Klhdc10 MGI Mouse Gene Detail - MGI:1924038 - kelch domain containing 10

Symbol

Klhdc10
Name

kelch domain containing 10
Synonyms

2410127E18Rik

Feature Type

protein coding gene
IDs

MGI:1924038
NCBI Gene: 76788
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr6:30401867-30455178 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 12.52 cM, cytoband A3
Mapping Data

3 experiments

SNPs within 2kb

1234 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1924038	protein coding gene	Chr6:30401516-30455178 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030536	protein coding gene	Chr6:28282023-28342202 (+)
A/J	MGP_AJ_G0030509	protein coding gene	Chr6:27068652-27122721 (+)
AKR/J	MGP_AKRJ_G0030436	protein coding gene	Chr6:27968785-28026319 (+)
BALB/cJ	MGP_BALBcJ_G0030519	protein coding gene	Chr6:27219397-27273259 (+)
C3H/HeJ	MGP_C3HHeJ_G0030232	protein coding gene	Chr6:27962588-28022444 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030973	protein coding gene	Chr6:29088020-29145374 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028184	protein coding gene	Chr6:25263101-25318586 (+)
CAST/EiJ	MGP_CASTEiJ_G0029634	protein coding gene	Chr6:27787615-27843814 (+)
CBA/J	MGP_CBAJ_G0030210	protein coding gene	Chr6:30186221-30251229 (+)
DBA/2J	MGP_DBA2J_G0030354	protein coding gene	Chr6:26997526-27051047 (+)
FVB/NJ	MGP_FVBNJ_G0030308	protein coding gene	Chr6:26761860-26817707 (+)
LP/J	MGP_LPJ_G0030441	protein coding gene	Chr6:28419283-28478083 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030344	protein coding gene	Chr6:32642462-32699618 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031003	protein coding gene	Chr6:27850410-27904122 (+)
PWK/PhJ	MGP_PWKPhJ_G0029348	protein coding gene	Chr6:26571850-26626051 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029184	protein coding gene	Chr6:27586213-27645932 (+)
WSB/EiJ	MGP_WSBEiJ_G0029710	protein coding gene	Chr6:27819362-27873019 (+)

Human Ortholog

KLHDC10, kelch domain containing 10

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KLHDC10, kelch domain containing 10
Synonyms

PNAS-138, slim
Links

HGNC:22194

NCBI Gene ID: 23008

neXtProt AC: NX_Q6PID8

UniProt: Q6PID8, Q9BZS9
Chr Location

7q32.2; chr7:130070534-130135705 (+) GRCh38

MGI Vertebrate Homology

Klhdc10 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: KLHDC10
Gene Tree

Klhdc10

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Phenotype Summary

8 phenotypes from 2 alleles in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

2
Gene trapped

6
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

32 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele are resistant to TNF-induced lethality and hyporthemia and show a decreased inflammatory response with reduced IL-6 production in spleen and reduced serum IL-6 levels after TNF injection.

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All GO Annotations

14
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

16

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase klhdc10

ZFIN klhdc10

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All Sequences

70
RefSeq

8
UniProt

4
CCDS

CCDS19971.1, CCDS80509.1

Ensembl

ENSMUSG00000029775 (Evidence)
NCBI Gene

76788

			Length	Strain/Species	Flank
genomic	ENSMUSG00000029775	Ensembl Gene Model \| MGI Sequence Detail	53312	C57BL/6J	± kb
transcript	ENSMUST00000068259	Ensembl \| MGI Sequence Detail	5901	Not Applicable
polypeptide	ENSMUSP00000069669	Ensembl \| MGI Sequence Detail	439	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000031222 kelch domain-containing protein 10

(term hierarchy)
InterPro Domains

IPR052125 Kelch domain-containing protein 10

IPR006652 Kelch repeat type 1

IPR015915 Kelch-type beta propeller

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All nucleic 16

cDNA 16

Microarray probesets 6

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MGI:2141451

Summaries

All 37

Gene Ontology 6

Phenotypes 11
Earliest

J:61896 Lee YJ, et al., Mit1/Lb9 and Copg2, new members of mouse imprinted genes closely linked to Peg1/Mest(1). FEBS Lett. 2000 Apr 28;472(2-3):230-4
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Klhdc10:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr55338	Chr6:30401865-30401964 (+)	48 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24