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Pacs2 Gene Detail
Summary
  • Symbol
    Pacs2
  • Name
    phosphofurin acidic cluster sorting protein 2
  • Synonyms
    6720425G15Rik, mKIAA0602, Pacs1l
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924399
    NCBI Gene: 217893
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:112978128-113038021 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 61.57 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1370 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924399
 protein coding gene Chr12:112977998-113038021 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020169
 protein coding gene Chr12:115502618-115565923 (+)
A/J MGP_AJ_G0020125
 protein coding gene Chr12:111033254-111093431 (+)
AKR/J MGP_AKRJ_G0020100
 protein coding gene Chr12:114261962-114321507 (+)
BALB/cJ MGP_BALBcJ_G0020110
 protein coding gene Chr12:111498072-111558420 (+)
C3H/HeJ MGP_C3HHeJ_G0019912
 protein coding gene Chr12:114781924-114840933 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020555
 protein coding gene Chr12:119049593-119116034 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018169
 protein coding gene Chr12:107470067-107529419 (+)
CAST/EiJ MGP_CASTEiJ_G0019452
 protein coding gene Chr12:109620012-109681656 (+)
CBA/J MGP_CBAJ_G0019879
 protein coding gene Chr12:123616981-123677404 (+)
DBA/2J MGP_DBA2J_G0019996
 protein coding gene Chr12:110533593-110593604 (+)
FVB/NJ MGP_FVBNJ_G0019981
 protein coding gene Chr12:109365531-109432124 (+)
LP/J MGP_LPJ_G0020070
 protein coding gene Chr12:115323509-115384752 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020019
 protein coding gene Chr12:126702536-126768676 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020584
 protein coding gene Chr12:113772377-113835735 (+)
PWK/PhJ MGP_PWKPhJ_G0019214
 protein coding gene Chr12:105190396-105251121 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019018
 protein coding gene Chr12:107952980-108015797 (+)
WSB/EiJ MGP_WSBEiJ_G0019512
 protein coding gene Chr12:114684174-114748481 (+)



Homology
more
  • Human Ortholog
    PACS2, phosphofurin acidic cluster sorting protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PACS2, phosphofurin acidic cluster sorting protein 2
  • Synonyms
    DEE66, EIEE66, PACS1L, PACS-2
  • Links
    NCBI Gene ID: 23241
    neXtProt AC: NX_Q86VP3
    UniProt: Q86VP3

  • Chr Location
    14q32.33; chr14:105300563-105398147 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PACS2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit decreased sensitivity to TRAIL-induced spleen apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    886
  • Tissues
    21
  • cDNA Data
    109
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021143 Ensembl Gene Model | MGI Sequence Detail 59894 C57BL/6J ±  kb
    transcript ENSMUST00000223502 Ensembl | MGI Sequence Detail 3223 Not Applicable  
    polypeptide ENSMUSP00000152439 Ensembl | MGI Sequence Detail 894 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000012216 phosphofurin acidic cluster sorting protein 2
      (term hierarchy)
    • InterPro Domains
      IPR019381 Phosphofurin acidic cluster sorting protein 1
    • GlyGen
      Q3V3Q7 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 109
      cDNA 109

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2145014, MGI:2145027
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 19
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:349704 Krzysiak TC, et al., Inhibitory protein-protein interactions of the SIRT1 deacetylase are choreographed by post-translational modification. Protein Sci. 2024 Apr;33(4):e4938
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory