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Atp6v0d2 Gene Detail
Summary
  • Symbol
    Atp6v0d2
  • Name
    ATPase, H+ transporting, lysosomal V0 subunit D2
  • Synonyms
    1620401A02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924415
    NCBI Gene: 242341
  • Alliance
    gene page
  • Transcription Start Sites
    43 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:19876838-19922566 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 7.67 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1729 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924415
 protein coding gene Chr4:19876838-19922605 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028085
 protein coding gene Chr4:16881556-16927093 (-)
A/J MGP_AJ_G0028043
 protein coding gene Chr4:16427705-16477837 (-)
AKR/J MGP_AKRJ_G0028008
 protein coding gene Chr4:16783462-16834084 (-)
BALB/cJ MGP_BALBcJ_G0028054
 protein coding gene Chr4:16402755-16448567 (-)
C3H/HeJ MGP_C3HHeJ_G0027784
 protein coding gene Chr4:16888360-16941469 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028497
 protein coding gene Chr4:17570497-17619721 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025839
 protein coding gene Chr4:15203512-15249690 (-)
CAST/EiJ MGP_CASTEiJ_G0027239
 protein coding gene Chr4:16710296-16763453 (-)
CBA/J MGP_CBAJ_G0027757
 protein coding gene Chr4:18078407-18127259 (-)
DBA/2J MGP_DBA2J_G0027900
 protein coding gene Chr4:16240337-16290567 (-)
FVB/NJ MGP_FVBNJ_G0027866
 protein coding gene Chr4:15965155-16012661 (-)
LP/J MGP_LPJ_G0028009
 protein coding gene Chr4:16937452-16983376 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027899
 protein coding gene Chr4:19135657-19184045 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028556
 protein coding gene Chr4:16681128-16730227 (-)
PWK/PhJ MGP_PWKPhJ_G0026959
 protein coding gene Chr4:16138766-16189165 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026788
 protein coding gene Chr4:16544470-16597555 (-)
WSB/EiJ MGP_WSBEiJ_G0027316
 protein coding gene Chr4:16725424-16773842 (-)



Homology
more
  • Human Ortholog
    ATP6V0D2, ATPase H+ transporting V0 subunit d2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ATP6V0D2, ATPase H+ transporting V0 subunit d2
  • Synonyms
    ATP6D2, VMA6
  • Links
    NCBI Gene ID: 245972
    neXtProt AC: NX_Q8N8Y2
    UniProt: Q8N8Y2

  • Chr Location
    8q21.3; chr8:85987323-86154225 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display osteopetrosis and impaired osteoclast maturation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    840
  • Tissues
    113
  • cDNA Data
    23
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 242341 NCBI Gene Model | MGI Sequence Detail 45729 C57BL/6J ±  kb
    transcript NM_175406 RefSeq | MGI Sequence Detail 2518 C57BL/6  
    polypeptide Q80SY3 UniProt | EBI | MGI Sequence Detail 350 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 23
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2140238
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 9
      Gene Ontology 8
      Phenotypes 10
    • Earliest
      J:115141 Hackam DJ, et al., Host resistance to intracellular infection: mutation of natural resistance-associated macrophage protein 1 (Nramp1) impairs phagosomal acidification. J Exp Med. 1998 Jul 20;188(2):351-64
    • Latest
      J:344583 Shin YK, et al., Regulation of the V-ATPase subunit ATP6V0D2 and its role in demyelination after peripheral nerve injury. Biochem Biophys Res Commun. 2023 Feb 26;646:1-7
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory