Alg9 MGI Mouse Gene Detail - MGI:1924753 - ALG9 alpha-1,2-mannosyltransferase

Symbol

Alg9
Name

ALG9 alpha-1,2-mannosyltransferase
Synonyms

8230402H15Rik, B430313H07Rik, Dibd1

Feature Type

protein coding gene
IDs

MGI:1924753
NCBI Gene: 102580
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr9:50686570-50754939 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 27.75 cM
Mapping Data

2 experiments

SNPs within 2kb

2078 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1924753	protein coding gene	Chr9:50686319-50754939 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034792	protein coding gene	Chr9:49677409-49749845 (+)
A/J	MGP_AJ_G0034773	protein coding gene	Chr9:48162727-48231553 (+)
AKR/J	MGP_AKRJ_G0034701	protein coding gene	Chr9:49172560-49243706 (+)
BALB/cJ	MGP_BALBcJ_G0034765	protein coding gene	Chr9:47887029-47973034 (+)
C3H/HeJ	MGP_C3HHeJ_G0034475	protein coding gene	Chr9:49664471-49735890 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035285	protein coding gene	Chr9:51062096-51132961 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032198	protein coding gene	Chr9:47623617-47695071 (+)
CAST/EiJ	MGP_CASTEiJ_G0033797	protein coding gene	Chr9:49611555-49681306 (+)
CBA/J	MGP_CBAJ_G0034447	protein coding gene	Chr9:52868183-52960762 (+)
DBA/2J	MGP_DBA2J_G0034606	protein coding gene	Chr9:48021006-48096120 (+)
FVB/NJ	MGP_FVBNJ_G0034547	protein coding gene	Chr9:47236396-47311363 (+)
LP/J	MGP_LPJ_G0034687	protein coding gene	Chr9:50036242-50110985 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034590	protein coding gene	Chr9:54464371-54543431 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035306	protein coding gene	Chr9:49154414-49230619 (+)
PWK/PhJ	MGP_PWKPhJ_G0033502	protein coding gene	Chr9:47999128-48069226 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033337	protein coding gene	Chr9:49460316-49530611 (+)
WSB/EiJ	MGP_WSBEiJ_G0033910	protein coding gene	Chr9:49158111-49228455 (+)

Human Ortholog

ALG9, ALG9 alpha-1,2-mannosyltransferase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ALG9, ALG9 alpha-1,2-mannosyltransferase
Synonyms

CDG1L, DIBD1, GIKANIS, LOH11CR1J
Links

HGNC:15672

NCBI Gene ID: 79796

neXtProt AC: NX_Q9H6U8

UniProt: Q9H6U8
Chr Location

11q23.1; chr11:111768025-111871581 (-) GRCh38

MGI Vertebrate Homology

Alg9 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ALG9
Gene Tree

Alg9

Diseases

1 with human ALG9 associations

				Human Disease	Mouse Models
				congenital disorder of glycosylation Il IDs congenital disorder of glycosylation Il DOID:0080564 OMIM:608776 ORDO:79328

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

3
Gene trapped

3
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

36 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

13
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

707
Tissues

1
cDNA Data

58
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase alg9

ZFIN alg9

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All Sequences

81
RefSeq

25
UniProt

5
CCDS

CCDS23175.1

Ensembl

ENSMUSG00000032059 (Evidence)
NCBI Gene

102580

			Length	Strain/Species	Flank
genomic	102580	NCBI Gene Model \| MGI Sequence Detail	68370	C57BL/6J	± kb
transcript	NM_133981	RefSeq \| MGI Sequence Detail	2695	C57BL/6
polypeptide	Q8VDI9	UniProt \| EBI \| MGI Sequence Detail	611	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000003947 alpha-1,2-mannosyltransferase ALG9

(term hierarchy)
EC

2.4.1.-, 2.4.1.259, 2.4.1.261
InterPro Domains

IPR005599 GPI mannosyltransferase
GlyGen

Q8VDI9 3 sites, 1 N-linked glycan (1 site)

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All nucleic 58

cDNA 58

Microarray probesets 3

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MGI:1925236, MGI:2143117

Summaries

All 34

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 8
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Alg9:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr85070	Chr9:50685519-50685527 (+)	-1,047 bp
Tssr85071	Chr9:50686579-50686627 (+)	33 bp
Tssr85072	Chr9:50686647-50686669 (+)	88 bp
Tssr85073	Chr9:50686675-50686680 (+)	108 bp
Tssr85074	Chr9:50714809-50714821 (+)	28,245 bp
Tssr85075	Chr9:50746602-50746629 (+)	60,046 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24