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Apex2 Gene Detail
Summary
  • Symbol
    Apex2
  • Name
    apurinic/apyrimidinic endonuclease 2
  • Synonyms
    Ape2, C430040P13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924872
    NCBI Gene: 77622
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:149302515-149372864 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 68.46 cM, cytoband F2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1449 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924872
 protein coding gene ChrX:149286625-149372864 (-)
129S1/SvImJ MGP_129S1SvImJ_G0036168
 protein coding gene ChrX:148249693-148324057 (-)
A/J MGP_AJ_G0036144
 protein coding gene ChrX:147453345-147529144 (-)
AKR/J MGP_AKRJ_G0036070
 protein coding gene ChrX:152252214-152315184 (-)
BALB/cJ MGP_BALBcJ_G0036135
 protein coding gene ChrX:145656297-145725363 (-)
C3H/HeJ MGP_C3HHeJ_G0035843
 protein coding gene ChrX:148448712-148515976 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036660
 protein coding gene ChrX:152414155-152485118 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033484
 protein coding gene ChrX:139302166-139368575 (-)
CAST/EiJ MGP_CASTEiJ_G0035135
 protein coding gene ChrX:127952735-127964382 (-)
CBA/J MGP_CBAJ_G0035820
 protein coding gene ChrX:156981313-157050289 (-)
DBA/2J MGP_DBA2J_G0035978
 protein coding gene ChrX:146556505-146625402 (-)
FVB/NJ MGP_FVBNJ_G0035912
 protein coding gene ChrX:145710287-145775763 (-)
LP/J MGP_LPJ_G0036069
 protein coding gene ChrX:149308569-149379309 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035948
 protein coding gene ChrX:165015272-165086511 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036695
 protein coding gene ChrX:147764846-147829276 (-)
PWK/PhJ MGP_PWKPhJ_G0034828
 protein coding gene ChrX:124881088-124947636 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034654
 protein coding gene ChrX:128368368-128434596 (-)
WSB/EiJ MGP_WSBEiJ_G0035269
 protein coding gene ChrX:145846059-145914276 (-)



Homology
more
  • Human Ortholog
    APEX2, apurinic/apyrimidinic endodeoxyribonuclease 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    APEX2, apurinic/apyrimidinic endodeoxyribonuclease 2
  • Synonyms
    APE2, APEXL2, XTH2, ZGRF2
  • Links
    NCBI Gene ID: 27301
    neXtProt AC: NX_Q9UBZ4
    UniProt: Q9UBZ4

  • Chr Location
    Xp11.21; chrX:55000363-55009057 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 2 alleles in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Hemizygous null male mice display mild growth retardation, thymic atrophy, reduced white blood cell counts, and a slight decrease in red blood cell count.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    38
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025269 Ensembl Gene Model | MGI Sequence Detail 70350 C57BL/6J ±  kb
    transcript ENSMUST00000112721 Ensembl | MGI Sequence Detail 1852 Not Applicable  
    polypeptide ENSMUSP00000108341 Ensembl | MGI Sequence Detail 523 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 38
      cDNA 38

      Microarray probesets 3
    References
    more
    • Summaries
      All 41
      Gene Ontology 7
      Phenotypes 18
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory