Rspo4 MGI Mouse Gene Detail - MGI:1924467

Symbol

Rspo4
Name

R-spondin 4
Synonyms

A930029K19Rik

Feature Type

protein coding gene
IDs

MGI:1924467
NCBI Gene: 228770
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr2:151684847-151716588 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 74.83 cM
Mapping Data

1 experiment

SNPs within 2kb

1110 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1924467	protein coding gene	Chr2:151684571-151716588 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026646	protein coding gene	Chr2:156349550-156382834 (+)
A/J	MGP_AJ_G0026612	protein coding gene	Chr2:150124387-150157289 (+)
AKR/J	MGP_AKRJ_G0026582	protein coding gene	Chr2:154496823-154530547 (+)
BALB/cJ	MGP_BALBcJ_G0026621	protein coding gene	Chr2:150436284-150468144 (+)
C3H/HeJ	MGP_C3HHeJ_G0026364	protein coding gene	Chr2:154888927-154920719 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027070	protein coding gene	Chr2:160916067-160949380 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024441	protein coding gene	Chr2:143742519-143774936 (+)
CAST/EiJ	MGP_CASTEiJ_G0025825	protein coding gene	Chr2:155120450-155152275 (+)
CBA/J	MGP_CBAJ_G0026342	protein coding gene	Chr2:166785614-166819607 (+)
DBA/2J	MGP_DBA2J_G0026478	protein coding gene	Chr2:149348779-149380520 (+)
FVB/NJ	MGP_FVBNJ_G0026443	protein coding gene	Chr2:147786341-147818586 (+)
LP/J	MGP_LPJ_G0026582	protein coding gene	Chr2:156518054-156551245 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026465	protein coding gene	Chr2:170956462-170989006 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027125	protein coding gene	Chr2:154381375-154414566 (+)
PWK/PhJ	MGP_PWKPhJ_G0025559	protein coding gene	Chr2:148870601-148903183 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025362	protein coding gene	Chr2:153214849-153250484 (+)
WSB/EiJ	MGP_WSBEiJ_G0025895	protein coding gene	Chr2:155309238-155341765 (+)

Human Ortholog

RSPO4, R-spondin 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RSPO4, R-spondin 4
Synonyms

C20orf182, CRISTIN4
Links

HGNC:16175

NCBI Gene ID: 343637

neXtProt AC: NX_Q2I0M5

UniProt: Q2I0M5
Chr Location

20p13; chr20:958452-1002311 (-) GRCh38

MGI Vertebrate Homology

Rspo4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RSPO4
Gene Tree

Rspo4

Diseases

1 with human RSPO4 associations

				Human Disease	Mouse Models
				nonsyndromic congenital nail disorder 4 IDs nonsyndromic congenital nail disorder 4 DOID:0080082 MESH:C536377 OMIM:206800

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

1
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Rspo4
Find Mice (IMSR)

12 strains or lines available

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All GO Annotations

9
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1001
Tissues

263
cDNA Data

14
Literature Summary

26

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

33
RefSeq

4
UniProt

3
CCDS

CCDS38272.1

Ensembl

ENSMUSG00000032852 (Evidence)
NCBI Gene

228770

			Length	Strain/Species	Flank
genomic	ENSMUSG00000032852	Ensembl Gene Model \| MGI Sequence Detail	31742	C57BL/6J	± kb
transcript	ENSMUST00000042217	Ensembl \| MGI Sequence Detail	2371	Not Applicable
polypeptide	ENSMUSP00000041578	Ensembl \| MGI Sequence Detail	228	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000014333 R-spondin-4

(term hierarchy)
InterPro Domains

IPR006212 Furin-like repeat

IPR009030 Growth factor receptor cysteine-rich domain superfamily

IPR051514 R-spondin domain-containing protein

IPR043601 R-spondin, Fu-CRD domain

IPR000884 Thrombospondin type-1 (TSP1) repeat
GlyGen

Q8BJ73 1 site

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All nucleic 22

cDNA 14

Primer pair 5

Other 3

Microarray probesets 2

Summaries

All 56

Developmental Gene Expression 26

Gene Ontology 6

Phenotypes 9
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rspo4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr20739	Chr2:151684832-151684854 (+)	-4 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24