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Arfrp1 Gene Detail
Summary
  • Symbol
    Arfrp1
  • Name
    ARF related protein 1
  • Synonyms
    1500006I01Rik, MGC:6837
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923938
    NCBI Gene: 76688
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr2:180999483-181007197 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 103.63 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    161 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923938
 protein coding gene Chr2:180999483-181007197 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027020
 protein coding gene Chr2:187943611-187952258 (-)
A/J MGP_AJ_G0026986
 protein coding gene Chr2:180209463-180217470 (-)
AKR/J MGP_AKRJ_G0026957
 protein coding gene Chr2:185610396-185619847 (-)
BALB/cJ MGP_BALBcJ_G0026995
 protein coding gene Chr2:180682276-180689788 (-)
C3H/HeJ MGP_C3HHeJ_G0026736
 protein coding gene Chr2:185964927-185972420 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027441
 protein coding gene Chr2:193373738-193383493 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024805
 protein coding gene Chr2:170892328-170899751 (-)
CAST/EiJ MGP_CASTEiJ_G0026195
 protein coding gene Chr2:184224890-184232213 (-)
CBA/J MGP_CBAJ_G0026713
 protein coding gene Chr2:200381698-200391343 (-)
DBA/2J MGP_DBA2J_G0026851
 protein coding gene Chr2:179307391-179315146 (-)
FVB/NJ MGP_FVBNJ_G0026817
 protein coding gene Chr2:177925454-177932930 (-)
LP/J MGP_LPJ_G0026952
 protein coding gene Chr2:187970770-187978380 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026836
 protein coding gene Chr2:202942554-202951236 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027500
 protein coding gene Chr2:185580209-185587704 (-)
PWK/PhJ MGP_PWKPhJ_G0025931
 protein coding gene Chr2:176829586-176836974 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025731
 protein coding gene Chr2:182083395-182090889 (-)
WSB/EiJ MGP_WSBEiJ_G0026267
 protein coding gene Chr2:186567413-186574751 (-)



Homology
more
  • Human Ortholog
    ARFRP1, ARF related protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARFRP1, ARF related protein 1
  • Synonyms
    ARL18, ARP, Arp1
  • Links
    NCBI Gene ID: 10139
    neXtProt AC: NX_Q13795
    UniProt: Q13795

  • Chr Location
    20q13.33; chr20:63698642-63708025 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in embryonic lethality and abnormal development of embryonic tissues. Mutant embryos display an abnormal egg cylinder and lack the ectoplacental and exocoelomic cavities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    747
  • Tissues
    23
  • cDNA Data
    14
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 76688 NCBI Gene Model | MGI Sequence Detail 7715 C57BL/6J ±  kb
    transcript NM_001165991 RefSeq | MGI Sequence Detail 2596 C57BL/6  
    polypeptide Q8BXL7 UniProt | EBI | MGI Sequence Detail 201 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000004214 ADP-ribosylation factor-related protein 1
      (term hierarchy)
    • InterPro Domains
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
      IPR006689 Small GTPase superfamily, ARF/SAR type
      IPR024156 Small GTPase superfamily, ARF type
      IPR005225 Small GTP-binding protein domain
    Molecular
    Reagents
    less
    • All nucleic 17
      Genomic 1
      cDNA 15
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2138981
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 14
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:337689 Zhang Z, et al., Distinct changes in endosomal composition promote NLRP3 inflammasome activation. Nat Immunol. 2023 Jan;24(1):30-41
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    12/10/2024
    MGI 6.24     		The Jackson Laboratory