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Skap1 Gene Detail
Summary
  • Symbol
    Skap1
  • Name
    src family associated phosphoprotein 1
  • Synonyms
    1700091G21Rik, Skap-55
  • Feature Type
    protein coding gene
  • IDs
    MGI:1925723
    NCBI Gene: 78473
  • Alliance
    gene page
  • Transcription Start Sites
    32 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:96355419-96649956 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 59.93 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    7796 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1925723
 protein coding gene Chr11:96355396-96650448 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019010
 protein coding gene Chr11:98791585-99105332 (+)
A/J MGP_AJ_G0018978
 protein coding gene Chr11:94748338-95047443 (+)
AKR/J MGP_AKRJ_G0018948
 protein coding gene Chr11:97682287-97989527 (+)
BALB/cJ MGP_BALBcJ_G0018951
 protein coding gene Chr11:95251243-95547459 (+)
C3H/HeJ MGP_C3HHeJ_G0018765
 protein coding gene Chr11:97810754-98121895 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019403
 protein coding gene Chr11:101878072-102186900 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017033
 protein coding gene Chr11:92233930-92529584 (+)
CAST/EiJ MGP_CASTEiJ_G0018318
 protein coding gene Chr11:98645050-98956189 (+)
CBA/J MGP_CBAJ_G0018736
 protein coding gene Chr11:106043596-106366694 (+)
DBA/2J MGP_DBA2J_G0018844
 protein coding gene Chr11:94315410-94609549 (+)
FVB/NJ MGP_FVBNJ_G0018833
 protein coding gene Chr11:93794323-94088381 (+)
LP/J MGP_LPJ_G0018914
 protein coding gene Chr11:99318854-99626217 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018860
 protein coding gene Chr11:106025437-106332260 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019443
 protein coding gene Chr11:97988886-98292822 (+)
PWK/PhJ MGP_PWKPhJ_G0018090
 protein coding gene Chr11:95276478-95577403 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017879
 protein coding gene Chr11:97716547-98022031 (+)
WSB/EiJ MGP_WSBEiJ_G0018368
 protein coding gene Chr11:97883078-98200884 (+)



Homology
more
  • Human Ortholog
    SKAP1, src kinase associated phosphoprotein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SKAP1, src kinase associated phosphoprotein 1
  • Synonyms
    HEL-S-81p, SCAP1, SKAP55
  • Links
    NCBI Gene ID: 8631
    neXtProt AC: NX_Q86WV1
    UniProt: Q86WV1

  • Chr Location
    17q21.32; chr17:48133442-48445061 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit decreased T cell aggregation, adhesion and proliferation following stimulation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    13
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000057058 Ensembl Gene Model | MGI Sequence Detail 294538 C57BL/6J ±  kb
transcript ENSMUST00000103154 Ensembl | MGI Sequence Detail 1507 Not Applicable  
polypeptide ENSMUSP00000099443 Ensembl | MGI Sequence Detail 355 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    cDNA 13

    Microarray probesets 4
References
more
  • Summaries
    All 43
    Gene Ontology 7
    Phenotypes 15
  • Earliest
    J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
  • Latest
    J:319147 Lim D, et al., Non-cleavable talin rescues defect in the T-cell conjugation of T-cells deficient in the immune adaptor SKAP1. Immunol Lett. 2016 Apr;172:40-6
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory