Armcx1 MGI Mouse Gene Detail - MGI:1925498 - armadillo repeat containing, X-linked 1

Symbol

Armcx1
Name

armadillo repeat containing, X-linked 1
Synonyms

3010033I09Rik

Feature Type

protein coding gene
IDs

MGI:1925498
NCBI Gene: 78248
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

ChrX:133618712-133622666 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 56.24 cM, cytoband E3
Mapping Data

3 experiments

SNPs within 2kb

149 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1925498	protein coding gene	ChrX:133618615-133623487 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0036075	protein coding gene	ChrX:131906498-131910411 (+)
A/J	MGP_AJ_G0036055	protein coding gene	ChrX:131333566-131337490 (+)
AKR/J	MGP_AKRJ_G0035977	protein coding gene	ChrX:135541165-135545078 (+)
BALB/cJ	MGP_BALBcJ_G0036048	protein coding gene	ChrX:129772210-129776123 (+)
C3H/HeJ	MGP_C3HHeJ_G0035751	protein coding gene	ChrX:131993512-131997425 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0036570	protein coding gene	ChrX:135794337-135798291 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033398	protein coding gene	ChrX:123505794-123509762 (+)
CAST/EiJ	MGP_CASTEiJ_G0035039	protein coding gene	ChrX:112860327-112864308 (+)
CBA/J	MGP_CBAJ_G0035729	protein coding gene	ChrX:139874961-139878874 (+)
DBA/2J	MGP_DBA2J_G0035883	protein coding gene	ChrX:130638226-130642139 (+)
FVB/NJ	MGP_FVBNJ_G0035824	protein coding gene	ChrX:129963451-129967405 (+)
LP/J	MGP_LPJ_G0035976	protein coding gene	ChrX:132793497-132797410 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035853	protein coding gene	ChrX:147233278-147237232 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036600	protein coding gene	ChrX:131346283-131350237 (+)
PWK/PhJ	MGP_PWKPhJ_G0034731	protein coding gene	ChrX:109805759-109809849 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034562	protein coding gene	ChrX:113510868-113514889 (+)
WSB/EiJ	MGP_WSBEiJ_G0035177	protein coding gene	ChrX:129717842-129721792 (+)

Human Ortholog

ARMCX1, armadillo repeat containing X-linked 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ARMCX1, armadillo repeat containing X-linked 1
Synonyms

ALEX1, GASP7
Links

HGNC:18073

NCBI Gene ID: 51309

neXtProt AC: NX_Q9P291

UniProt: Q9P291
Chr Location

Xq22.1; chrX:101550547-101554700 (+) GRCh38

MGI Vertebrate Homology

Armcx1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ARMCX1
Gene Tree

Armcx1

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

2
Gene trapped

7
Targeted

1
Incidental Mutations

APF
Find Mice (IMSR)

6 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

3
GO References

3

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

772
Tissues

14
cDNA Data

11
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

72
RefSeq

22
UniProt

1
CCDS

CCDS30398.1

Ensembl

ENSMUSG00000033460 (Evidence)
NCBI Gene

78248

			Length	Strain/Species	Flank
genomic	ENSMUSG00000033460	Ensembl Gene Model \| MGI Sequence Detail	3955	C57BL/6J	± kb
transcript	ENSMUST00000113199	Ensembl \| MGI Sequence Detail	2413	Not Applicable
polypeptide	ENSMUSP00000108824	Ensembl \| MGI Sequence Detail	456	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000032088 armadillo repeat-containing X-linked protein 1

(term hierarchy)
InterPro Domains

IPR000225 Armadillo

IPR011989 Armadillo-like helical

IPR006911 Armadillo repeat-containing domain

IPR051303 Armadillo repeat-containing X-linked regulator

IPR016024 Armadillo-type fold

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All nucleic 13

cDNA 11

Primer pair 1

Other 1

Microarray probesets 2

Summaries

All 36

Developmental Gene Expression 4

Gene Ontology 3

Phenotypes 9
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Armcx1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr162011	ChrX:133618663-133618669 (+)	-46 bp
Tssr162012	ChrX:133618679-133618690 (+)	-27 bp
Tssr162013	ChrX:133618692-133618767 (+)	18 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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