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Eif4g3 Gene Detail
Summary
  • Symbol
    Eif4g3
  • Name
    eukaryotic translation initiation factor 4 gamma, 3
  • Synonyms
    1500002J22Rik, 4930523M17Rik, eIF4GII, G1-419-52, repro8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923935
    NCBI Gene: 230861
  • Alliance
    gene page
  • Transcription Start Sites
    32 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:137719090-137934397 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 70.02 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6085 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923935
 protein coding gene Chr4:137719090-137935819 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028989
 protein coding gene Chr4:140691013-140921575 (+)
A/J MGP_AJ_G0028948
 protein coding gene Chr4:134690804-134907078 (+)
AKR/J MGP_AKRJ_G0028900
 protein coding gene Chr4:138537898-138756780 (+)
BALB/cJ MGP_BALBcJ_G0028972
 protein coding gene Chr4:135364052-135577789 (+)
C3H/HeJ MGP_C3HHeJ_G0028686
 protein coding gene Chr4:138887781-139105180 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029413
 protein coding gene Chr4:145685397-145931623 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026684
 protein coding gene Chr4:127675045-127885488 (+)
CAST/EiJ MGP_CASTEiJ_G0028118
 protein coding gene Chr4:137044629-137267113 (+)
CBA/J MGP_CBAJ_G0028651
 protein coding gene Chr4:149841285-150078795 (+)
DBA/2J MGP_DBA2J_G0028800
 protein coding gene Chr4:135068120-135281575 (+)
FVB/NJ MGP_FVBNJ_G0028767
 protein coding gene Chr4:134090825-134305756 (+)
LP/J MGP_LPJ_G0028899
 protein coding gene Chr4:140785350-141011352 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028793
 protein coding gene Chr4:153854180-154103445 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029451
 protein coding gene Chr4:139038533-139265957 (+)
PWK/PhJ MGP_PWKPhJ_G0027838
 protein coding gene Chr4:131902231-132125756 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027664
 protein coding gene Chr4:134819460-135041876 (+)
WSB/EiJ MGP_WSBEiJ_G0028196
 protein coding gene Chr4:139256288-139495552 (+)



Homology
more
  • Human Ortholog
    EIF4G3, eukaryotic translation initiation factor 4 gamma 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EIF4G3, eukaryotic translation initiation factor 4 gamma 3
  • Synonyms
    eIF-4G 3, eIF4G 3, eIF4GII
  • Links
    NCBI Gene ID: 8672
    neXtProt AC: NX_O43432
    UniProt: O43432

  • Chr Location
    1p36.12; chr1:20806292-21177285 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 3 alleles in 5 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU induced allele exhibit decreased testes weight, azoospermia, and arrested male meiosis. Mice homozygous for a gene trapped allele exhibit small testes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    852
  • Tissues
    20
  • cDNA Data
    27
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 230861 NCBI Gene Model | MGI Sequence Detail 215308 C57BL/6J ±  kb
    transcript NM_001256195 RefSeq | MGI Sequence Detail 6241 ZRU/MplStud  
    polypeptide Q80XI3 UniProt | EBI | MGI Sequence Detail 1579 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      cDNA 28
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1926177, MGI:3512778
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 5
      Gene Ontology 7
      Phenotypes 16
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:343470 Kim SH, et al., The mRNA translation initiation factor eIF4G1 controls mitochondrial oxidative phosphorylation, axonal morphogenesis, and memory. Proc Natl Acad Sci U S A. 2023 Jun 20;120(25):e2300008120
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory