Tmem116 MGI Mouse Gene Detail - MGI:1924712

Symbol

Tmem116
Name

transmembrane protein 116
Synonyms

4930406A18Rik, 4930513P12Rik, C030022K24Rik

Feature Type

protein coding gene
IDs

MGI:1924712
NCBI Gene: 77462
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr5:121590643-121656601 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 61.81 cM, cytoband F
Mapping Data

2 experiments

SNPs within 2kb

1597 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1924712	protein coding gene	Chr5:121589956-121662246 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030028	protein coding gene	Chr5:124936878-125017001 (+)
A/J	MGP_AJ_G0029993	protein coding gene	Chr5:119793700-119868089 (+)
AKR/J	MGP_AKRJ_G0029930	protein coding gene	Chr5:123669028-123744410 (+)
BALB/cJ	MGP_BALBcJ_G0030004	protein coding gene	Chr5:121177264-121254590 (+)
C3H/HeJ	MGP_C3HHeJ_G0029722	protein coding gene	Chr5:124233323-124312300 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030457	protein coding gene	Chr5:129696164-129775409 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027683	protein coding gene	Chr5:114475029-114536357 (+)
CAST/EiJ	MGP_CASTEiJ_G0029130	protein coding gene	Chr5:123345766-123421923 (+)
CBA/J	MGP_CBAJ_G0029691	protein coding gene	Chr5:134793850-134880026 (+)
DBA/2J	MGP_DBA2J_G0029841	protein coding gene	Chr5:119864872-119937474 (+)
FVB/NJ	MGP_FVBNJ_G0029798	protein coding gene	Chr5:118812893-118892892 (+)
LP/J	MGP_LPJ_G0029930	protein coding gene	Chr5:125454782-125530538 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029828	protein coding gene	Chr5:138653435-138731758 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030498	protein coding gene	Chr5:123184317-123266154 (+)
PWK/PhJ	MGP_PWKPhJ_G0028844	protein coding gene	Chr5:118635601-118714170 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028681	protein coding gene	Chr5:120949420-121024370 (+)
WSB/EiJ	MGP_WSBEiJ_G0029205	protein coding gene	Chr5:123840093-123920443 (+)

Human Ortholog

TMEM116, transmembrane protein 116

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TMEM116, transmembrane protein 116
Links

HGNC:25084

NCBI Gene ID: 89894

neXtProt AC: NX_Q8NCL8

UniProt: Q8NCL8
Chr Location

12q24.13; chr12:111931282-112013866 (-) GRCh38

MGI Vertebrate Homology

Tmem116 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TMEM116
Gene Tree

Tmem116

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Phenotype Summary

10 phenotypes from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

32
Chemically induced (other)

1
Gene trapped

26
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Tmem116
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

38 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

3
GO References

1

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

733
Tissues

14
cDNA Data

18
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

less

All Sequences

75
RefSeq

18
UniProt

10
CCDS

CCDS19635.1, CCDS51640.1, CCDS51641.1

Ensembl

ENSMUSG00000029452 (Evidence)
NCBI Gene

77462

			Length	Strain/Species	Flank
genomic	77462	NCBI Gene Model \| MGI Sequence Detail	65959	C57BL/6J	± kb
transcript	NM_001161627	RefSeq \| MGI Sequence Detail	1364	C57BL/6
polypeptide	NP_001155099	RefSeq \| MGI Sequence Detail	364	C57BL/6

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UniProt

10 Sequences
InterPro Domains

IPR022343 GCR1-cAMP receptor

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All nucleic 19

cDNA 18

Primer pair 1

Microarray probesets 4

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MGI:1918908, MGI:1921049

Summaries

All 32

Developmental Gene Expression 1

Gene Ontology 1

Phenotypes 14
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tmem116:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr48576	Chr5:121590228-121590242 (+)	-408 bp
Tssr48577	Chr5:121590669-121590728 (+)	56 bp
Tssr48578	Chr5:121590752-121590777 (+)	122 bp
Tssr48579	Chr5:121601213-121601252 (+)	10,590 bp
Tssr48580	Chr5:121601256-121601272 (+)	10,621 bp
Tssr48581	Chr5:121601274-121601285 (+)	10,637 bp
Tssr48582	Chr5:121621847-121621859 (+)	31,210 bp
Tssr48583	Chr5:121644971-121644975 (+)	54,330 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24