Fnbp1l MGI Mouse Gene Detail - MGI:1925642 - formin binding protein 1-like

Symbol

Fnbp1l
Name

formin binding protein 1-like
Synonyms

2610318I01Rik, TOCA1

Feature Type

protein coding gene
IDs

MGI:1925642
NCBI Gene: 214459
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr3:122332368-122413363 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 53.63 cM
Mapping Data

2 experiments

SNPs within 2kb

2044 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1925642	protein coding gene	Chr3:122332368-122413364 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0027840	protein coding gene	Chr3:124814948-124897627 (-)
A/J	MGP_AJ_G0027798	protein coding gene	Chr3:120633316-120714320 (-)
AKR/J	MGP_AKRJ_G0027764	protein coding gene	Chr3:123705545-123786745 (-)
BALB/cJ	MGP_BALBcJ_G0027810	protein coding gene	Chr3:120441891-120522550 (-)
C3H/HeJ	MGP_C3HHeJ_G0027541	protein coding gene	Chr3:124104781-124185898 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0028256	protein coding gene	Chr3:129334365-129416995 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025595	protein coding gene	Chr3:116059637-116143423 (-)
CAST/EiJ	MGP_CASTEiJ_G0026997	protein coding gene	Chr3:123497376-123583806 (-)
CBA/J	MGP_CBAJ_G0027516	protein coding gene	Chr3:133719325-133811726 (-)
DBA/2J	MGP_DBA2J_G0027657	protein coding gene	Chr3:119767674-119848193 (-)
FVB/NJ	MGP_FVBNJ_G0027625	protein coding gene	Chr3:117380134-117461075 (-)
LP/J	MGP_LPJ_G0027767	protein coding gene	Chr3:126329415-126411187 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027655	protein coding gene	Chr3:141266587-141351569 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028312	protein coding gene	Chr3:123266896-123350030 (-)
PWK/PhJ	MGP_PWKPhJ_G0026723	protein coding gene	Chr3:119477209-119560211 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0026546	protein coding gene	Chr3:121354211-121446873 (-)
WSB/EiJ	MGP_WSBEiJ_G0027077	protein coding gene	Chr3:123992960-124076368 (-)

Human Ortholog

FNBP1L, formin binding protein 1 like

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FNBP1L, formin binding protein 1 like
Synonyms

C1orf39, TOCA1
Links

HGNC:20851

NCBI Gene ID: 54874

neXtProt AC: NX_Q5T0N5

UniProt: Q5T0N5
Chr Location

1p22.1; chr1:93448118-93554661 (+) GRCh38

MGI Vertebrate Homology

Fnbp1l stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FNBP1L
Gene Tree

Fnbp1l

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References

1 with disease annotations

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

21
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

13
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Fnbp1l
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

30 strains or lines available

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All GO Annotations

20
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

833
Tissues

20
cDNA Data

10
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA FNBP1L

Xenbase fnbp1l

ZFIN fnbp1l

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All Sequences

49
RefSeq

4
UniProt

5
CCDS

CCDS17811.2, CCDS51062.1

Ensembl

ENSMUSG00000039735 (Evidence)
NCBI Gene

214459

			Length	Strain/Species	Flank
genomic	214459	NCBI Gene Model \| MGI Sequence Detail	80996	C57BL/6J	± kb
transcript	NM_001114665	RefSeq \| MGI Sequence Detail	5377	C57BL/6
polypeptide	Q8K012	UniProt \| EBI \| MGI Sequence Detail	605	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000007585 formin-binding protein 1-like

(term hierarchy)
InterPro Domains

IPR027267 AH/BAR domain superfamily

IPR031160 F-BAR domain

IPR001060 FCH domain

IPR035494 FNBP1L, F-BAR domain

IPR035493 FNBP1L, SH3 domain

IPR011072 HR1 rho-binding domain

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily

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All nucleic 10

cDNA 10

Microarray probesets 3

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MGI:2139999

Summaries

All 48

Developmental Gene Expression 5

Diseases 1

Gene Ontology 5

Phenotypes 18
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Fnbp1l:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr35463	Chr3:122413386-122413397 (-)	-29 bp
Tssr35462	Chr3:122413361-122413372 (-)	-4 bp
Tssr35461	Chr3:122413332-122413347 (-)	23 bp
Tssr35460	Chr3:122413312-122413329 (-)	42 bp
Tssr35459	Chr3:122413091-122413112 (-)	261 bp
Tssr35458	Chr3:122405870-122405875 (-)	7,490 bp
Tssr35457	Chr3:122383847-122383860 (-)	29,509 bp
Tssr35456	Chr3:122363359-122363398 (-)	49,984 bp
Tssr35455	Chr3:122362434-122362457 (-)	50,917 bp
Tssr35454	Chr3:122352748-122352765 (-)	60,606 bp
Tssr35453	Chr3:122345987-122345990 (-)	67,374 bp
Tssr35452	Chr3:122345183-122345190 (-)	68,176 bp
Tssr35451	Chr3:122333193-122333198 (-)	80,167 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24