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Jade1 Gene Detail
Summary
  • Symbol
    Jade1
  • Name
    jade family PHD finger 1
  • Synonyms
    D530048A03Rik, mKIAA1807, Phf17
  • Feature Type
    protein coding gene
  • IDs
    MGI:1925835
    NCBI Gene: 269424
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:41510169-41571299 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 19.88 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1359 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1925835
 protein coding gene Chr3:41510166-41571299 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027186
 protein coding gene Chr3:39565343-39631619 (+)
A/J MGP_AJ_G0027146
 protein coding gene Chr3:38596022-38657962 (+)
AKR/J MGP_AKRJ_G0027115
 protein coding gene Chr3:39326346-39388764 (+)
BALB/cJ MGP_BALBcJ_G0027158
 protein coding gene Chr3:38369422-38434603 (+)
C3H/HeJ MGP_C3HHeJ_G0026901
 protein coding gene Chr3:39451421-39517104 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027604
 protein coding gene Chr3:41201879-41266123 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024964
 protein coding gene Chr3:36101953-36162462 (+)
CAST/EiJ MGP_CASTEiJ_G0026354
 protein coding gene Chr3:39334430-39400720 (+)
CBA/J MGP_CBAJ_G0026878
 protein coding gene Chr3:42359660-42426031 (+)
DBA/2J MGP_DBA2J_G0027012
 protein coding gene Chr3:38063418-38124913 (+)
FVB/NJ MGP_FVBNJ_G0026980
 protein coding gene Chr3:37437009-37498280 (+)
LP/J MGP_LPJ_G0027124
 protein coding gene Chr3:40306137-40375127 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026998
 protein coding gene Chr3:44813088-44876087 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027663
 protein coding gene Chr3:39203909-39264895 (+)
PWK/PhJ MGP_PWKPhJ_G0026086
 protein coding gene Chr3:37744064-37811400 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025899
 protein coding gene Chr3:38860068-38926619 (+)
WSB/EiJ MGP_WSBEiJ_G0026428
 protein coding gene Chr3:39214587-39280912 (+)



Homology
more
  • Human Ortholog
    JADE1, jade family PHD finger 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    JADE1, jade family PHD finger 1
  • Synonyms
    PHF17
  • Links
    NCBI Gene ID: 79960
    neXtProt AC: NX_Q6IE81
    UniProt: Q6IE81

  • Chr Location
    4q28.2; chr4:128809700-128875224 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Though mice homozygous for mutations of this locus show no overt phenotype at birth, fewer survive to weaning than expected by Mendelian ratios.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    807
  • Tissues
    66
  • cDNA Data
    20
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 269424 NCBI Gene Model | MGI Sequence Detail 61131 C57BL/6J ±  kb
    transcript NM_172303 RefSeq | MGI Sequence Detail 5584 C57BL/6  
    polypeptide Q6ZPI0 UniProt | EBI | MGI Sequence Detail 834 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 20
      Primer pair 5

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2139907
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 10
      Phenotypes 22
    • Earliest
      J:64276 Lyon MF, et al., Dose-response curves for radiation-induced gene mutations in mouse oocytes and their interpretation. Mutat Res. 1979 Nov;63(1):161-73
    • Latest
      J:344221 Wang J, et al., JADE1 is dispensable for the brain development in mice. Biochem Biophys Res Commun. 2023 Dec 27;695:149421
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory