Hyls1 MGI Mouse Gene Detail - MGI:1924082 - HYLS1, centriolar and ciliogenesis associated

Symbol

Hyls1
Name

HYLS1, centriolar and ciliogenesis associated
Synonyms

3010015K02Rik, hydrolethalus syndrome 1

Feature Type

protein coding gene
IDs

MGI:1924082
NCBI Gene: 76832
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr9:35472117-35481365 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 20.32 cM
Mapping Data

1 experiment

SNPs within 2kb

247 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1924082	protein coding gene	Chr9:35472116-35481694 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0034538	protein coding gene	Chr9:33376230-33385807 (-)
A/J	MGP_AJ_G0034516	protein coding gene	Chr9:32506815-32516398 (-)
AKR/J	MGP_AKRJ_G0034442	protein coding gene	Chr9:33241363-33250951 (-)
BALB/cJ	MGP_BALBcJ_G0034507	protein coding gene	Chr9:32425144-32434721 (-)
C3H/HeJ	MGP_C3HHeJ_G0034219	protein coding gene	Chr9:33574651-33584225 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0035028	protein coding gene	Chr9:34490274-34499849 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031958	protein coding gene	Chr9:31194433-31204135 (-)
CAST/EiJ	MGP_CASTEiJ_G0033542	protein coding gene	Chr9:33480626-33490241 (-)
CBA/J	MGP_CBAJ_G0034193	protein coding gene	Chr9:35646776-35656365 (-)
DBA/2J	MGP_DBA2J_G0034350	protein coding gene	Chr9:32490461-32500095 (-)
FVB/NJ	MGP_FVBNJ_G0034293	protein coding gene	Chr9:31907652-31917238 (-)
LP/J	MGP_LPJ_G0034436	protein coding gene	Chr9:33618653-33628246 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034337	protein coding gene	Chr9:37210659-37221164 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035048	protein coding gene	Chr9:33188450-33198055 (-)
PWK/PhJ	MGP_PWKPhJ_G0033247	protein coding gene	Chr9:32475562-32485148 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0033082	protein coding gene	Chr9:33338649-33348255 (-)
WSB/EiJ	MGP_WSBEiJ_G0033657	protein coding gene	Chr9:32962054-32971630 (-)

Human Ortholog

HYLS1, HYLS1 centriolar and ciliogenesis associated

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HYLS1, HYLS1 centriolar and ciliogenesis associated
Synonyms

HLS
Links

HGNC:26558

NCBI Gene ID: 219844

neXtProt AC: NX_Q96M11

UniProt: Q96M11
Chr Location

11q24.2; chr11:125883614-125900646 (+) GRCh38

MGI Vertebrate Homology

Hyls1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HYLS1
Gene Tree

Hyls1

Diseases

1 with human HYLS1 associations

				Human Disease	Mouse Models
				hydrolethalus syndrome 1 IDs hydrolethalus syndrome 1 DOID:0111355 MESH:C565504 OMIM:236680

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

10 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Endonuclease-mediated

2
Gene trapped

7
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

29 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

11
GO References

5

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

757
Tissues

42
cDNA Data

7
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

32
RefSeq

2
UniProt

2
CCDS

CCDS52754.1

Ensembl

ENSMUSG00000050555 (Evidence)
NCBI Gene

76832

			Length	Strain/Species	Flank
genomic	76832	NCBI Gene Model \| MGI Sequence Detail	9249	C57BL/6J	± kb
transcript	NM_029762	RefSeq \| MGI Sequence Detail	1643	C57BL/6
polypeptide	Q9CXX0	UniProt \| EBI \| MGI Sequence Detail	307	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000008852 centriolar and ciliogenesis-associated protein HYLS1

(term hierarchy)
InterPro Domains

IPR052319 Centriolar and ciliogenesis-associated protein

IPR026227 Centriolar and ciliogenesis-associated protein HYLS1

IPR027918 Centriolar and ciliogenesis-associated protein HYLS1, C-terminal domain

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All nucleic 10

cDNA 8

Primer pair 2

Microarray probesets 2

Summaries

All 32

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 10
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Hyls1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr88753	Chr9:35481771-35481772 (-)	-407 bp
Tssr88752	Chr9:35481739-35481746 (-)	-378 bp
Tssr88751	Chr9:35481718-35481736 (-)	-362 bp
Tssr88750	Chr9:35481699-35481716 (-)	-343 bp
Tssr88749	Chr9:35481689-35481698 (-)	-329 bp
Tssr88748	Chr9:35481384-35481417 (-)	-36 bp
Tssr88747	Chr9:35481315-35481369 (-)	23 bp
Tssr88746	Chr9:35481047-35481057 (-)	313 bp
Tssr88745	Chr9:35481036-35481044 (-)	325 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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