Bcas1 MGI Mouse Gene Detail - MGI:1924210 - brain enriched myelin associated protein 1

Symbol

Bcas1
Name

brain enriched myelin associated protein 1
Synonyms

2210416M21Rik, 9030223A09Rik, breast carcinoma amplified sequence 1, NABC1

Feature Type

protein coding gene
IDs

MGI:1924210
NCBI Gene: 76960
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr2:170188911-170269765 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 91.41 cM
Mapping Data

2 experiments

SNPs within 2kb

2997 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1924210	protein coding gene	Chr2:170188911-170270292 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0026934	protein coding gene	Chr2:176389616-176475368 (-)
A/J	MGP_AJ_G0026901	protein coding gene	Chr2:169020687-169102782 (-)
AKR/J	MGP_AKRJ_G0026872	protein coding gene	Chr2:174084721-174166840 (-)
BALB/cJ	MGP_BALBcJ_G0026910	protein coding gene	Chr2:169397169-169479623 (-)
C3H/HeJ	MGP_C3HHeJ_G0026652	protein coding gene	Chr2:174457035-174538249 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0027357	protein coding gene	Chr2:181476437-181568781 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024727	protein coding gene	Chr2:162318979-162399124 (-)
CAST/EiJ	MGP_CASTEiJ_G0026110	protein coding gene	Chr2:175042696-175137985 (-)
CBA/J	MGP_CBAJ_G0026629	protein coding gene	Chr2:188247763-188340166 (-)
DBA/2J	MGP_DBA2J_G0026767	protein coding gene	Chr2:168115040-168196881 (-)
FVB/NJ	MGP_FVBNJ_G0026733	protein coding gene	Chr2:166713106-166794774 (-)
LP/J	MGP_LPJ_G0026868	protein coding gene	Chr2:176340578-176420656 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026752	protein coding gene	Chr2:191350180-191440985 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027414	protein coding gene	Chr2:174040678-174125552 (-)
PWK/PhJ	MGP_PWKPhJ_G0025847	protein coding gene	Chr2:167839542-167924488 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0025647	protein coding gene	Chr2:173031300-173127810 (-)
WSB/EiJ	MGP_WSBEiJ_G0026183	protein coding gene	Chr2:174989916-175081639 (-)

Human Ortholog

BCAS1, brain enriched myelin associated protein 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BCAS1, brain enriched myelin associated protein 1
Synonyms

AIBC1, NABC1, PMES-2
Links

HGNC:974

NCBI Gene ID: 8537

neXtProt AC: NX_O75363

UniProt: O75363
Chr Location

20q13.2; chr20:53936777-54070594 (-) GRCh38

MGI Vertebrate Homology

Bcas1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: BCAS1
Gene Tree

Bcas1

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Phenotype Summary

8 phenotypes from 2 alleles in 2 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Endonuclease-mediated

4
Gene trapped

4
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

40 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit hypomyelination, decreased prepulse inhibition suggestive of schizophrenia-like symptoms, a tendency toward reduced anxiety-like behaviors, and upregulation of inflammation-related genes in the brain.

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All GO Annotations

7
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

27
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

84
RefSeq

30
UniProt

8
CCDS

CCDS17121.1, CCDS50806.1

Ensembl

ENSMUSG00000013523 (Evidence)
NCBI Gene

76960

			Length	Strain/Species	Flank
genomic	ENSMUSG00000013523	Ensembl Gene Model \| MGI Sequence Detail	80855	C57BL/6J	± kb
transcript	ENSMUST00000013667	Ensembl \| MGI Sequence Detail	2916	Not Applicable
polypeptide	ENSMUSP00000013667	Ensembl \| MGI Sequence Detail	633	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000004678 breast carcinoma-amplified sequence 1

(term hierarchy)
InterPro Domains

IPR026115 Novel Amplified in Breast Cancer-1
GlyGen

Q80YN3 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 29

Genomic 2

cDNA 27

Microarray probesets 5

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MGI:1924916, MGI:2139067

Summaries

All 38

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 12
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Bcas1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr27926	Chr2:170269773-170269782 (-)	-13 bp
Tssr27925	Chr2:170269757-170269772 (-)	0 bp
Tssr27924	Chr2:170248421-170248438 (-)	21,335 bp
Tssr27923	Chr2:170229891-170229937 (-)	39,851 bp
Tssr27922	Chr2:170229860-170229889 (-)	39,890 bp
Tssr27921	Chr2:170199042-170199049 (-)	70,719 bp
Tssr27920	Chr2:170199026-170199040 (-)	70,732 bp
Tssr27919	Chr2:170191161-170191163 (-)	78,603 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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