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Itih5 Gene Detail
Summary
  • Symbol
    Itih5
  • Name
    inter-alpha-trypsin inhibitor, heavy chain 5
  • Synonyms
    4631408O11Rik, 5430408M01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1925751
    NCBI Gene: 209378
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:10158382-10261340 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 6.94 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    3621 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1925751
 protein coding gene Chr2:10158354-10261340 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025340
 protein coding gene Chr2:7507254-7606089 (+)
A/J MGP_AJ_G0025317
 protein coding gene Chr2:7173228-7273602 (+)
AKR/J MGP_AKRJ_G0025286
 protein coding gene Chr2:7410956-7510312 (+)
BALB/cJ MGP_BALBcJ_G0025313
 protein coding gene Chr2:7176142-7278042 (+)
C3H/HeJ MGP_C3HHeJ_G0025073
 protein coding gene Chr2:7358366-7461220 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025755
 protein coding gene Chr2:7699693-7808299 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023169
 protein coding gene Chr2:6685266-6786417 (+)
CAST/EiJ MGP_CASTEiJ_G0024536
 protein coding gene Chr2:7384374-7491545 (+)
CBA/J MGP_CBAJ_G0025052
 protein coding gene Chr2:8019920-8132570 (+)
DBA/2J MGP_DBA2J_G0025184
 protein coding gene Chr2:7104477-7204689 (+)
FVB/NJ MGP_FVBNJ_G0025146
 protein coding gene Chr2:7048472-7145136 (+)
LP/J MGP_LPJ_G0025270
 protein coding gene Chr2:7385461-7488313 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025178
 protein coding gene Chr2:7988446-8087339 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025813
 protein coding gene Chr2:7360244-7464030 (+)
PWK/PhJ MGP_PWKPhJ_G0024287
 protein coding gene Chr2:7090816-7192999 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024087
 protein coding gene Chr2:7348911-7447183 (+)
WSB/EiJ MGP_WSBEiJ_G0024606
 protein coding gene Chr2:7450838-7548267 (+)



Homology
more
  • Human Ortholog
    ITIH5, inter-alpha-trypsin inhibitor heavy chain 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ITIH5, inter-alpha-trypsin inhibitor heavy chain 5
  • Synonyms
    ITI-HC5, PP14776
  • Links
    NCBI Gene ID: 80760
    neXtProt AC: NX_Q86UX2
    UniProt: Q86UX2

  • Chr Location
    10p14; chr10:7559270-7666998 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1009
  • Tissues
    95
  • cDNA Data
    62
  • Literature Summary
    11
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025780 Ensembl Gene Model | MGI Sequence Detail 102959 C57BL/6J ±  kb
transcript ENSMUST00000026886 Ensembl | MGI Sequence Detail 7900 Not Applicable  
polypeptide ENSMUSP00000026886 Ensembl | MGI Sequence Detail 952 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000009150 inter-alpha-trypsin inhibitor heavy chain H5
    (term hierarchy)
  • InterPro Domains
    IPR050934 Inter-alpha-trypsin inhibitor heavy chain
    IPR010600 Inter-alpha-trypsin inhibitor heavy chain, C-terminal
    IPR013694 VIT domain
    IPR036465 von Willebrand factor A-like domain superfamily
    IPR002035 von Willebrand factor, type A
  • GlyGen
    Q8BJD1 8 sites, 6 N-linked glycans (4 sites)
Molecular
Reagents
less
  • All nucleic 68
    cDNA 64
    Primer pair 3
    Other 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:1913943
References
more
  • Summaries
    All 41
    Developmental Gene Expression 11
    Gene Ontology 4
    Phenotypes 7
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:359016 Sessler TM, et al., Genetic deletion of ITIH5 leads to increased development of adipose tissue in mice. Biol Res. 2024 Aug 29;57(1):58
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory