Ankrd23 MGI Mouse Gene Detail - MGI:1925571

Ankrd23 Gene Detail

Symbol

Ankrd23
Name

ankyrin repeat domain 23
Synonyms

1110058D09Rik, 2310041C05Rik, Darp, MARP3, MARP3

Feature Type

protein coding gene
IDs

MGI:1925571
NCBI Gene: 78321
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr1:36569269-36575964 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 15.31 cM
Mapping Data

2 experiments

SNPs within 2kb

308 from dbSNP Build 142
Strain Annotations

4

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1925571	protein coding gene	Chr1:36569269-36578380 (-)
129S1/SvImJ	no annotation
A/J	no annotation
AKR/J	no annotation
BALB/cJ	no annotation
C3H/HeJ	no annotation
C57BL/6NJ	no annotation
CAROLI/EiJ	MGP_CAROLIEiJ_G0014039	protein coding gene	Chr1:31181593-31198389 (-)
CAST/EiJ	no annotation
CBA/J	no annotation
DBA/2J	no annotation
FVB/NJ	no annotation
LP/J	no annotation
NOD/ShiLtJ	no annotation
NZO/HlLtJ	no annotation
PWK/PhJ	MGP_PWKPhJ_G0015061	protein coding gene	Chr1:33215374-33233757 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0014843	protein coding gene	Chr1:34593379-34612033 (-)
WSB/EiJ	no annotation

Human Ortholog

ANKRD23, ankyrin repeat domain 23

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ANKRD23, ankyrin repeat domain 23
Synonyms

DARP, MARP3
Links

HGNC:24470

NCBI Gene ID: 200539

neXtProt AC: NX_Q86SG2

UniProt: Q86SG2
Chr Location

2q11.2; chr2:96824526-96857934 (-) GRCh38

MGI Vertebrate Homology

Ankrd23 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: ANKRD23
Gene Tree

Ankrd23

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
3 phenotypes from multigenic genotypes
6 phenotype references

All Mutations and Alleles

2
Chemically induced (other)

1
Targeted

1
Genomic Mutations

1 involving Ankrd23
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

6 strains or lines available

Mice homozygous for a knock-out allele are viable, fertile, and exhibit no apparent cardiac phenotype.

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All GO Annotations

22
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

25
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

37
RefSeq

10
UniProt

1
CCDS

CCDS14882.1, CCDS78564.1

Ensembl

ENSMUSG00000067653 (Evidence)
NCBI Gene

78321

			Length	Strain/Species	Flank
genomic	ENSMUSG00000067653	Ensembl Gene Model \| MGI Sequence Detail	6696	C57BL/6J	± kb
transcript	ENSMUST00000054665	Ensembl \| MGI Sequence Detail	1964	Not Applicable
polypeptide	ENSMUSP00000061168	Ensembl \| MGI Sequence Detail	306	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000004045 ankyrin repeat domain-containing protein 23

(term hierarchy)

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All nucleic 25

cDNA 25

Microarray probesets 2

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MGI:1916019, MGI:2138368

Summaries

All 32

Developmental Gene Expression 1

Gene Ontology 7

Phenotypes 6
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:307828 Farrell E, et al., Transcriptome Analysis of Cardiac Hypertrophic Growth in MYBPC3-Null Mice Suggests Early Responders in Hypertrophic Remodeling. Front Physiol. 2018;9:1442

TSS for Ankrd23:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr11260	Chr1:36574800-36574845 (-)	1,141 bp
Tssr11259	Chr1:36573808-36573815 (-)	2,152 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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