Mrps5 MGI Mouse Gene Detail - MGI:1924971 - mitochondrial ribosomal protein S5

Symbol

Mrps5
Name

mitochondrial ribosomal protein S5

Feature Type

protein coding gene
IDs

MGI:1924971
NCBI Gene: 77721
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr2:127429346-127445906 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 62.05 cM, cytoband F3
Mapping Data

3 experiments

SNPs within 2kb

505 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1924971	protein coding gene	Chr2:127429142-127448749 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026464	protein coding gene	Chr2:130879875-130899482 (+)
A/J	MGP_AJ_G0026428	protein coding gene	Chr2:125577764-125597396 (+)
AKR/J	MGP_AKRJ_G0026403	protein coding gene	Chr2:129158188-129177795 (+)
BALB/cJ	MGP_BALBcJ_G0026440	protein coding gene	Chr2:125843753-125863877 (+)
C3H/HeJ	MGP_C3HHeJ_G0026183	protein coding gene	Chr2:129675193-129694862 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026885	protein coding gene	Chr2:134984420-135004118 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024262	protein coding gene	Chr2:120423139-120442559 (+)
CAST/EiJ	MGP_CASTEiJ_G0025644	protein coding gene	Chr2:129876082-129895742 (+)
CBA/J	MGP_CBAJ_G0026163	protein coding gene	Chr2:139981619-140001295 (+)
DBA/2J	MGP_DBA2J_G0026297	protein coding gene	Chr2:124983282-125003539 (+)
FVB/NJ	MGP_FVBNJ_G0026261	protein coding gene	Chr2:123636873-123657064 (+)
LP/J	MGP_LPJ_G0026402	protein coding gene	Chr2:131124752-131144359 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026281	protein coding gene	Chr2:143994290-144016059 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026940	protein coding gene	Chr2:129182537-129202144 (+)
PWK/PhJ	MGP_PWKPhJ_G0025380	protein coding gene	Chr2:124531983-124551707 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025182	protein coding gene	Chr2:128266219-128287286 (+)
WSB/EiJ	MGP_WSBEiJ_G0025718	protein coding gene	Chr2:130087962-130107575 (+)

Human Ortholog

MRPS5, mitochondrial ribosomal protein S5

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MRPS5, mitochondrial ribosomal protein S5
Synonyms

MRP-S5, S5mt, uS5m
Links

HGNC:14498

NCBI Gene ID: 64969

neXtProt AC: NX_P82675

UniProt: P82675
Chr Location

2q11.1; chr2:95085369-95122006 (-) GRCh38

MGI Vertebrate Homology

Mrps5 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MRPS5
Gene Tree

Mrps5

less

Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

34
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

23
Radiation induced

1
Targeted

7
Genomic Mutations

2 involving Mrps5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

46 strains or lines available

less

All GO Annotations

13
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

720
Tissues

13
cDNA Data

5
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mrps5

less

All Sequences

49
RefSeq

2
UniProt

3
CCDS

CCDS16706.1

Ensembl

ENSMUSG00000027374 (Evidence)
NCBI Gene

77721

			Length	Strain/Species	Flank
genomic	77721	NCBI Gene Model \| MGI Sequence Detail	16561	C57BL/6J	± kb
transcript	NM_029963	RefSeq \| MGI Sequence Detail	1448	Not Specified
polypeptide	Q99N87	UniProt \| EBI \| MGI Sequence Detail	432	Not Applicable

less

UniProt

3 Sequences
Protein Ontology

PR:000010643 small ribosomal subunit protein uS5m

(term hierarchy)
PDB

7PNT, 7PNU, 7PNV, 7PNW
InterPro Domains

IPR020568 Ribosomal protein uS5 domain 2-type superfamily

IPR000851 Small ribosomal subunit protein uS5

IPR005324 Small ribosomal subunit protein uS5, C-terminal

IPR014721 Small ribosomal subunit protein uS5 domain 2-type fold, subgroup

IPR048584 Small ribosomal subunit protein uS5m, N-terminal domain

IPR013810 Small ribosomal subunit protein uS5, N-terminal

IPR018192 Small ribosomal subunit protein uS5, N-terminal, conserved site

less

All nucleic 8

cDNA 7

Primer pair 1

Microarray probesets 8

less

MGI:2139078

Summaries

All 51

Developmental Gene Expression 1

Gene Ontology 8

Phenotypes 18
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Mrps5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr20024	Chr2:127429134-127429183 (+)	-187 bp
Tssr20025	Chr2:127429188-127429199 (+)	-152 bp
Tssr20026	Chr2:127429315-127429350 (+)	-13 bp
Tssr20027	Chr2:127432241-127432289 (+)	2,919 bp
Tssr20028	Chr2:127432662-127432679 (+)	3,325 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24