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Prickle2 Gene Detail
Summary
  • Symbol
    Prickle2
  • Name
    prickle planar cell polarity protein 2
  • Synonyms
    6230400G14Rik, 6720451F06Rik, mpk2, Pk2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1925144
    NCBI Gene: 243548
  • Alliance
    gene page
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:92347889-92683136 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 41.05 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    8337 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1925144
 protein coding gene Chr6:92347876-92683233 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031059
 protein coding gene Chr6:94016004-94368671 (-)
A/J MGP_AJ_G0031028
 protein coding gene Chr6:90439459-90781036 (-)
AKR/J MGP_AKRJ_G0030959
 protein coding gene Chr6:92934794-93287482 (-)
BALB/cJ MGP_BALBcJ_G0031039
 protein coding gene Chr6:90394993-90732539 (-)
C3H/HeJ MGP_C3HHeJ_G0030669
 protein coding gene Chr6:91148414-91498760 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031498
 protein coding gene Chr6:96426264-96790295 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028665
 protein coding gene Chr6:88403976-88751425 (-)
CAST/EiJ MGP_CASTEiJ_G0030146
 protein coding gene Chr6:93069052-93427604 (-)
CBA/J MGP_CBAJ_G0030725
 protein coding gene Chr6:100021383-100400018 (-)
DBA/2J MGP_DBA2J_G0030878
 protein coding gene Chr6:89609058-89945594 (-)
FVB/NJ MGP_FVBNJ_G0030832
 protein coding gene Chr6:88820188-89164558 (-)
LP/J MGP_LPJ_G0030958
 protein coding gene Chr6:93965578-94320365 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030866
 protein coding gene Chr6:104049549-104403762 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031525
 protein coding gene Chr6:92794549-93150265 (-)
PWK/PhJ MGP_PWKPhJ_G0029862
 protein coding gene Chr6:88570131-88924599 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029691
 protein coding gene Chr6:91712814-92050378 (-)
WSB/EiJ MGP_WSBEiJ_G0030230
 protein coding gene Chr6:93260058-93613865 (-)



Homology
more
  • Human Ortholog
    PRICKLE2, prickle planar cell polarity protein 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRICKLE2, prickle planar cell polarity protein 2
  • Synonyms
    EPM5
  • Links
    NCBI Gene ID: 166336
    neXtProt AC: NX_Q7Z3G6
    UniProt: Q7Z3G6

  • Chr Location
    3p14.1; chr3:64092236-64445476 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased susceptibility to electroconvulsive or PTZ-induced seizures. Mice heterozygous for a knock-out allele exhibit increased susceptibility to electroconvulsive seizures.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    23
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    897
  • Tissues
    166
  • cDNA Data
    50
  • Literature Summary
    28
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030020 Ensembl Gene Model | MGI Sequence Detail 335248 C57BL/6J ±  kb
transcript ENSMUST00000032093 Ensembl | MGI Sequence Detail 7754 Not Applicable  
polypeptide ENSMUSP00000032093 Ensembl | MGI Sequence Detail 901 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 55
    cDNA 51
    Primer pair 4

    Microarray probesets 4
Other
Accession IDs
less
MGI:1923374
References
more
  • Summaries
    All 73
    Developmental Gene Expression 28
    Gene Ontology 11
    Phenotypes 17
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:329316 Kunimoto K, et al., Distinct overlapping functions for Prickle1 and Prickle2 in the polarization of the airway epithelium. Front Cell Dev Biol. 2022;10:976182
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory