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Slf2 Gene Detail
Summary
  • Symbol
    Slf2
  • Name
    SMC5-SMC6 complex localization factor 2
  • Synonyms
    6030443O07Rik, Fam178a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924968
    NCBI Gene: 226151
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:44919558-44972225 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 38.16 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1075 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924968
 protein coding gene Chr19:44906948-44972225 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025177
 protein coding gene Chr19:44462475-44517863 (+)
A/J MGP_AJ_G0025154
 protein coding gene Chr19:42328265-42381585 (+)
AKR/J MGP_AKRJ_G0025122
 protein coding gene Chr19:43683887-43741657 (+)
BALB/cJ MGP_BALBcJ_G0025148
 protein coding gene Chr19:42376954-42431665 (+)
C3H/HeJ MGP_C3HHeJ_G0024908
 protein coding gene Chr19:43834665-43891247 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025591
 protein coding gene Chr19:45551475-45609334 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023005
 protein coding gene Chr19:41596570-41648759 (+)
CAST/EiJ MGP_CASTEiJ_G0024373
 protein coding gene Chr19:43581884-43641095 (+)
CBA/J MGP_CBAJ_G0024888
 protein coding gene Chr19:47864185-47926285 (+)
DBA/2J MGP_DBA2J_G0025020
 protein coding gene Chr19:42145712-42198789 (+)
FVB/NJ MGP_FVBNJ_G0024981
 protein coding gene Chr19:41912757-41967168 (+)
LP/J MGP_LPJ_G0025106
 protein coding gene Chr19:44404265-44460118 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025012
 protein coding gene Chr19:47257196-47314943 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025649
 protein coding gene Chr19:43763973-43818094 (+)
PWK/PhJ MGP_PWKPhJ_G0024122
 protein coding gene Chr19:42052922-42106017 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023926
 protein coding gene Chr19:42457790-42514896 (+)
WSB/EiJ MGP_WSBEiJ_G0024443
 protein coding gene Chr19:43895687-43959111 (+)



Homology
more
  • Human Ortholog
    SLF2, SMC5-SMC6 complex localization factor 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLF2, SMC5-SMC6 complex localization factor 2
  • Synonyms
    ATELS1, C10orf6, FAM178A
  • Links
    NCBI Gene ID: 55719
    neXtProt AC: NX_Q8IX21
    UniProt: Q8IX21

  • Chr Location
    10q24.31; chr10:100912963-100965134 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SLF2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    21
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000036097 Ensembl Gene Model | MGI Sequence Detail 52668 C57BL/6J ±  kb
transcript ENSMUST00000096053 Ensembl | MGI Sequence Detail 6879 Not Applicable  
polypeptide ENSMUSP00000093758 Ensembl | MGI Sequence Detail 1163 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 21
    cDNA 21

    Microarray probesets 8
Other
Accession IDs
less
MGI:2147633, MGI:5897585
References
more
  • Summaries
    All 36
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory