Snx27 MGI Mouse Gene Detail - MGI:1923992 - sorting nexin family member 27

Symbol

Snx27
Name

sorting nexin family member 27
Synonyms

5730552M22Rik, ESTM47, mKIAA0488

Feature Type

protein coding gene
IDs

MGI:1923992
NCBI Gene: 76742
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr3:94404851-94490023 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 40.74 cM, cytoband F2
Mapping Data

3 experiments

SNPs within 2kb

1487 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1923992	protein coding gene	Chr3:94404849-94490023 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0027554	protein coding gene	Chr3:95076515-95162376 (-)
A/J	MGP_AJ_G0027513	protein coding gene	Chr3:92185133-92264781 (-)
AKR/J	MGP_AKRJ_G0027481	protein coding gene	Chr3:94280090-94362673 (-)
BALB/cJ	MGP_BALBcJ_G0027524	protein coding gene	Chr3:91894937-91974055 (-)
C3H/HeJ	MGP_C3HHeJ_G0027260	protein coding gene	Chr3:94585048-94667574 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0027973	protein coding gene	Chr3:98662563-98757159 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025315	protein coding gene	Chr3:88675597-88756302 (-)
CAST/EiJ	MGP_CASTEiJ_G0026708	protein coding gene	Chr3:93922432-94007406 (-)
CBA/J	MGP_CBAJ_G0027236	protein coding gene	Chr3:102163430-102250576 (-)
DBA/2J	MGP_DBA2J_G0027375	protein coding gene	Chr3:91448976-91527728 (-)
FVB/NJ	MGP_FVBNJ_G0027345	protein coding gene	Chr3:89547356-89624922 (-)
LP/J	MGP_LPJ_G0027483	protein coding gene	Chr3:96384384-96466218 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027372	protein coding gene	Chr3:108394457-108477787 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028027	protein coding gene	Chr3:93955402-94042695 (-)
PWK/PhJ	MGP_PWKPhJ_G0026436	protein coding gene	Chr3:91337793-91418094 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0026257	protein coding gene	Chr3:92298784-92373469 (-)
WSB/EiJ	MGP_WSBEiJ_G0026791	protein coding gene	Chr3:94309193-94394597 (-)

Human Ortholog

SNX27, sorting nexin 27

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SNX27, sorting nexin 27
Synonyms

MRT1, MY014
Links

HGNC:20073

NCBI Gene ID: 81609

neXtProt AC: NX_Q96L92

UniProt: Q96L92
Chr Location

1q21.3; chr1:151612006-151699091 (+) GRCh38

MGI Vertebrate Homology

Snx27 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: SNX27
Gene Tree

Snx27

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References

1 with disease annotations

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Phenotype Summary

15 phenotypes from 2 alleles in 3 genetic backgrounds
26 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

5
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Snx27
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

25 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit prenatal and postnatal lethality, decreased organ size, slow postnatal weight gain, and decreased endocytosis of Grin2c.

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All GO Annotations

54
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

808
Tissues

40
cDNA Data

14
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase snx27

ZFIN snx27a, snx27b

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All Sequences

66
RefSeq

10
UniProt

5
CCDS

CCDS38537.1, CCDS38538.1

Ensembl

ENSMUSG00000028136 (Evidence)
NCBI Gene

76742

			Length	Strain/Species	Flank
genomic	ENSMUSG00000028136	Ensembl Gene Model \| MGI Sequence Detail	85173	C57BL/6J	± kb
transcript	ENSMUST00000107283	Ensembl \| MGI Sequence Detail	3531	Not Applicable
polypeptide	ENSMUSP00000102904	Ensembl \| MGI Sequence Detail	539	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000015376 sorting nexin-27

(term hierarchy)
InterPro Domains

IPR001478 PDZ domain

IPR036034 PDZ superfamily

IPR001683 Phox homology

IPR036871 PX domain superfamily

IPR000159 Ras-associating domain

IPR037831 SNX17/27/31-like

IPR037827 SNX27, atypical FERM-like domain

IPR037833 SNX27, PX domain

IPR037835 SNX27, RA domain

IPR029071 Ubiquitin-like domain superfamily
GlyGen

Q3UHD6 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 16

cDNA 14

Primer pair 1

Other 1

Microarray probesets 6

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MGI:1334427

Summaries

All 64

Developmental Gene Expression 1

Diseases 1

Gene Ontology 12

Phenotypes 26
Earliest

J:52606 Eddleston J, et al., Physical and transcriptional map of a 3-Mb region of mouse chromosome 1 containing the gene for the neural tube defect mutant loop-tail (Lp). Genomics. 1999 Mar 1;56(2):149-59
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Snx27:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr34399	Chr3:94490066-94490077 (-)	-49 bp
Tssr34398	Chr3:94490027-94490048 (-)	-15 bp
Tssr34397	Chr3:94489994-94490015 (-)	18 bp
Tssr34396	Chr3:94489971-94489983 (-)	46 bp
Tssr34395	Chr3:94489855-94489880 (-)	155 bp
Tssr34394	Chr3:94487434-94487446 (-)	2,583 bp
Tssr34393	Chr3:94479913-94479939 (-)	10,097 bp
Tssr34392	Chr3:94408578-94408588 (-)	81,440 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24