Clasp1 MGI Mouse Gene Detail - MGI:1923957 - CLIP associating protein 1

Symbol

Clasp1
Name

CLIP associating protein 1
Synonyms

1700030C23Rik, 5730583A19Rik, B130045P17Rik, CLASP1, CLASP1alpha, mCLASP1

Feature Type

protein coding gene
IDs

MGI:1923957
NCBI Gene: 76707
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr1:118314976-118537192 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 52.14 cM, cytoband E2
Mapping Data

3 experiments

SNPs within 2kb

4490 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1923957	protein coding gene	Chr1:118314976-118540408 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016391	protein coding gene	Chr1:121080834-121307024 (+)
A/J	MGP_AJ_G0016374	protein coding gene	Chr1:116757276-116978442 (+)
AKR/J	MGP_AKRJ_G0016339	protein coding gene	Chr1:120208775-120434408 (+)
BALB/cJ	MGP_BALBcJ_G0016334	protein coding gene	Chr1:117017199-117237129 (+)
C3H/HeJ	MGP_C3HHeJ_G0016160	protein coding gene	Chr1:120379840-120605351 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016795	protein coding gene	Chr1:125700962-125959988 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014508	protein coding gene	Chr1:110439186-110652424 (+)
CAST/EiJ	MGP_CASTEiJ_G0015741	protein coding gene	Chr1:119101638-119327784 (+)
CBA/J	MGP_CBAJ_G0016133	protein coding gene	Chr1:130072610-130313771 (+)
DBA/2J	MGP_DBA2J_G0016239	protein coding gene	Chr1:115770953-115992421 (+)
FVB/NJ	MGP_FVBNJ_G0016238	protein coding gene	Chr1:114499989-114719974 (+)
LP/J	MGP_LPJ_G0016310	protein coding gene	Chr1:122427600-122653234 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016263	protein coding gene	Chr1:135860266-136087618 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016831	protein coding gene	Chr1:119893526-120128025 (+)
PWK/PhJ	MGP_PWKPhJ_G0015527	protein coding gene	Chr1:114742505-114963879 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015315	protein coding gene	Chr1:118776675-119004904 (+)
WSB/EiJ	MGP_WSBEiJ_G0015803	protein coding gene	Chr1:119788355-120014882 (+)

Human Ortholog

CLASP1, cytoplasmic linker associated protein 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CLASP1, cytoplasmic linker associated protein 1
Synonyms

MAST1
Links

HGNC:17088

NCBI Gene ID: 23332

neXtProt AC: NX_Q7Z460

UniProt: Q7Z460
Chr Location

2q14.2-q14.3; chr2:121337776-121649476 (-) GRCh38

MGI Vertebrate Homology

Clasp1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CLASP1
Gene Tree

Clasp1

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Phenotype Summary

14 phenotypes from 1 allele in 1 genetic background
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

95
Chemically induced (other)

2
Endonuclease-mediated

1
Gene trapped

91
Radiation induced

1
Genomic Mutations

3 involving Clasp1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

163 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

68
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

710
Tissues

3
cDNA Data

213
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase clasp1

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All Sequences

216
RefSeq

100
UniProt

20

Ensembl

ENSMUSG00000064302 (Evidence)
NCBI Gene

76707

			Length	Strain/Species	Flank
genomic	76707	NCBI Gene Model \| MGI Sequence Detail	222217	C57BL/6J	± kb
transcript	NM_001293300	RefSeq \| MGI Sequence Detail	7951	C57BL/6
polypeptide	Q80TV8	UniProt \| EBI \| MGI Sequence Detail	1535	Not Applicable

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UniProt

20 Sequences
Protein Ontology

PR:000005520 CLIP-associating protein 1

(term hierarchy)
InterPro Domains

IPR011989 Armadillo-like helical

IPR016024 Armadillo-type fold

IPR024395 CLASP N-terminal domain

IPR021133 HEAT, type 2

IPR034085 TOG domain

IPR048491 XMAP215/Dis1/CLASP, TOG domain
GlyGen

Q80TV8 4 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (2 sites)

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All nucleic 216

cDNA 213

Primer pair 3

Microarray probesets 7

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MGI:1917924, MGI:2443918

Summaries

All 51

Developmental Gene Expression 5

Gene Ontology 11

Phenotypes 15
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Clasp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr8360	Chr1:118317153-118317195 (+)	2,198 bp
Tssr8361	Chr1:118317198-118317211 (+)	2,229 bp
Tssr8362	Chr1:118318954-118318960 (+)	3,981 bp
Tssr8363	Chr1:118341571-118341575 (+)	26,597 bp
Tssr8364	Chr1:118387317-118387351 (+)	72,358 bp
Tssr8365	Chr1:118397539-118397550 (+)	82,569 bp
Tssr8366	Chr1:118409178-118409187 (+)	94,207 bp
Tssr8367	Chr1:118409192-118409207 (+)	94,224 bp
Tssr8368	Chr1:118409234-118409245 (+)	94,264 bp
Tssr8369	Chr1:118409424-118409446 (+)	94,459 bp
Tssr8370	Chr1:118409696-118409709 (+)	94,727 bp
Tssr8371	Chr1:118409734-118409754 (+)	94,768 bp
Tssr8372	Chr1:118409771-118409793 (+)	94,806 bp
Tssr8373	Chr1:118409916-118409924 (+)	94,944 bp
Tssr8374	Chr1:118497634-118497638 (+)	182,660 bp
Tssr8375	Chr1:118525002-118525006 (+)	210,028 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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