Mlec MGI Mouse Gene Detail - MGI:1924015

Symbol

Mlec
Name

malectin
Synonyms

2410014A08Rik, ESTM19, mKIAA0152

Feature Type

protein coding gene
IDs

MGI:1924015
NCBI Gene: 109154
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr5:115281040-115296235 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 55.99 cM
Mapping Data

3 experiments

SNPs within 2kb

333 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1924015	protein coding gene	Chr5:115281040-115296238 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0029959	protein coding gene	Chr5:117978583-117995598 (-)
A/J	MGP_AJ_G0029924	protein coding gene	Chr5:113305364-113320457 (-)
AKR/J	MGP_AKRJ_G0029862	protein coding gene	Chr5:116915667-116933964 (-)
BALB/cJ	MGP_BALBcJ_G0029935	protein coding gene	Chr5:114704398-114719558 (-)
C3H/HeJ	MGP_C3HHeJ_G0029654	protein coding gene	Chr5:117438486-117453629 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0030389	protein coding gene	Chr5:122528699-122543817 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027616	protein coding gene	Chr5:108081030-108096017 (-)
CAST/EiJ	MGP_CASTEiJ_G0029063	protein coding gene	Chr5:116356173-116371185 (-)
CBA/J	MGP_CBAJ_G0029622	protein coding gene	Chr5:127225317-127240426 (-)
DBA/2J	MGP_DBA2J_G0029772	protein coding gene	Chr5:113375490-113390964 (-)
FVB/NJ	MGP_FVBNJ_G0029728	protein coding gene	Chr5:112189911-112205206 (-)
LP/J	MGP_LPJ_G0029860	protein coding gene	Chr5:118549347-118564505 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029759	protein coding gene	Chr5:131565052-131582509 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030430	protein coding gene	Chr5:116393465-116410116 (-)
PWK/PhJ	MGP_PWKPhJ_G0028776	protein coding gene	Chr5:112038368-112052456 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0028614	protein coding gene	Chr5:113943928-113958918 (-)
WSB/EiJ	MGP_WSBEiJ_G0029138	protein coding gene	Chr5:116981341-116996439 (-)

Human Ortholog

MLEC, malectin

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MLEC, malectin
Synonyms

KIAA0152
Links

HGNC:28973

NCBI Gene ID: 9761

neXtProt AC: NX_Q14165

UniProt: Q14165
Chr Location

12q24.31; chr12:120687149-120701859 (+) GRCh38

MGI Vertebrate Homology

Mlec stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MLEC
Gene Tree

Mlec

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

34
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

28
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Mlec
Incidental Mutations

CvDC
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

10
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

770
Tissues

9
cDNA Data

15
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mlec

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All Sequences

49
RefSeq

6
UniProt

1
CCDS

CCDS19581.1

Ensembl

ENSMUSG00000048578 (Evidence)
NCBI Gene

109154

			Length	Strain/Species	Flank
genomic	109154	NCBI Gene Model \| MGI Sequence Detail	15196	C57BL/6J	± kb
transcript	NM_175403	RefSeq \| MGI Sequence Detail	5970	ZRU/MplStud
polypeptide	Q6ZQI3	UniProt \| EBI \| MGI Sequence Detail	291	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000010438 malectin

(term hierarchy)
InterPro Domains

IPR039155 Malectin

IPR021720 Malectin domain
GlyGen

Q6ZQI3 2 sites, 1 O-linked glycan (1 site)

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All nucleic 16

cDNA 15

Primer pair 1

Microarray probesets 7

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MGD-MRK-28124, MGI:104830, MGI:2140989

Summaries

All 47

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 18
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Mlec:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr52765	Chr5:115296424-115296449 (-)	-202 bp
Tssr52764	Chr5:115296395-115296406 (-)	-166 bp
Tssr52763	Chr5:115296228-115296239 (-)	1 bp
Tssr52762	Chr5:115296194-115296218 (-)	29 bp
Tssr52761	Chr5:115294986-115294991 (-)	1,246 bp
Tssr52760	Chr5:115293234-115293262 (-)	2,987 bp
Tssr52759	Chr5:115290429-115290440 (-)	5,800 bp
Tssr52758	Chr5:115286114-115286133 (-)	10,111 bp
Tssr52757	Chr5:115286065-115286098 (-)	10,153 bp
Tssr52756	Chr5:115285900-115285946 (-)	10,312 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24