Yipf6 MGI Mouse Gene Detail - MGI:1925179 - Yip1 domain family, member 6

Symbol

Yipf6
Name

Yip1 domain family, member 6
Synonyms

A430107J06Rik, MGC:59484

Feature Type

protein coding gene
IDs

MGI:1925179
NCBI Gene: 77929
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

ChrX:97979922-97992623 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 43.19 cM, cytoband C2
Mapping Data

3 experiments

SNPs within 2kb

333 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1925179	protein coding gene	ChrX:97979922-97992627 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035933	protein coding gene	ChrX:95342735-95356369 (+)
A/J	MGP_AJ_G0035918	protein coding gene	ChrX:95400422-95413146 (+)
AKR/J	MGP_AKRJ_G0035834	protein coding gene	ChrX:98132218-98146421 (+)
BALB/cJ	MGP_BALBcJ_G0035901	protein coding gene	ChrX:94184788-94197716 (+)
C3H/HeJ	MGP_C3HHeJ_G0035610	protein coding gene	ChrX:95785153-95797896 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0036430	protein coding gene	ChrX:98267895-98280567 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033260	protein coding gene	ChrX:93247061-93260034 (+)
CAST/EiJ	MGP_CASTEiJ_G0034897	protein coding gene	ChrX:80114728-80127658 (+)
CBA/J	MGP_CBAJ_G0035585	protein coding gene	ChrX:101287886-101301291 (+)
DBA/2J	MGP_DBA2J_G0035739	protein coding gene	ChrX:94657882-94670612 (+)
FVB/NJ	MGP_FVBNJ_G0035677	protein coding gene	ChrX:94053269-94066080 (+)
LP/J	MGP_LPJ_G0035829	protein coding gene	ChrX:96336515-96350397 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035712	protein coding gene	ChrX:105771855-105786166 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036457	protein coding gene	ChrX:95083460-95096814 (+)
PWK/PhJ	MGP_PWKPhJ_G0034596	protein coding gene	ChrX:77762844-77775838 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034424	protein coding gene	ChrX:80960971-80974509 (+)
WSB/EiJ	MGP_WSBEiJ_G0035036	protein coding gene	ChrX:93803111-93816808 (+)

Human Ortholog

YIPF6, Yip1 domain family member 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

YIPF6, Yip1 domain family member 6
Synonyms

FinGER6, Yip4, YIPFalpha3
Links

HGNC:28304

NCBI Gene ID: 286451

neXtProt AC: NX_Q96EC8

UniProt: Q96EC8
Chr Location

Xq12-q13.1; chrX:68498562-68537282 (+) GRCh38

MGI Vertebrate Homology

Yipf6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: YIPF6
Gene Tree

Yipf6

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Phenotype Summary

14 phenotypes from 2 alleles in 2 genetic backgrounds
5 images
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (ENU)

1
Endonuclease-mediated

3
Gene trapped

1
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

7 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous or hemizygous for an ENU-induced allele exhibit colitis and increased susceptibility to induced colitis with decreased Paneth and goblet cells.

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All GO Annotations

15
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

66

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase yipf6

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All Sequences

59
RefSeq

9
UniProt

3
CCDS

CCDS30296.1

Ensembl

ENSMUSG00000047694 (Evidence)
NCBI Gene

77929

			Length	Strain/Species	Flank
genomic	ENSMUSG00000047694	Ensembl Gene Model \| MGI Sequence Detail	12702	C57BL/6J	± kb
transcript	ENSMUST00000054697	Ensembl \| MGI Sequence Detail	5211	Not Applicable
polypeptide	ENSMUSP00000056039	Ensembl \| MGI Sequence Detail	236	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000017536 protein YIPF6

(term hierarchy)
InterPro Domains

IPR045231 Protein Yip1/4-like

IPR006977 Yip1 domain

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All nucleic 68

cDNA 68

Microarray probesets 6

Summaries

All 37

Gene Ontology 7

Phenotypes 9
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Yipf6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr161587	ChrX:97979920-97979924 (+)	0 bp
Tssr161588	ChrX:97981074-97981144 (+)	1,187 bp
Tssr161589	ChrX:97981354-97981402 (+)	1,456 bp
Tssr161590	ChrX:97981784-97981804 (+)	1,872 bp
Tssr161591	ChrX:97981806-97981835 (+)	1,899 bp
Tssr161592	ChrX:97992201-97992205 (+)	12,281 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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