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Ralgps2 Gene Detail
Summary
  • Symbol
    Ralgps2
  • Name
    Ral GEF with PH domain and SH3 binding motif 2
  • Synonyms
    1810020P17Rik, 2210408F11Rik, 4921528G01Rik, 9130014M22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1925505
    NCBI Gene: 78255
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:156631736-156767196 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 67.71 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3589 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1925505
 protein coding gene Chr1:156631736-156767422 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016628
 protein coding gene Chr1:161785814-161924976 (-)
A/J MGP_AJ_G0016609
 protein coding gene Chr1:155278913-155412884 (-)
AKR/J MGP_AKRJ_G0016575
 protein coding gene Chr1:160018254-160155353 (-)
BALB/cJ MGP_BALBcJ_G0016570
 protein coding gene Chr1:155773913-155911628 (-)
C3H/HeJ MGP_C3HHeJ_G0016394
 protein coding gene Chr1:160153459-160283719 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017031
 protein coding gene Chr1:167330054-167481797 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014740
 protein coding gene Chr1:147471045-147607604 (-)
CAST/EiJ MGP_CASTEiJ_G0015974
 protein coding gene Chr1:159702760-159840217 (-)
CBA/J MGP_CBAJ_G0016369
 protein coding gene Chr1:173251775-173403401 (-)
DBA/2J MGP_DBA2J_G0016475
 protein coding gene Chr1:154223432-154357252 (-)
FVB/NJ MGP_FVBNJ_G0016473
 protein coding gene Chr1:152684770-152815764 (-)
LP/J MGP_LPJ_G0016546
 protein coding gene Chr1:162906407-163046600 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016498
 protein coding gene Chr1:180756351-180906195 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017067
 protein coding gene Chr1:159837295-159981232 (-)
PWK/PhJ MGP_PWKPhJ_G0015760
 protein coding gene Chr1:153322424-153455553 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015547
 protein coding gene Chr1:158580614-158715080 (-)
WSB/EiJ MGP_WSBEiJ_G0016036
 protein coding gene Chr1:159939763-160077378 (-)



Homology
more
  • Human Ortholog
    RALGPS2, Ral GEF with PH domain and SH3 binding motif 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RALGPS2, Ral GEF with PH domain and SH3 binding motif 2
  • Synonyms
    dJ595C2.1
  • Links
    NCBI Gene ID: 55103
    neXtProt AC: NX_Q86X27
    UniProt: Q86X27

  • Chr Location
    1q25.2; chr1:178725165-178921842 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    918
  • Tissues
    39
  • cDNA Data
    193
  • Literature Summary
    6
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026594 Ensembl Gene Model | MGI Sequence Detail 135461 C57BL/6J ±  kb
transcript ENSMUST00000171292 Ensembl | MGI Sequence Detail 3346 Not Applicable  
polypeptide ENSMUSP00000130581 Ensembl | MGI Sequence Detail 590 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000013700 Ras-specific guanine nucleotide-releasing factor RalGPS2
    (term hierarchy)
  • InterPro Domains
    IPR011993 PH-like domain superfamily
    IPR001849 Pleckstrin homology domain
    IPR036964 Ras guanine-nucleotide exchange factor, catalytic domain superfamily
    IPR023578 Ras guanine nucleotide exchange factor domain superfamily
    IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
    IPR008937 Ras-like guanine nucleotide exchange factor
Molecular
Reagents
less
  • All nucleic 196
    cDNA 195
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
less
MGI:1916362, MGI:1917389, MGI:1921815, MGI:2138499, MGI:2138540
References
more
  • Summaries
    All 43
    Developmental Gene Expression 6
    Gene Ontology 4
    Phenotypes 10
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory