more
  • Human Ortholog
    UPP2, uridine phosphorylase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UPP2, uridine phosphorylase 2
  • Synonyms
    UDRPASE2, UP2, UPASE2
  • Links
    NCBI Gene ID: 151531
    neXtProt AC: NX_O95045
    UniProt: O95045

  • Chr Location
    2q24.1; chr2:157876679-158136154 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    94
  • cDNA Data
    10
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026839 Ensembl Gene Model | MGI Sequence Detail 225674 C57BL/6J ±  kb
transcript ENSMUST00000059102 Ensembl | MGI Sequence Detail 2498 Not Applicable  
polypeptide ENSMUSP00000060437 Ensembl | MGI Sequence Detail 338 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 10
    cDNA 10

    Microarray probesets 7
Other
Accession IDs
less
MGI:2138873
References
more
  • Summaries
    All 37
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:346985 Zhao H, et al., Identification of BMAL1-Regulated circadian genes in mouse liver and their potential association with hepatocellular carcinoma: Gys2 and Upp2 as promising candidates. Biochem Biophys Res Commun. 2023 Dec 25;696:149422
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory