Micu3 MGI Mouse Gene Detail - MGI:1925756 - mitochondrial calcium uptake family, member 3

Symbol

Micu3
Name

mitochondrial calcium uptake family, member 3
Synonyms

2900075B16Rik, Efha2

Feature Type

protein coding gene
IDs

MGI:1925756
NCBI Gene: 78506
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr8:40760499-40839349 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 23.89 cM, cytoband B1.2
Mapping Data

2 experiments

SNPs within 2kb

1934 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1925756	protein coding gene	Chr8:40760394-40841824 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033551	protein coding gene	Chr8:39109151-39183599 (+)
A/J	MGP_AJ_G0033531	protein coding gene	Chr8:37620969-37693959 (+)
AKR/J	MGP_AKRJ_G0033455	protein coding gene	Chr8:38731285-38806553 (+)
BALB/cJ	MGP_BALBcJ_G0033527	protein coding gene	Chr8:37712731-37785225 (+)
C3H/HeJ	MGP_C3HHeJ_G0033239	protein coding gene	Chr8:39125359-39203594 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034043	protein coding gene	Chr8:40604639-40681243 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030992	protein coding gene	Chr8:34245673-34320602 (+)
CAST/EiJ	MGP_CASTEiJ_G0032567	protein coding gene	Chr8:38643936-38726606 (+)
CBA/J	MGP_CBAJ_G0033217	protein coding gene	Chr8:42287302-42367279 (+)
DBA/2J	MGP_DBA2J_G0033370	protein coding gene	Chr8:37471905-37545292 (+)
FVB/NJ	MGP_FVBNJ_G0033315	protein coding gene	Chr8:37045767-37120574 (+)
LP/J	MGP_LPJ_G0033460	protein coding gene	Chr8:39135905-39208610 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033357	protein coding gene	Chr8:42071093-42152806 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034062	protein coding gene	Chr8:38930355-39005728 (+)
PWK/PhJ	MGP_PWKPhJ_G0032276	protein coding gene	Chr8:37010068-37086216 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032108	protein coding gene	Chr8:38124843-38203352 (+)
WSB/EiJ	MGP_WSBEiJ_G0032682	protein coding gene	Chr8:39117352-39201439 (+)

Human Ortholog

MICU3, mitochondrial calcium uptake family member 3

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MICU3, mitochondrial calcium uptake family member 3
Synonyms

EFHA2, hMICU3
Links

HGNC:27820

NCBI Gene ID: 286097

neXtProt AC: NX_Q86XE3

UniProt: Q86XE3
Chr Location

8p22; chr8:17027238-17138640 (+) GRCh38

MGI Vertebrate Homology

Micu3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MICU3
Gene Tree

Micu3

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

2
Gene trapped

3
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

16
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

6
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

45
RefSeq

6
UniProt

4
CCDS

CCDS52545.1

Ensembl

ENSMUSG00000039478 (Evidence)
NCBI Gene

78506

			Length	Strain/Species	Flank
genomic	ENSMUSG00000039478	Ensembl Gene Model \| MGI Sequence Detail	78851	C57BL/6J	± kb
transcript	ENSMUST00000068999	Ensembl \| MGI Sequence Detail	2219	Not Applicable
polypeptide	ENSMUSP00000070241	Ensembl \| MGI Sequence Detail	523	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000032417 calcium uptake protein 3, mitochondrial

(term hierarchy)
InterPro Domains

IPR039800 Calcium uptake protein 1/2/3

IPR018247 EF-Hand 1, calcium-binding site

IPR002048 EF-hand domain

IPR011992 EF-hand domain pair
GlyGen

Q9CTY5 1 site, 1 O-linked glycan (1 site)

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All nucleic 6

cDNA 6

Microarray probesets 4

Summaries

All 36

Developmental Gene Expression 1

Gene Ontology 8

Phenotypes 8
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:359014 Roman B, et al., MICU3 Regulates Mitochondrial Calcium and Cardiac Hypertrophy. Circ Res. 2024 Jun 21;135(1):26-40

TSS for Micu3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr76950	Chr8:40761042-40761091 (+)	568 bp
Tssr76951	Chr8:40838397-40838401 (+)	77,900 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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