Map4k5 MGI Mouse Gene Detail - MGI:1925503 - mitogen-activated protein kinase kinase kinase kinase 5

Symbol

Map4k5
Name

mitogen-activated protein kinase kinase kinase kinase 5
Synonyms

4432415E19Rik, GCKR, KHS, MAPKKKK5

Feature Type

protein coding gene
IDs

MGI:1925503
NCBI Gene: 399510
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr12:69850531-69939937 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 28.94 cM, cytoband C3
Mapping Data

2 experiments

SNPs within 2kb

2261 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1925503	protein coding gene	Chr12:69850524-69939974 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019802	protein coding gene	Chr12:69517031-69609342 (-)
A/J	MGP_AJ_G0019760	protein coding gene	Chr12:66925770-67020151 (-)
AKR/J	MGP_AKRJ_G0019736	protein coding gene	Chr12:68929431-69022279 (-)
BALB/cJ	MGP_BALBcJ_G0019740	protein coding gene	Chr12:67391179-67481861 (-)
C3H/HeJ	MGP_C3HHeJ_G0019546	protein coding gene	Chr12:69399011-69492478 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020192	protein coding gene	Chr12:71742602-71838421 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017812	protein coding gene	Chr12:64467113-64558476 (-)
CAST/EiJ	MGP_CASTEiJ_G0019097	protein coding gene	Chr12:64153265-64246230 (-)
CBA/J	MGP_CBAJ_G0019515	protein coding gene	Chr12:74391493-74491610 (-)
DBA/2J	MGP_DBA2J_G0019631	protein coding gene	Chr12:66840199-66934246 (-)
FVB/NJ	MGP_FVBNJ_G0019618	protein coding gene	Chr12:65739642-65832724 (-)
LP/J	MGP_LPJ_G0019703	protein coding gene	Chr12:69481926-69576692 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019657	protein coding gene	Chr12:77706818-77808799 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020227	protein coding gene	Chr12:68411681-68504139 (-)
PWK/PhJ	MGP_PWKPhJ_G0018862	protein coding gene	Chr12:61110440-61200538 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018657	protein coding gene	Chr12:62783090-62877404 (-)
WSB/EiJ	MGP_WSBEiJ_G0019148	protein coding gene	Chr12:69038246-69129235 (-)

Human Ortholog

MAP4K5, mitogen-activated protein kinase kinase kinase kinase 5

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MAP4K5, mitogen-activated protein kinase kinase kinase kinase 5
Synonyms

GCKR, KHS, KHS1, MAPKKKK5
Links

HGNC:6867

NCBI Gene ID: 11183

neXtProt AC: NX_Q9Y4K4

UniProt: Q9Y4K4
Chr Location

14q22.1; chr14:50418501-50561126 (-) GRCh38

MGI Vertebrate Homology

Map4k5 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MAP4K5
Protein SuperFamily

MAPKKKK
Gene Tree

Map4k5

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Phenotype Summary

8 phenotypes from 3 alleles in 3 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

33
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

26
Targeted

4
Genomic Mutations

1 involving Map4k5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

75 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele are viable and phenotypically normal but show impaired canonical and noncanonical Wnt signaling in progenitor B lymphocytes. Mice homozygous for a gene trap exhibit hypoalgesia, increased serum IgG1 and an increased percentage of peripheral blood CD4+ cells.

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All GO Annotations

37
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

709
Tissues

3
cDNA Data

108
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase map4k5

ZFIN map4k5

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All Sequences

61
RefSeq

4
UniProt

3

Ensembl

ENSMUSG00000034761 (Evidence)
NCBI Gene

399510

			Length	Strain/Species	Flank
genomic	399510	NCBI Gene Model \| MGI Sequence Detail	89407	C57BL/6J	± kb
transcript	NM_201519	RefSeq \| MGI Sequence Detail	4490	C57BL/6
polypeptide	Q8BPM2	UniProt \| EBI \| MGI Sequence Detail	847	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000010146 mitogen-activated protein kinase kinase kinase kinase 5

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR001180 Citron homology (CNH) domain

IPR021160 Mitogen-activated protein (MAP) kinase kinase kinase kinase

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR050629 STE20/SPS1-related Proline-Alanine-rich Kinase

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All nucleic 109

cDNA 109

Microarray probesets 8

Summaries

All 43

Developmental Gene Expression 1

Gene Ontology 7

Phenotypes 16
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Map4k5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr116540	Chr12:69939936-69939950 (-)	-6 bp
Tssr116539	Chr12:69939908-69939925 (-)	20 bp
Tssr116538	Chr12:69939763-69939856 (-)	127 bp
Tssr116537	Chr12:69939553-69939566 (-)	377 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24