Cyp20a1 MGI Mouse Gene Detail - MGI:1925201 - cytochrome P450, family 20, subfamily a, polypeptide 1

Symbol

Cyp20a1
Name

cytochrome P450, family 20, subfamily a, polypeptide 1
Synonyms

A930011N14Rik

Feature Type

protein coding gene
IDs

MGI:1925201
NCBI Gene: 77951
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr1:60382482-60427219 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 30.47 cM, cytoband C2
Mapping Data

2 experiments

SNPs within 2kb

1581 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1925201	protein coding gene	Chr1:60382459-60427219 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016076	protein coding gene	Chr1:60416467-60467012 (+)
A/J	MGP_AJ_G0016059	protein coding gene	Chr1:58264408-58310401 (+)
AKR/J	MGP_AKRJ_G0016015	protein coding gene	Chr1:59922092-59968802 (+)
BALB/cJ	MGP_BALBcJ_G0016014	protein coding gene	Chr1:58299111-58344346 (+)
C3H/HeJ	MGP_C3HHeJ_G0015846	protein coding gene	Chr1:60165192-60209914 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016467	protein coding gene	Chr1:62761637-62808509 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014188	protein coding gene	Chr1:54478227-54525092 (+)
CAST/EiJ	MGP_CASTEiJ_G0015428	protein coding gene	Chr1:59357976-59410106 (+)
CBA/J	MGP_CBAJ_G0015818	protein coding gene	Chr1:64740432-64798344 (+)
DBA/2J	MGP_DBA2J_G0015919	protein coding gene	Chr1:57696027-57741887 (+)
FVB/NJ	MGP_FVBNJ_G0015921	protein coding gene	Chr1:56989238-57034835 (+)
LP/J	MGP_LPJ_G0015991	protein coding gene	Chr1:61287658-61334577 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015941	protein coding gene	Chr1:67620639-67671032 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016514	protein coding gene	Chr1:59812821-59860515 (+)
PWK/PhJ	MGP_PWKPhJ_G0015215	protein coding gene	Chr1:57048736-57094421 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0014995	protein coding gene	Chr1:59356371-59403550 (+)
WSB/EiJ	MGP_WSBEiJ_G0015491	protein coding gene	Chr1:59529346-59576653 (+)

Human Ortholog

CYP20A1, cytochrome P450 family 20 subfamily A member 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CYP20A1, cytochrome P450 family 20 subfamily A member 1
Synonyms

CYP-M
Links

HGNC:20576

NCBI Gene ID: 57404

neXtProt AC: NX_Q6UW02

UniProt: Q6UW02
Chr Location

2q33.2; chr2:203238977-203306026 (+) GRCh38

MGI Vertebrate Homology

Cyp20a1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CYP20A1
Gene Tree

Cyp20a1

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

6
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Cyp20a1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

40 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

5
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

759
Tissues

16
cDNA Data

27
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cyp20a1

ZFIN cyp20a1

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All Sequences

40
RefSeq

6
UniProt

3
CCDS

CCDS14990.1

Ensembl

ENSMUSG00000049439 (Evidence)
NCBI Gene

77951

			Length	Strain/Species	Flank
genomic	ENSMUSG00000049439	Ensembl Gene Model \| MGI Sequence Detail	44738	C57BL/6J	± kb
transcript	ENSMUST00000060608	Ensembl \| MGI Sequence Detail	2223	Not Applicable
polypeptide	ENSMUSP00000050823	Ensembl \| MGI Sequence Detail	462	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000006104 cytochrome P450 20A1

(term hierarchy)
EC

1.14.-.-
InterPro Domains

IPR001128 Cytochrome P450

IPR052666 Cytochrome P450 20A1-like

IPR002401 Cytochrome P450, E-class, group I

IPR036396 Cytochrome P450 superfamily
GlyGen

Q8BKE6 1 site, 1 N-linked glycan (1 site)

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All nucleic 28

cDNA 27

Primer pair 1

Microarray probesets 5

Summaries

All 39

Developmental Gene Expression 2

Gene Ontology 3

Phenotypes 14
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cyp20a1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr6922	Chr1:60382456-60382521 (+)	7 bp
Tssr6923	Chr1:60382525-60382544 (+)	53 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24