Acap2 MGI Mouse Gene Detail - MGI:1925868 - ArfGAP with coiled-coil, ankyrin repeat and PH domains 2

Symbol

Acap2
Name

ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
Synonyms

9530039J15Rik, Centb2

Feature Type

protein coding gene
IDs

MGI:1925868
NCBI Gene: 78618
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr16:30911230-31020063 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 21.34 cM, cytoband B2
Mapping Data

2 experiments

SNPs within 2kb

2833 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1925868	protein coding gene	Chr16:30911230-31020105 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022717	protein coding gene	Chr16:29035217-29150562 (-)
A/J	MGP_AJ_G0022680	protein coding gene	Chr16:27693033-27803643 (-)
AKR/J	MGP_AKRJ_G0022654	protein coding gene	Chr16:28742477-28863118 (-)
BALB/cJ	MGP_BALBcJ_G0022684	protein coding gene	Chr16:27873682-27984507 (-)
C3H/HeJ	MGP_C3HHeJ_G0022449	protein coding gene	Chr16:28844469-28956461 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0023133	protein coding gene	Chr16:29673774-29796552 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020651	protein coding gene	Chr16:28122893-28231592 (-)
CAST/EiJ	MGP_CASTEiJ_G0021977	protein coding gene	Chr16:28963558-29074390 (-)
CBA/J	MGP_CBAJ_G0022419	protein coding gene	Chr16:30917629-31038660 (-)
DBA/2J	MGP_DBA2J_G0022552	protein coding gene	Chr16:27571400-27679485 (-)
FVB/NJ	MGP_FVBNJ_G0022527	protein coding gene	Chr16:27548122-27657064 (-)
LP/J	MGP_LPJ_G0022619	protein coding gene	Chr16:28842651-28959593 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022546	protein coding gene	Chr16:30407044-30517935 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023145	protein coding gene	Chr16:28695240-28809309 (-)
PWK/PhJ	MGP_PWKPhJ_G0021716	protein coding gene	Chr16:27886704-27993210 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021547	protein coding gene	Chr16:28471815-28583758 (-)
WSB/EiJ	MGP_WSBEiJ_G0022021	protein coding gene	Chr16:28650351-28756911 (-)

Human Ortholog

ACAP2, ArfGAP with coiled-coil, ankyrin repeat and PH domains 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ACAP2, ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
Synonyms

CENTB2, CNT-B2
Links

HGNC:16469

NCBI Gene ID: 23527

neXtProt AC: NX_Q15057

UniProt: Q15057
Chr Location

3q29; chr3:195274745-195443044 (-) GRCh38

MGI Vertebrate Homology

Acap2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ACAP2
Gene Tree

Acap2

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

23
Endonuclease-mediated

1
Gene trapped

20
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

56 strains or lines available

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All GO Annotations

14
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

716
Tissues

10
cDNA Data

92
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase acap2

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All Sequences

79
RefSeq

24
UniProt

6
CCDS

CCDS49823.1

Ensembl

ENSMUSG00000049076 (Evidence)
NCBI Gene

78618

			Length	Strain/Species	Flank
genomic	ENSMUSG00000049076	Ensembl Gene Model \| MGI Sequence Detail	108834	C57BL/6J	± kb
transcript	ENSMUST00000229010	Ensembl \| MGI Sequence Detail	2810	Not Applicable
polypeptide	ENSMUSP00000156077	Ensembl \| MGI Sequence Detail	805	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000003608 Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2

(term hierarchy)
InterPro Domains

IPR027267 AH/BAR domain superfamily

IPR002110 Ankyrin repeat

IPR036770 Ankyrin repeat-containing domain superfamily

IPR045258 ArfGAP ACAP1/2/3-like

IPR038508 ArfGAP domain superfamily

IPR037278 ARFGAP/RecO-like zinc finger

IPR001164 Arf GTPase activating protein

IPR004148 BAR domain

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain
GlyGen

Q6ZQK5 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)

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All nucleic 93

cDNA 92

Primer pair 1

Microarray probesets 3

Summaries

All 35

Developmental Gene Expression 1

Gene Ontology 7

Phenotypes 7
Earliest

J:65271 Dowler S, et al., Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities. Biochem J. 2000 Oct 1;351(Pt 1):19-31
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Acap2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr140736	Chr16:31019968-31020061 (-)	48 bp
Tssr140735	Chr16:31010768-31010805 (-)	9,276 bp
Tssr140734	Chr16:30997858-30997862 (-)	22,203 bp
Tssr140733	Chr16:30990384-30990387 (-)	29,677 bp
Tssr140732	Chr16:30986809-30986813 (-)	33,252 bp
Tssr140731	Chr16:30970737-30970741 (-)	49,324 bp
Tssr140730	Chr16:30962623-30962626 (-)	57,438 bp
Tssr140729	Chr16:30960933-30960947 (-)	59,123 bp
Tssr140728	Chr16:30960896-30960922 (-)	59,154 bp
Tssr140727	Chr16:30959356-30959359 (-)	60,705 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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