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Sphkap Gene Detail
Summary
  • Symbol
    Sphkap
  • Name
    SPHK1 interactor, AKAP domain containing
  • Synonyms
    4930544G21Rik, A930009L15Rik, mKIAA1678, SKIP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924879
    NCBI Gene: 77629
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:83233163-83385853 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 42.73 cM, cytoband C5
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4145 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924879
 protein coding gene Chr1:83231860-83385921 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016225
 protein coding gene Chr1:84231487-84390370 (-)
A/J MGP_AJ_G0016208
 protein coding gene Chr1:81227122-81384877 (-)
AKR/J MGP_AKRJ_G0016165
 protein coding gene Chr1:83436282-83601276 (-)
BALB/cJ MGP_BALBcJ_G0016163
 protein coding gene Chr1:81373391-81526741 (-)
C3H/HeJ MGP_C3HHeJ_G0015993
 protein coding gene Chr1:83814392-83985964 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016616
 protein coding gene Chr1:87484471-87658814 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014336
 protein coding gene Chr1:76414240-76555801 (-)
CAST/EiJ MGP_CASTEiJ_G0015578
 protein coding gene Chr1:83255544-83414019 (-)
CBA/J MGP_CBAJ_G0015967
 protein coding gene Chr1:90272141-90455704 (-)
DBA/2J MGP_DBA2J_G0016068
 protein coding gene Chr1:80491882-80646878 (-)
FVB/NJ MGP_FVBNJ_G0016071
 protein coding gene Chr1:79614021-79767327 (-)
LP/J MGP_LPJ_G0016141
 protein coding gene Chr1:85331675-85486592 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016091
 protein coding gene Chr1:93632312-93799874 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016663
 protein coding gene Chr1:83618576-83782525 (-)
PWK/PhJ MGP_PWKPhJ_G0015364
 protein coding gene Chr1:79953360-80110934 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015142
 protein coding gene Chr1:82804916-82952561 (-)
WSB/EiJ MGP_WSBEiJ_G0015639
 protein coding gene Chr1:83400615-83555800 (-)



Homology
more
  • Human Ortholog
    SPHKAP, SPHK1 interactor, AKAP domain containing
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPHKAP, SPHK1 interactor, AKAP domain containing
  • Synonyms
    SKIP
  • Links
    NCBI Gene ID: 80309
    neXtProt AC: NX_Q2M3C7
    UniProt: Q2M3C7

  • Chr Location
    2q36.3; chr2:227979955-228181687 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased glucose-stimulated insulin secretion under high glucose conditions.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    846
  • Tissues
    28
  • cDNA Data
    13
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 77629 NCBI Gene Model | MGI Sequence Detail 152691 C57BL/6J ±  kb
    transcript NM_001405284 RefSeq | MGI Sequence Detail 7598 C57BL/6  
    polypeptide Q6NSW3 UniProt | EBI | MGI Sequence Detail 1687 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000015524 A-kinase anchor protein SPHKAP
      (term hierarchy)
    • InterPro Domains
      IPR018292 A-kinase anchor 110kDa, C-terminal
      IPR008382 SPHK1-interactor/A-kinase anchor 110kDa
    • GlyGen
      Q6NSW3 8 sites, 3 N-linked glycans (3 sites), 1 O-linked glycan (5 sites)
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 14
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1925196, MGI:2138360
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 7
      Gene Ontology 3
      Phenotypes 8
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    12/10/2024
    MGI 6.24     		The Jackson Laboratory