Kidins220 MGI Mouse Gene Detail - MGI:1924730 - kinase D-interacting substrate 220

Symbol

Kidins220
Name

kinase D-interacting substrate 220
Synonyms

3110039L19Rik, C330002I19Rik, mKIAA1250

Feature Type

protein coding gene
IDs

MGI:1924730
NCBI Gene: 77480
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr12:25024924-25113151 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 8.54 cM
Mapping Data

3 experiments

SNPs within 2kb

2730 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1924730	protein coding gene	Chr12:25024909-25113151 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019634	protein coding gene	Chr12:22669521-22757353 (+)
A/J	MGP_AJ_G0019601	protein coding gene	Chr12:22044376-22135706 (+)
AKR/J	MGP_AKRJ_G0019572	protein coding gene	Chr12:22782384-22873834 (+)
BALB/cJ	MGP_BALBcJ_G0019578	protein coding gene	Chr12:22314355-22402664 (+)
C3H/HeJ	MGP_C3HHeJ_G0019382	protein coding gene	Chr12:22669821-22763933 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020026	protein coding gene	Chr12:23382409-23472431 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017650	protein coding gene	Chr12:21525200-21613729 (+)
CAST/EiJ	MGP_CASTEiJ_G0018937	protein coding gene	Chr12:17646482-17738312 (+)
CBA/J	MGP_CBAJ_G0019353	protein coding gene	Chr12:24112420-24202649 (+)
DBA/2J	MGP_DBA2J_G0019467	protein coding gene	Chr12:21898810-21986719 (+)
FVB/NJ	MGP_FVBNJ_G0019458	protein coding gene	Chr12:21789847-21873842 (+)
LP/J	MGP_LPJ_G0019537	protein coding gene	Chr12:22740486-22834375 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019493	protein coding gene	Chr12:23976022-24069058 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020065	protein coding gene	Chr12:22359186-22452280 (+)
PWK/PhJ	MGP_PWKPhJ_G0018704	protein coding gene	Chr12:16641891-16728456 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018492	protein coding gene	Chr12:16858509-16949991 (+)
WSB/EiJ	MGP_WSBEiJ_G0018988	protein coding gene	Chr12:22504411-22596931 (+)

Human Ortholog

KIDINS220, kinase D interacting substrate 220

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KIDINS220, kinase D interacting substrate 220
Synonyms

ARMS, SINO, VENARG
Links

HGNC:29508

NCBI Gene ID: 57498

neXtProt AC: NX_Q9ULH0

UniProt: Q9ULH0
Chr Location

2p25.1; chr2:8721081-8837630 (-) GRCh38

MGI Vertebrate Homology

Kidins220 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: KIDINS220
Gene Tree

Kidins220

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Phenotype Summary

19 phenotypes from 2 alleles in 3 genetic backgrounds
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

2
Gene trapped

2
Targeted

6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

79 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit embryonic lethality. Mice heterozygous for a knock-out allele exhibit decreased dendritic complexity in the barrel somatosensory cortex and dentate gyrus neurons.

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All GO Annotations

12
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

968
Tissues

42
cDNA Data

13
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA KIDINS220

Xenbase kidins220

ZFIN kidins220b

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All Sequences

115
RefSeq

35
UniProt

17
CCDS

CCDS36424.1

Ensembl

ENSMUSG00000036333 (Evidence)
NCBI Gene

77480

			Length	Strain/Species	Flank
genomic	ENSMUSG00000036333	Ensembl Gene Model \| MGI Sequence Detail	88228	C57BL/6J	± kb
transcript	ENSMUST00000066652	Ensembl \| MGI Sequence Detail	7409	Not Applicable
polypeptide	ENSMUSP00000063999	Ensembl \| MGI Sequence Detail	1793	Not Applicable

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UniProt

17 Sequences
InterPro Domains

IPR002110 Ankyrin repeat

IPR036770 Ankyrin repeat-containing domain superfamily

IPR011646 KAP family P-loop domain

IPR052771 Neurotrophin-activated signaling adaptor

IPR013761 Sterile alpha motif/pointed domain superfamily
GlyGen

E9Q9B7 3 sites, 3 N-linked glycans (3 sites)

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All nucleic 19

cDNA 13

Primer pair 4

Other 2

Microarray probesets 9

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MGI:1920401, MGI:2144771, MGI:2144787

Summaries

All 48

Developmental Gene Expression 6

Gene Ontology 3

Phenotypes 18
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:350718 Sanchez-Sanchez J, et al., ARMS/Kidins220 regulates nociception by controlling brain-derived neurotrophic factor secretion. Pain. 2023 Mar 1;164(3):563-576

TSS for Kidins220:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr112971	Chr12:25023805-25023812 (+)	-1,115 bp
Tssr112972	Chr12:25023890-25023901 (+)	-1,028 bp
Tssr112973	Chr12:25024913-25024947 (+)	6 bp
Tssr112974	Chr12:25032268-25032285 (+)	7,353 bp
Tssr112975	Chr12:25039756-25039768 (+)	14,838 bp
Tssr112976	Chr12:25088354-25088379 (+)	63,443 bp
Tssr112977	Chr12:25090094-25090101 (+)	65,174 bp
Tssr112978	Chr12:25092661-25092665 (+)	67,739 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24