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Ankrd11 Gene Detail
Summary
  • Symbol
    Ankrd11
  • Name
    ankyrin repeat domain 11
  • Synonyms
    2410104C19Rik, 3010027A04Rik, 9530048I21Rik, Yod
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924337
    NCBI Gene: 77087
  • Alliance
    gene page
  • Transcription Start Sites
    34 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:123610561-123769016 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 72.00 cM, cytoband E2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3514 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924337
 protein coding gene Chr8:123610060-123769023 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034239
 protein coding gene Chr8:126453608-126551682 (-)
A/J MGP_AJ_G0034219
 protein coding gene Chr8:121223097-121317700 (-)
AKR/J MGP_AKRJ_G0034146
 protein coding gene Chr8:124761515-124855045 (-)
BALB/cJ MGP_BALBcJ_G0034213
 protein coding gene Chr8:121416085-121509348 (-)
C3H/HeJ MGP_C3HHeJ_G0033923
 protein coding gene Chr8:125452779-125547602 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034732
 protein coding gene Chr8:130691849-130789904 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031674
 protein coding gene Chr8:114042783-114132280 (-)
CAST/EiJ MGP_CASTEiJ_G0033251
 protein coding gene Chr8:125537221-125631977 (-)
CBA/J MGP_CBAJ_G0033896
 protein coding gene Chr8:135484845-135580958 (-)
DBA/2J MGP_DBA2J_G0034053
 protein coding gene Chr8:120405462-120497643 (-)
FVB/NJ MGP_FVBNJ_G0033996
 protein coding gene Chr8:119556397-119647939 (-)
LP/J MGP_LPJ_G0034142
 protein coding gene Chr8:126580985-126681958 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034043
 protein coding gene Chr8:137623504-137716138 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034751
 protein coding gene Chr8:124932548-125028263 (-)
PWK/PhJ MGP_PWKPhJ_G0032952
 protein coding gene Chr8:120228642-120323604 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032792
 protein coding gene Chr8:123655656-123750270 (-)
WSB/EiJ MGP_WSBEiJ_G0033367
 protein coding gene Chr8:125690919-125783671 (-)



Homology
more
  • Human Ortholog
    ANKRD11, ankyrin repeat domain containing 11
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ANKRD11, ankyrin repeat domain containing 11
  • Synonyms
    ANCO-1, ANCO1, LZ16, T13
  • Links
    NCBI Gene ID: 29123
    neXtProt AC: NX_Q6UB99
    UniProt: Q6UB99

  • Chr Location
    16q24.3; chr16:89267619-89490561 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ankrd11 mouse models; 1 with human ANKRD11 associations

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    79 phenotypes from 3 alleles in 3 genetic backgrounds
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a spontaneous allele die by E9.5, are small and fail to turn. Mice heterozygous for a spontaneous allele exhibit craniofacial abnormalities, decreased weight, osteoporosis and osteopenia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    765
  • Tissues
    43
  • cDNA Data
    272
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035569 Ensembl Gene Model | MGI Sequence Detail 158456 C57BL/6J ±  kb
    transcript ENSMUST00000098333 Ensembl | MGI Sequence Detail 7995 Not Applicable  
    polypeptide ENSMUSP00000095938 Ensembl | MGI Sequence Detail 2664 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      13 Sequences
    • Protein Ontology
      PR:000004041 ankyrin repeat domain-containing protein 11
      (term hierarchy)
    • InterPro Domains
      IPR002110 Ankyrin repeat
      IPR036770 Ankyrin repeat-containing domain superfamily
      IPR042636 Ankyrin repeat domain-containing protein 11
    • GlyGen
      E9Q4F7 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 273
      cDNA 272
      Primer pair 1

      Microarray probesets 12
    Other
    Accession IDs
    less
    MGI:1890436, MGI:1924033, MGI:1925914, MGI:2142446, MGI:2685022
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 8
      Phenotypes 24
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:359520 Goodkey K, et al., Olfactory bulb anomalies in KBG syndrome mouse model and patients. BMC Med. 2024 Apr 15;22(1):158
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory