Rnase6 MGI Mouse Gene Detail - MGI:1925666 - ribonuclease, RNase A family, 6

Symbol

Rnase6
Name

ribonuclease, RNase A family, 6
Synonyms

9530043P15Rik

Feature Type

protein coding gene
IDs

MGI:1925666
NCBI Gene: 78416
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr14:51361365-51369644 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 26.39 cM, cytoband C1
Mapping Data

4 experiments

SNPs within 2kb

279 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1925666	protein coding gene	Chr14:51361365-51369644 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021274	protein coding gene	Chr14:45101801-45103855 (+)
A/J	MGP_AJ_G0021229	protein coding gene	Chr14:43745033-43747087 (+)
AKR/J	MGP_AKRJ_G0021205	protein coding gene	Chr14:45393558-45395612 (+)
BALB/cJ	MGP_BALBcJ_G0021232	protein coding gene	Chr14:43875668-43877722 (+)
C3H/HeJ	MGP_C3HHeJ_G0021014	protein coding gene	Chr14:45213593-45215647 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021668	protein coding gene	Chr14:46948162-46950216 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019219	protein coding gene	Chr14:43076725-43078759 (+)
CAST/EiJ	MGP_CASTEiJ_G0020537	protein coding gene	Chr14:42293597-42295651 (+)
CBA/J	MGP_CBAJ_G0020981	protein coding gene	Chr14:48401834-48403888 (+)
DBA/2J	MGP_DBA2J_G0021105	protein coding gene	Chr14:43640093-43642147 (+)
FVB/NJ	MGP_FVBNJ_G0021084	protein coding gene	Chr14:43267449-43269502 (+)
LP/J	MGP_LPJ_G0021172	protein coding gene	Chr14:45388897-45390951 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021112	protein coding gene	Chr14:47917424-47919477 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021697	protein coding gene	Chr14:44876984-44879038 (+)
PWK/PhJ	MGP_PWKPhJ_G0020287	protein coding gene	Chr14:40555938-40557992 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020112	protein coding gene	Chr14:41051357-41053432 (+)
WSB/EiJ	MGP_WSBEiJ_G0020590	protein coding gene	Chr14:45080342-45082395 (+)

Human Ortholog

RNASE6, ribonuclease A family member 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RNASE6, ribonuclease A family member 6
Synonyms

RAD1, RNasek6, RNS6
Links

HGNC:10048

NCBI Gene ID: 6039

neXtProt AC: NX_Q93091

UniProt: Q93091
Chr Location

14q11.2; chr14:20781070-20782467 (+) GRCh38

MGI Vertebrate Homology

Rnase6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RNASE6
Gene Tree

Rnase6

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

2
Chemically induced (other)

1
Endonuclease-mediated

1
Genomic Mutations

1 involving Rnase6
Find Mice (IMSR)

8 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

25
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

800
Tissues

94
cDNA Data

12
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

47
RefSeq

5
UniProt

3
CCDS

CCDS27037.1

Ensembl

ENSMUSG00000021880 (Evidence)
NCBI Gene

78416

			Length	Strain/Species	Flank
genomic	78416	NCBI Gene Model \| MGI Sequence Detail	8280	C57BL/6J	± kb
transcript	NM_001360117	RefSeq \| MGI Sequence Detail	2452	C57BL/6
polypeptide	Q9D244	UniProt \| EBI \| MGI Sequence Detail	153	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000014049 ribonuclease K6

(term hierarchy)
EC

3.1.27.-
InterPro Domains

IPR001427 Pancreatic ribonuclease

IPR023411 Ribonuclease A, active site

IPR023412 Ribonuclease A-domain

IPR036816 Ribonuclease A-like domain superfamily
GlyGen

Q9D244 2 sites

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All nucleic 13

cDNA 12

Primer pair 1

Microarray probesets 2

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MGI:2145852

Summaries

All 32

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 5
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rnase6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr125412	Chr14:51366362-51366383 (+)	5,008 bp
Tssr125413	Chr14:51366387-51366404 (+)	5,031 bp
Tssr125414	Chr14:51366437-51366450 (+)	5,079 bp
Tssr125415	Chr14:51366464-51366475 (+)	5,105 bp
Tssr125416	Chr14:51366496-51366507 (+)	5,137 bp
Tssr125417	Chr14:51366512-51366529 (+)	5,156 bp
Tssr125418	Chr14:51366542-51366570 (+)	5,191 bp
Tssr125419	Chr14:51366575-51366596 (+)	5,221 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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