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Sun1 Gene Detail
Summary
  • Symbol
    Sun1
  • Name
    Sad1 and UNC84 domain containing 1
  • Synonyms
    4632417G13Rik, 5730434D03Rik, mKIAA0810, Unc84a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924303
    NCBI Gene: 77053
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:139186392-139235595 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 78.12 cM, cytoband G1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1180 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924303
 protein coding gene Chr5:139186313-139235595 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030277
 protein coding gene Chr5:144154507-144206696 (+)
A/J MGP_AJ_G0030246
 protein coding gene Chr5:138053655-138101975 (+)
AKR/J MGP_AKRJ_G0030178
 protein coding gene Chr5:142357558-142406123 (+)
BALB/cJ MGP_BALBcJ_G0030263
 protein coding gene Chr5:139299990-139349825 (+)
C3H/HeJ MGP_C3HHeJ_G0029974
 protein coding gene Chr5:143127355-143179556 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030708
 protein coding gene Chr5:149472783-149526800 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027926
 protein coding gene Chr5:131915397-131962707 (+)
CAST/EiJ MGP_CASTEiJ_G0029379
 protein coding gene Chr5:142539274-142588927 (+)
CBA/J MGP_CBAJ_G0029944
 protein coding gene Chr5:155642686-155694053 (+)
DBA/2J MGP_DBA2J_G0030094
 protein coding gene Chr5:137869494-137916565 (+)
FVB/NJ MGP_FVBNJ_G0030049
 protein coding gene Chr5:136967251-137016978 (+)
LP/J MGP_LPJ_G0030180
 protein coding gene Chr5:144777979-144828141 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030080
 protein coding gene Chr5:158326177-158379978 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030748
 protein coding gene Chr5:142164615-142215186 (+)
PWK/PhJ MGP_PWKPhJ_G0029094
 protein coding gene Chr5:136863244-136910734 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028930
 protein coding gene Chr5:139852002-139899917 (+)
WSB/EiJ MGP_WSBEiJ_G0029453
 protein coding gene Chr5:142928798-142979885 (+)



Homology
more
  • Human Ortholog
    SUN1, Sad1 and UNC84 domain containing 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SUN1, Sad1 and UNC84 domain containing 1
  • Synonyms
    UNC84A
  • Links
    NCBI Gene ID: 23353
    neXtProt AC: NX_O94901
    UniProt: O94901

  • Chr Location
    7p22.3; chr7:815557-896435 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    53 phenotypes from 5 alleles in 9 genetic backgrounds
    24 phenotypes from multigenic genotypes
    151 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit sterility due to arrested meiosis, hearing loss associated with outer hair cell degeneration, abnormal cerebellum development, ataxia, impaired motor coordination, and abnormal Purkinje cell migration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    714
  • Tissues
    4
  • cDNA Data
    191
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000036817 Ensembl Gene Model | MGI Sequence Detail 49204 C57BL/6J ±  kb
    transcript ENSMUST00000058716 Ensembl | MGI Sequence Detail 4134 Not Applicable  
    polypeptide ENSMUSP00000056655 Ensembl | MGI Sequence Detail 913 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 191
      cDNA 191

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1922034
    References
    more
    • Summaries
      All 202
      Developmental Gene Expression 12
      Gene Ontology 20
      Phenotypes 151
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:357933 Kim B, et al., PCLAF-DREAM drives alveolar cell plasticity for lung regeneration. Nat Commun. 2024 Oct 24;15(1):9169
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory