Ddx52 MGI Mouse Gene Detail - MGI:1925644

Symbol

Ddx52
Name

DExD box helicase 52
Synonyms

2700029C06Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 52, ROK1

Feature Type

protein coding gene
IDs

MGI:1925644
NCBI Gene: 78394
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr11:83832888-83853914 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 51.24 cM, cytoband B5
Mapping Data

3 experiments

SNPs within 2kb

795 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1925644	protein coding gene	Chr11:83831659-83853914 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018863	protein coding gene	Chr11:85333256-85355217 (+)
A/J	MGP_AJ_G0018830	protein coding gene	Chr11:82092394-82114171 (+)
AKR/J	MGP_AKRJ_G0018800	protein coding gene	Chr11:84514335-84535332 (+)
BALB/cJ	MGP_BALBcJ_G0018803	protein coding gene	Chr11:82472977-82496499 (+)
C3H/HeJ	MGP_C3HHeJ_G0018617	protein coding gene	Chr11:84566206-84588101 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019255	protein coding gene	Chr11:87916740-87942943 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016888	protein coding gene	Chr11:79182983-79203736 (+)
CAST/EiJ	MGP_CASTEiJ_G0018172	protein coding gene	Chr11:85192679-85218698 (+)
CBA/J	MGP_CBAJ_G0018588	protein coding gene	Chr11:91697609-91720862 (+)
DBA/2J	MGP_DBA2J_G0018696	protein coding gene	Chr11:81669803-81691287 (+)
FVB/NJ	MGP_FVBNJ_G0018685	protein coding gene	Chr11:81140471-81161418 (+)
LP/J	MGP_LPJ_G0018766	protein coding gene	Chr11:85868272-85892014 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018712	protein coding gene	Chr11:91844975-91865935 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019295	protein coding gene	Chr11:84795544-84817655 (+)
PWK/PhJ	MGP_PWKPhJ_G0017941	protein coding gene	Chr11:82421057-82445384 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017733	protein coding gene	Chr11:84323173-84347946 (+)
WSB/EiJ	MGP_WSBEiJ_G0018223	protein coding gene	Chr11:84638262-84660248 (+)

Human Ortholog

DDX52, DExD-box helicase 52

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DDX52, DExD-box helicase 52
Synonyms

HUSSY19, ROK1
Links

HGNC:20038

NCBI Gene ID: 11056

neXtProt AC: NX_Q9Y2R4

UniProt: Q9Y2R4
Chr Location

17q12; chr17:37609739-37643446 (-) GRCh38

MGI Vertebrate Homology

Ddx52 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DDX52
Gene Tree

Ddx52

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

4
Targeted

3
Genomic Mutations

3 involving Ddx52
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

25 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

14
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

711
Tissues

4
cDNA Data

121
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ddx52

ZFIN ddx52

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All Sequences

45
RefSeq

3
UniProt

3
CCDS

CCDS25180.1

Ensembl

ENSMUSG00000020677 (Evidence)
NCBI Gene

78394

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020677	Ensembl Gene Model \| MGI Sequence Detail	21027	C57BL/6J	± kb
transcript	ENSMUST00000049257	Ensembl \| MGI Sequence Detail	3194	Not Applicable
polypeptide	ENSMUSP00000048802	Ensembl \| MGI Sequence Detail	598	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000029391 probable ATP-dependent RNA helicase DDX52

(term hierarchy)
EC

3.6.4.13
InterPro Domains

IPR044764 DDX52/Rok1, DEAD-box helicase domain

IPR050079 DEAD box RNA helicase

IPR011545 DEAD/DEAH box helicase domain

IPR001650 Helicase, C-terminal domain-like

IPR014001 Helicase superfamily 1/2, ATP-binding domain

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR014014 RNA helicase, DEAD-box type, Q motif

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All nucleic 123

cDNA 121

Primer pair 1

Other 1

Microarray probesets 4

Summaries

All 44

Developmental Gene Expression 1

Gene Ontology 7

Phenotypes 15
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ddx52:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr103779	Chr11:83832910-83832931 (+)	33 bp
Tssr103780	Chr11:83832937-83832958 (+)	60 bp
Tssr103781	Chr11:83832978-83833005 (+)	104 bp
Tssr103782	Chr11:83833041-83833044 (+)	155 bp
Tssr103783	Chr11:83846806-83846833 (+)	13,932 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24