Arpc2 MGI Mouse Gene Detail - MGI:1923959 - actin related protein 2/3 complex, subunit 2

Symbol

Arpc2
Name

actin related protein 2/3 complex, subunit 2
Synonyms

2210023N03Rik, p34-Arc

Feature Type

protein coding gene
IDs

MGI:1923959
NCBI Gene: 76709
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr1:74275656-74307368 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 38.49 cM, cytoband C3
Mapping Data

3 experiments

SNPs within 2kb

954 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1923959	protein coding gene	Chr1:74275243-74307368 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016143	protein coding gene	Chr1:74821391-74856161 (+)
A/J	MGP_AJ_G0016126	protein coding gene	Chr1:72202006-72235267 (+)
AKR/J	MGP_AKRJ_G0016083	protein coding gene	Chr1:74214919-74246933 (+)
BALB/cJ	MGP_BALBcJ_G0016081	protein coding gene	Chr1:72275887-72308384 (+)
C3H/HeJ	MGP_C3HHeJ_G0015912	protein coding gene	Chr1:74540136-74574629 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016534	protein coding gene	Chr1:77731682-77763634 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014255	protein coding gene	Chr1:67786419-67819326 (+)
CAST/EiJ	MGP_CASTEiJ_G0015496	protein coding gene	Chr1:73851993-73886352 (+)
CBA/J	MGP_CBAJ_G0015885	protein coding gene	Chr1:80249004-80284548 (+)
DBA/2J	MGP_DBA2J_G0015986	protein coding gene	Chr1:71540688-71572422 (+)
FVB/NJ	MGP_FVBNJ_G0015989	protein coding gene	Chr1:70713404-70746535 (+)
LP/J	MGP_LPJ_G0016058	protein coding gene	Chr1:75924543-75957322 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016009	protein coding gene	Chr1:83672583-83705546 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016581	protein coding gene	Chr1:74270021-74304629 (+)
PWK/PhJ	MGP_PWKPhJ_G0015283	protein coding gene	Chr1:70981235-71014723 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015061	protein coding gene	Chr1:73634551-73669255 (+)
WSB/EiJ	MGP_WSBEiJ_G0015558	protein coding gene	Chr1:74073734-74108327 (+)

Human Ortholog

ARPC2, actin related protein 2/3 complex subunit 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ARPC2, actin related protein 2/3 complex subunit 2
Synonyms

ARC34, p34-Arc, PNAS-139, PRO2446
Links

HGNC:705

NCBI Gene ID: 10109

neXtProt AC: NX_O15144

UniProt: O15144
Chr Location

2q35; chr2:218217141-218254356 (+) GRCh38

MGI Vertebrate Homology

Arpc2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ARPC2
Gene Tree

Arpc2

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
26 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

73
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

64
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Arpc2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

45 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

75
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

711
Tissues

2
cDNA Data

233
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase arpc2

ZFIN arpc2

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All Sequences

62
RefSeq

12
UniProt

5
CCDS

CCDS35612.1

Ensembl

ENSMUSG00000006304 (Evidence)
NCBI Gene

76709

			Length	Strain/Species	Flank
genomic	76709	NCBI Gene Model \| MGI Sequence Detail	31713	C57BL/6J	± kb
transcript	NM_029711	RefSeq \| MGI Sequence Detail	1599	C57BL/6
polypeptide	Q9CVB6	UniProt \| EBI \| MGI Sequence Detail	300	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000004310 actin-related protein 2/3 complex subunit 2

(term hierarchy)
PDB

7AQK
InterPro Domains

IPR007188 Actin-related protein 2/3 complex subunit 2

IPR034666 Arp2/3 complex subunit 2/4
GlyGen

Q9CVB6 1 site, 1 O-linked glycan (1 site)

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All nucleic 234

cDNA 234

Microarray probesets 3

Summaries

All 66

Developmental Gene Expression 3

Gene Ontology 13

Phenotypes 26
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Arpc2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr7361	Chr1:74275638-74275757 (+)	42 bp
Tssr7362	Chr1:74275761-74275787 (+)	118 bp
Tssr7363	Chr1:74277451-74277479 (+)	1,809 bp
Tssr7364	Chr1:74285145-74285148 (+)	9,491 bp
Tssr120	Chr1:74288280-74288291 (+)	12,630 bp
Tssr7365	Chr1:74299175-74299179 (+)	23,521 bp
Tssr7366	Chr1:74300279-74300295 (+)	24,631 bp
Tssr7367	Chr1:74302892-74302953 (+)	27,267 bp
Tssr7368	Chr1:74306926-74306953 (+)	31,284 bp
Tssr7369	Chr1:74306965-74307008 (+)	31,331 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24