Cdk19 MGI Mouse Gene Detail - MGI:1925584 - cyclin dependent kinase 19

Symbol

Cdk19
Name

cyclin dependent kinase 19
Synonyms

2700084L06Rik, Cdc2l6, mKIAA1028

Feature Type

protein coding gene
IDs

MGI:1925584
NCBI Gene: 78334
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr10:40225283-40359814 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 21.94 cM
Mapping Data

2 experiments

SNPs within 2kb

3241 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1925584	protein coding gene	Chr10:40215560-40359814 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017163	protein coding gene	Chr10:38907234-39069331 (+)
A/J	MGP_AJ_G0017140	protein coding gene	Chr10:37857366-37993099 (+)
AKR/J	MGP_AKRJ_G0017100	protein coding gene	Chr10:38401050-38538418 (+)
BALB/cJ	MGP_BALBcJ_G0017102	protein coding gene	Chr10:37928625-38064085 (+)
C3H/HeJ	MGP_C3HHeJ_G0016923	protein coding gene	Chr10:38721073-38860181 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017561	protein coding gene	Chr10:40139511-40283521 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015257	protein coding gene	Chr10:35821389-35960128 (+)
CAST/EiJ	MGP_CASTEiJ_G0016502	protein coding gene	Chr10:38909118-39062427 (+)
CBA/J	MGP_CBAJ_G0016897	protein coding gene	Chr10:41961604-42110944 (+)
DBA/2J	MGP_DBA2J_G0017002	protein coding gene	Chr10:37374849-37513597 (+)
FVB/NJ	MGP_FVBNJ_G0016997	protein coding gene	Chr10:36876285-37008751 (+)
LP/J	MGP_LPJ_G0017079	protein coding gene	Chr10:38898829-39043911 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017027	protein coding gene	Chr10:42809745-42950650 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017598	protein coding gene	Chr10:38381494-38521027 (+)
PWK/PhJ	MGP_PWKPhJ_G0016282	protein coding gene	Chr10:37249260-37388110 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016066	protein coding gene	Chr10:38218766-38355645 (+)
WSB/EiJ	MGP_WSBEiJ_G0016565	protein coding gene	Chr10:38690776-38842677 (+)

Human Ortholog

CDK19, cyclin dependent kinase 19

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CDK19, cyclin dependent kinase 19
Synonyms

bA346C16.3, CDC2L6, CDK11, DEE87, EIEE87
Links

HGNC:19338

NCBI Gene ID: 23097

neXtProt AC: NX_Q9BWU1

UniProt: Q9BWU1
Chr Location

6q21; chr6:110609978-110815958 (-) GRCh38

MGI Vertebrate Homology

Cdk19 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CDK19
Gene Tree

Cdk19

Diseases

1 with human CDK19 associations

				Human Disease	Mouse Models
				developmental and epileptic encephalopathy 87 IDs developmental and epileptic encephalopathy 87 DOID:0112221 OMIM:618916

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

7 phenotypes from 2 alleles in 2 genetic backgrounds
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

82
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

77
Radiation induced

1
Genomic Mutations

2 involving Cdk19
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

96 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit reduced hematopoietic stem cell proliferation.

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All GO Annotations

17
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

710
Tissues

4
cDNA Data

16
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA CDK19

Xenbase cdk19

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All Sequences

70
RefSeq

12
UniProt

8
CCDS

CCDS23795.1, CCDS48545.1

Ensembl

ENSMUSG00000038481 (Evidence)
NCBI Gene

78334

			Length	Strain/Species	Flank
genomic	78334	NCBI Gene Model \| MGI Sequence Detail	134532	C57BL/6J	± kb
transcript	NM_001168304	RefSeq \| MGI Sequence Detail	5828	C57BL/6
polypeptide	Q8BWD8	UniProt \| EBI \| MGI Sequence Detail	501	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000005199 cyclin-dependent kinase 19

(term hierarchy)
EC

2.7.11.22
InterPro Domains

IPR050108 Cyclin-dependent kinase

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

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All nucleic 17

cDNA 17

Microarray probesets 2

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MGI:2143682, MGI:2143829

Summaries

All 49

Developmental Gene Expression 2

Gene Ontology 9

Phenotypes 17
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cdk19:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr93015	Chr10:40225261-40225383 (+)	39 bp
Tssr93016	Chr10:40225470-40225514 (+)	209 bp
Tssr93017	Chr10:40262380-40262387 (+)	37,101 bp
Tssr3183	Chr10:40297887-40297932 (+)	72,627 bp
Tssr93018	Chr10:40302798-40302810 (+)	77,521 bp
Tssr93019	Chr10:40309885-40309896 (+)	84,608 bp
Tssr93020	Chr10:40320829-40320854 (+)	95,559 bp
Tssr93021	Chr10:40353676-40353723 (+)	128,417 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24