Slc9a8 MGI Mouse Gene Detail - MGI:1924281 - solute carrier family 9 (sodium/hydrogen exchanger), member 8

Symbol

Slc9a8
Name

solute carrier family 9 (sodium/hydrogen exchanger), member 8
Synonyms

1200006P13Rik, 6430709P13Rik, NHE8

Feature Type

protein coding gene
IDs

MGI:1924281
NCBI Gene: 77031
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr2:167263632-167318920 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 87.22 cM
Mapping Data

2 experiments

SNPs within 2kb

1268 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1924281	protein coding gene	Chr2:167261678-167318920 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026912	protein coding gene	Chr2:173150247-173213353 (+)
A/J	MGP_AJ_G0026879	protein coding gene	Chr2:166027391-166083233 (+)
AKR/J	MGP_AKRJ_G0026850	protein coding gene	Chr2:170977582-171035877 (+)
BALB/cJ	MGP_BALBcJ_G0026888	protein coding gene	Chr2:166381361-166439219 (+)
C3H/HeJ	MGP_C3HHeJ_G0026630	protein coding gene	Chr2:171345703-171404660 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027335	protein coding gene	Chr2:178196319-178271366 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024706	protein coding gene	Chr2:159343342-159399565 (+)
CAST/EiJ	MGP_CASTEiJ_G0026088	protein coding gene	Chr2:171808132-171869069 (+)
CBA/J	MGP_CBAJ_G0026607	protein coding gene	Chr2:184729054-184805982 (+)
DBA/2J	MGP_DBA2J_G0026745	protein coding gene	Chr2:165141366-165196109 (+)
FVB/NJ	MGP_FVBNJ_G0026711	protein coding gene	Chr2:163662286-163722256 (+)
LP/J	MGP_LPJ_G0026846	protein coding gene	Chr2:173168954-173230060 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026730	protein coding gene	Chr2:188122688-188189986 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027392	protein coding gene	Chr2:170904623-170967476 (+)
PWK/PhJ	MGP_PWKPhJ_G0025825	protein coding gene	Chr2:164800462-164860025 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025626	protein coding gene	Chr2:169844354-169906019 (+)
WSB/EiJ	MGP_WSBEiJ_G0026161	protein coding gene	Chr2:171814292-171873900 (+)

Human Ortholog

SLC9A8, solute carrier family 9 member A8

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC9A8, solute carrier family 9 member A8
Synonyms

NHE-8, NHE8
Links

HGNC:20728

NCBI Gene ID: 23315

neXtProt AC: NX_Q9Y2E8

UniProt: Q9Y2E8
Chr Location

20q13.13; chr20:49812713-49892242 (+) GRCh38

MGI Vertebrate Homology

Slc9a8 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SLC9A8
Gene Tree

Slc9a8

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Phenotype Summary

22 phenotypes from 5 alleles in 6 genetic backgrounds
25 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

133
Chemically induced (ENU)

2
Gene trapped

125
Targeted

6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

108 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a null allele show male sterility, impaired mucin synthesis and bicarbonate secretion in the colon and elongation of the small intestine, cecum and ileum crypts. Homozygotes for another null allele show male sterility, asthenospermia, globozoospermia, and abnormal acrosome assembly.

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All GO Annotations

40
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

827
Tissues

121
cDNA Data

86
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc9a8

ZFIN slc9a8

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All Sequences

88
RefSeq

30
UniProt

3
CCDS

CCDS38339.1, CCDS38340.1, CCDS84586.1

Ensembl

ENSMUSG00000039463 (Evidence)
NCBI Gene

77031

			Length	Strain/Species	Flank
genomic	ENSMUSG00000039463	Ensembl Gene Model \| MGI Sequence Detail	55289	C57BL/6J	± kb
transcript	ENSMUST00000047815	Ensembl \| MGI Sequence Detail	4521	Not Applicable
polypeptide	ENSMUSP00000044185	Ensembl \| MGI Sequence Detail	576	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000015220 sodium/hydrogen exchanger 8

(term hierarchy)
InterPro Domains

IPR006153 Cation/H+ exchanger

IPR018422 Cation/H+ exchanger, CPA1 family

IPR004709 Na+/H+ exchanger
GlyGen

Q8R4D1 2 sites, 1 N-linked glycan (2 sites)

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All nucleic 87

cDNA 86

Primer pair 1

Microarray probesets 6

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MGI:1923489, MGI:2138851

Summaries

All 62

Developmental Gene Expression 2

Gene Ontology 11

Phenotypes 25
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Slc9a8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr21807	Chr2:167263612-167263623 (+)	-14 bp
Tssr21808	Chr2:167263626-167263652 (+)	7 bp
Tssr21809	Chr2:167263957-167263970 (+)	332 bp
Tssr21810	Chr2:167285683-167285688 (+)	22,054 bp
Tssr21811	Chr2:167292931-167292950 (+)	29,309 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24