C1qtnf7 MGI Mouse Gene Detail - MGI:1925911 - C1q and tumor necrosis factor related protein 7

Symbol

C1qtnf7
Name

C1q and tumor necrosis factor related protein 7
Synonyms

5530401N20Rik, 8430425G24Rik, CTRP7

Feature Type

protein coding gene
IDs

MGI:1925911
NCBI Gene: 109323
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr5:43672881-43776145 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 23.78 cM
Mapping Data

1 experiment

SNPs within 2kb

3434 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1925911	protein coding gene	Chr5:43672792-43776805 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029522	protein coding gene	Chr5:42143413-42245932 (+)
A/J	MGP_AJ_G0029488	protein coding gene	Chr5:40685565-40793572 (+)
AKR/J	MGP_AKRJ_G0029438	protein coding gene	Chr5:42133512-42238410 (+)
BALB/cJ	MGP_BALBcJ_G0029499	protein coding gene	Chr5:41159202-41265276 (+)
C3H/HeJ	MGP_C3HHeJ_G0029222	protein coding gene	Chr5:42103950-42207670 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029953	protein coding gene	Chr5:44179588-44286097 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027192	protein coding gene	Chr5:37936631-38037372 (+)
CAST/EiJ	MGP_CASTEiJ_G0028630	protein coding gene	Chr5:41216188-41327718 (+)
CBA/J	MGP_CBAJ_G0029191	protein coding gene	Chr5:45330190-45448482 (+)
DBA/2J	MGP_DBA2J_G0029336	protein coding gene	Chr5:40780203-40882911 (+)
FVB/NJ	MGP_FVBNJ_G0029297	protein coding gene	Chr5:40205504-40308205 (+)
LP/J	MGP_LPJ_G0029422	protein coding gene	Chr5:42582633-42696055 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029325	protein coding gene	Chr5:46148791-46254385 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029986	protein coding gene	Chr5:41620112-41727790 (+)
PWK/PhJ	MGP_PWKPhJ_G0028354	protein coding gene	Chr5:39901513-40007080 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028188	protein coding gene	Chr5:41056092-41161039 (+)
WSB/EiJ	MGP_WSBEiJ_G0028711	protein coding gene	Chr5:41685004-41799109 (+)

Human Ortholog

C1QTNF7, C1q and TNF related 7

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

C1QTNF7, C1q and TNF related 7
Synonyms

CTRP7, ZACRP7
Links

HGNC:14342

NCBI Gene ID: 114905

neXtProt AC: NX_Q9BXJ2

UniProt: Q9BXJ2
Chr Location

4p15.32; chr4:15339786-15446167 (+) GRCh38

MGI Vertebrate Homology

C1qtnf7 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: C1QTNF7
Gene Tree

C1qtnf7

less

References

1 with disease annotations

less

Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
24 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (ENU)

1
Chemically induced (other)

2
Endonuclease-mediated

1
Radiation induced

2
Spontaneous

1
Targeted

2
Genomic Mutations

6 involving C1qtnf7
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit decreased weight, liver fibrosis, male-specific glucose serum levels and adipose inflammation with male-specific improved glucose tolerance when fed a high-fat diet.

less

All GO Annotations

4
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

811
Tissues

49
cDNA Data

7
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

less

All Sequences

42
RefSeq

6
UniProt

4
CCDS

CCDS19262.1, CCDS51488.1

Ensembl

ENSMUSG00000061535 (Evidence)
NCBI Gene

109323

			Length	Strain/Species	Flank
genomic	ENSMUSG00000061535	Ensembl Gene Model \| MGI Sequence Detail	103265	C57BL/6J	± kb
transcript	ENSMUST00000076939	Ensembl \| MGI Sequence Detail	3879	Not Applicable
polypeptide	ENSMUSP00000076206	Ensembl \| MGI Sequence Detail	296	Not Applicable

less

UniProt

4 Sequences
Protein Ontology

PR:000004889 complement C1q tumor necrosis factor-related protein 7

(term hierarchy)
InterPro Domains

IPR001073 C1q domain

IPR050392 Collagen/C1q domain-containing

IPR008160 Collagen triple helix repeat

IPR008983 Tumour necrosis factor-like domain superfamily

less

All nucleic 9

cDNA 8

Primer pair 1

Microarray probesets 3

less

MGI:1918691

Summaries

All 46

Developmental Gene Expression 3

Diseases 1

Gene Ontology 3

Phenotypes 24
Earliest

J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for C1qtnf7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr46087	Chr5:43672819-43672828 (+)	-57 bp
Tssr46088	Chr5:43672856-43672877 (+)	-14 bp
Tssr46089	Chr5:43673094-43673137 (+)	235 bp
Tssr46090	Chr5:43673149-43673161 (+)	274 bp
Tssr46091	Chr5:43673264-43673273 (+)	388 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24