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Lpar4 Gene Detail
Summary
  • Symbol
    Lpar4
  • Name
    lysophosphatidic acid receptor 4
  • Synonyms
    5730485F04Rik, Gpr23, LPA4, p2y9
  • Feature Type
    protein coding gene
  • IDs
    MGI:1925384
    NCBI Gene: 78134
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:105964231-105977505 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 47.39 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    270 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1925384
 protein coding gene ChrX:105964231-105977506 (+)
129S1/SvImJ MGP_129S1SvImJ_G0036010
 protein coding gene ChrX:103734293-103747633 (+)
A/J MGP_AJ_G0035989
 protein coding gene ChrX:103565170-103580910 (+)
AKR/J MGP_AKRJ_G0035908
 protein coding gene ChrX:106842366-106855639 (+)
BALB/cJ MGP_BALBcJ_G0035980
 protein coding gene ChrX:102344651-102357920 (+)
C3H/HeJ MGP_C3HHeJ_G0035686
 protein coding gene ChrX:104199996-104213589 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036506
 protein coding gene ChrX:106747936-106763839 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033334
 protein coding gene ChrX:100930415-100943784 (+)
CAST/EiJ MGP_CASTEiJ_G0034973
 protein coding gene ChrX:88334653-88349100 (+)
CBA/J MGP_CBAJ_G0035662
 protein coding gene ChrX:110076584-110089828 (+)
DBA/2J MGP_DBA2J_G0035816
 protein coding gene ChrX:102806363-102822057 (+)
FVB/NJ MGP_FVBNJ_G0035756
 protein coding gene ChrX:102147575-102160522 (+)
LP/J MGP_LPJ_G0035908
 protein coding gene ChrX:104684770-104698011 (+)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0036533
 protein coding gene ChrX:103362275-103375544 (+)
PWK/PhJ MGP_PWKPhJ_G0034669
 protein coding gene ChrX:85867915-85881192 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034498
 protein coding gene ChrX:89126354-89140488 (+)
WSB/EiJ MGP_WSBEiJ_G0035111
 protein coding gene ChrX:102075941-102089349 (+)



Homology
more
  • Human Ortholog
    LPAR4, lysophosphatidic acid receptor 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LPAR4, lysophosphatidic acid receptor 4
  • Synonyms
    GPR23, LPA4, P2RY9, P2Y5-LIKE, P2Y9
  • Links
    NCBI Gene ID: 2846
    neXtProt AC: NX_Q99677
    UniProt: Q99677

  • Chr Location
    Xq21.1; chrX:78747709-78758714 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
A subset of mice homozygous for a null allele fail to survive gestation and exhibit hemorrhages and/or edema in many organs at multiple embryonic stages, as well as dilated blood and lymphatic vessels, and impaired recruitment of smooth muscle cells and pericytes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1120
  • Tissues
    151
  • cDNA Data
    29
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 78134 NCBI Gene Model | MGI Sequence Detail 13275 C57BL/6J ±  kb
    transcript NM_175271 RefSeq | MGI Sequence Detail 4237 C57BL/6  
    polypeptide Q8BLG2 UniProt | EBI | MGI Sequence Detail 370 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 38
      cDNA 29
      Primer pair 8
      Other 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 12
      Gene Ontology 5
      Phenotypes 17
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory